Author: Bradley Conn

Regulating Hepatic Lipids via FXR Agonism and the Treatment of Non-Alcoholic Fatty Liver Disease

June 20, 2023 Bradley Conn
Bradley Conn Background: Non-alcoholic fatty liver disease (NAFLD) is a progressive disease in which fat abnormally accumulates (steatosis) in the liver.1 NAFLD can progress to fibrosis, cirrhosis, hepatocellular carcinoma and potentially death.2 The prevalence of NAFLD in the general population is 25%, in individuals with Type 2 Diabetes it is…
Featured Abstracts Hematology

Reducing FRαAb Related Folate Loss with Folinic Acid Supplementation to Improve Behavioral Symptoms in Autism Spectrum Disorder

June 20, 2023 Cody Schilhab
Cody Schilhab  Background: Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders characterized by variable impaired social communication and restricted or repetitive sensory-motor behaviors1. Prevalence of ASD is high and has increased from 1/150 in 2000 to 1/36 in 2016, with a 4:1 male to female ratio2. Recent studies…
Neuroscience Psychiatry

Mesenchymal Stem Cell Exosomes Provide Function-Saving Immunomodulatory Effects in Myocardial Infarction Through Macrophage Polarization

June 20, 2023 Christopher Story
Christopher Story Background: A Myocardial Infarction (MI) is a life-threatening cardiac event that afflicts over 800,000 individuals every year in the United States alone resulting in either fatality or a significant reduction in heart function.1 MI’s occur when one or more coronary arteries become occluded leading to a lack of…
Cardiology Immunology

Acetylation and Activation of AR K609 and ACK1 Promote Resistance to Androgen Receptor Antagonists in Castration-Resistant Prostate Cancer

June 20, 2023 Bryan Kim
Bryan Kim  Background: Prostate cancer is the leading cancer diagnosis in men and one of the leading causes of cancer-related death in the United States.1 Castration-resistant prostate cancer (CRPC) is the radiographic progression and/or rising prostate-specific antigen (PSA) following androgen deprivation therapy (ADT).2 CRPC patients exhibit resistance to second-generation androgen…
Cancer Endocrinology

The Role of Promising Therapeutic Target, Plasminogen-binding Protein (PbsP), in the Pathogenicity of S. agalactiae and Development of Neonatal GBS Meningitis

June 8, 2023 Megan Branum
Megan Branum Background: Neonatal invasive GBS disease is the leading cause of infection-related neonatal morbidity and mortality globally, caused by the bacterium Streptococcus agalactiae, colloquially known as Group-B Streptococcus (GBS).1-4  After transmission from asymptomatically colonized genitourinary tracts of pregnant women, GBS utilizes virulence factors for pathogenic invasion of neonates.1-4 Current…
Featured Abstracts Microbiology

The Emerging Role of Chimeric Antigen Receptor Therapies in the Treatment of Autoimmune Disorders

June 8, 2023 Scarlett Bloodworth
Scarlett Bloodworth   Background: Newly engineered chimeric antigen receptor T lymphocyte therapies have been successfully used in certain cancers, including leukemias and non-Hodgkin lymphoma.1 These CAR-T therapies are used to eradicate over-proliferating cells by programming cytotoxic T lymphocytes to induce apoptosis upon binding the B lymphocyte specific cell marker CD19.2…
Cancer Featured Abstracts Immunology

CD40 Agonists Reprogram Tumor Associated Macrophages to Reduce Immunosuppression in Pancreatic Ductal Adenocarcinoma

June 8, 2023 Baylee J. O’Brien
Baylee J. O’Brien  Background: Pancreatic ductal adenocarcinoma (PDAC) is cancer of the ductal cells of the pancreas and is projected to become the second leading cause of cancer related deaths by 20301. The low survival rate is largely due to the fibrotic stroma of the PDAC tumor microenvironment with infiltration…
Cancer Featured Abstracts Immunology