Month: August 2017

The Role of Altered Bacterial Gut Microbiota and Gut Mycobiota on Gastrointestinal Symptoms Associated with Autism Spectrum Disorder (ASD).

August 2, 2017 John Hiett
John Hiett Introduction. Autism spectrum disorder (ASD) is a developmental disability that includes social and communication impairments, restricted interests, and repetitive behaviors. Although the etiology of ASD in not completely known, a very strong genetic component has been identified.5 Compared to healthy controls, children and adults with ASD typically suffer…
Featured Abstracts Microbiology Neuroscience

Disruption of the host deubiquitinating enzyme, USP14, as a novel therapeutic strategy to combat Listeria monocytogenes infection

August 2, 2017 Kevin M. Claunch
Kevin M. Claunch, M.S.  Introduction. The Unfolded Protein Response (UPR) is a critical homeostatic pathway in mammalian cells that is triggered by ER dysfunction and subsequent accumulation of misfolded and damaged proteins1,7. Activation of the UPR is achieved through three transmembrane proteins, one of which is IRE-1, which catalyzes the…
Featured Abstracts Microbiology

From quinones to mitochondria: exploring the ‘complex’ progression of oxidative stress in Parkinson’s Disease

August 2, 2017 Imran Zafar
Imran Zafar Introduction. Parkinson’s Disease (PD) is a long-term neurodegenerative disease and progressive movement disorder of the CNS due largely to neuronal death of the substantia nigra region of the midbrain and subsequent loss of dopamine production. Although the cause is largely unknown, it is suggested that oxidative stress, free…
Featured Abstracts Neuroscience

Mechanism of Nervous System Damage Caused by ZIKA Virus: The Role of AXL Receptor in Viral Entry

August 2, 2017 Serin Thomas
Serin Thomas Introduction: Zika virus (ZIKV) is a RNA flavivirus that has gained global attention since 2015 after a major outbreak in Brazil.1-3 Although ZIKV is primarily spread by bites of Aedes mosquitos, it can also be spread through unprotected sexual intercourse as well as through placental transmission from an infected mother.1-4…
Featured Abstracts Microbiology

The Role of Extracellular Vesicles in the Pathogenesis of Preeclampsia

August 2, 2017 Jennifer Rogers
Jennifer Rogers Introduction. Preeclampsia (PE), a hypercoagulable pregnancy disorder that involves multiple organs, is a leading cause of maternal and fetal mortality.1,2 PE is characterized by hypertension presenting after 20 weeks gestation, along with other symptoms, including proteinuria, thrombocytopenia, edema, and cerebral or visual changes.1,2 If PE remains untreated, it…
Featured Abstracts Reproduction

Mobilizing Regulatory T Cells Against Type I Diabetes

August 2, 2017 Robert Leonard
Robert Leonard Introduction: Type I diabetes (T1D) is a chronic autoimmune disease where self-reactive T cells damage insulin-producing pancreatic beta cells resulting in hyperglycemia1. The etiology is unclear but evidence suggests it arises from an environmental trigger with genetic predisposition1. Treatment of T1D, although advancing, still consists of insulin replacement…
Endocrinology Featured Abstracts Immunology