Month: September 2017

Manipulation of the Microbiome-Gut-Brain Axis in Infants May Influence the Development of Autism and Other Psychological Disorders

September 21, 2017 Britton Eastburn
Britton Eastburn Introduction Neuroactive compounds produced by the normal microbiota colonizing the human gut have been found to directly influence a range of neurological and behavioral parameters such as mood, cognition, sleep, and appetite1, 2. Indeed, therapeutic manipulation of the microbiome using probiotics, for example, has proven successful in relieving…
Immunology Neuroscience

Induction of regulatory T-cells to treat Type 1 Diabetes Mellitus

September 21, 2017 Gina Do
Gina Do Introduction: Type 1 diabetes mellitus (T1D) is an autoimmune disease where the host’s immune system attacks pancreatic β-cells, causing insufficient insulin production and, therefore, hyperglycemia1. Symptomatic progression of T1D often occurs during childhood and adolescence, with new diagnoses estimated at almost 90,000 children annually worldwide1. There is no…
Endocrinology Immunology

The Role of the Intestinal Microbiome in the Pathogenesis of Autistic Spectrum Disorder

September 21, 2017 achael Helpenstell Counts
Rachael Helpenstell Counts  Introduction.  Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by limited social communication skills and stereotypical behavioral patterns.1,2 Many ASD patients also have gastrointestinal (GI) symptoms.2 Because of the heterogeneity of ASD, it is difficult to identify a single cause. However, environment, especially the intestinal microbiome,…
Microbiology Neuroscience

Reduction of Tau Hyperphosphorylation through Selenomethionine as a Therapeutic Agent for Alzheimer’s Disease

September 21, 2017 Su Min Cho
Su Min Cho Introduction: Alzheimer’s disease is currently the leading cause of dementia and continues to rise in prevalence as the population ages[1]. Tau proteins are believed to play a major role in various neurodegenerative diseases including Alzheimer’s disease[1,2]. Tau is normally a soluble, microtubule-binding protein that stabilizes the microtubules…
Neuroscience

Exploring the role of inflammation in colorectal carcinogenesis, and the use of Fc receptor-targeted therapies to target inflammation-mediated cancer development

September 21, 2017 Rihin Chavda
Rihin Chavda Introduction: It is well established that inflammation is strongly associated with colorectal carcinogenesis. Pathology of acute and chronic inflammation contribute to genomic damage and promotion of cancer (7). Fc therapy has been exploited in many forms of cancers to deliver immunoconjugates that deliver the toxin or radioisotope readily.…
Cancer Immunology

Using CRISPR Cas9 Gene Editing to Generate CAR (Chimeric Antigen Receptor) T-Cells for Immunotherapeutic Treatment of Leukemia

September 21, 2017 Jeffrey Cao
Jeffrey Cao Background: Leukemia is a cancer in which blood-forming tissues like bone marrow generate high numbers of immature or abnormal leukocytes, suppressing the production of normal blood cells. Like most cancers, malignant cells in leukemia exhibit immune evasion and resist checkpoint inhibition, which pose challenges to therapy. To overcome…
Cancer Immunology