The Role of ADAMTS13 in Dynamic Interaction with Von Willebrand Factor As Potential Anti-thrombotic Therapy for Acute Ischemic Stroke

Mien Vu Introduction: In the United States, stroke is the leading cause of disability and the fifth leading cause of death1,2. It is estimated 60-80% of stroke cases are ischemic1,2. Current treatment guidelines as recommended by American Heart Association include intravenous thrombolysis with tissue Plasminogen Activator (tPA) and mechanical removal…
Cardiology

Neuroprotective Effects of Galantamine on Nerve Agent Toxicity and Damage

Andres Urrutia Introduction: Organophosphate (OP) based nerve agent weapons are a large concern in today’s geopolitical climate due to their lethality. Death from exposure is typically cardiac/respiratory arrest secondary to cholinergic over-stimulation which leads to parasympathomimetic symptoms1,2. However, for physicians, there is a significantly higher likelihood of running into OP…
Neuroscience

The Impact of Sex-Based Differences in Glioblastoma Multiforme (GBM): Tumor Suppressor Proteins TP53, TP16, and TP21

Caren Stuebe  Introduction. Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor.1 GBM is characterized as a grade IV glioma diagnosed with imaging and biopsy.2,3 With standard of care treatment of  maximal surgical resection, radiation, and temozolomide chemotherapy, median survival is 12-14.6 months.1,2,3,4 Of note is the…
Cancer Featured Abstracts

The Functional Role of Neuronal Transporter EAAT3 in the Pathogenesis of Obsessive-Compulsive Disorder

Neel Shah  Introduction. Obsessive-Compulsive Disorder (OCD) is characterized by having recurrent unwanted thoughts and fears (obsessions) that lead to organized and ritualistic behaviors (compulsions)1-5. Even with a prevalence of 2%-3% in the worldwide population, up to 40% of patients report no response to first-line treatments of selective serotonin reuptake inhibitors…
Neuroscience

The Differing Effects of Buprenorphine Compared to Methadone on Neonatal Abstinence Syndrome as a Treatment in Pregnant Women Concurrently Abusing Opioids

Tiffany Rudzitis  Introduction. Opioid abuse in pregnant women has become a prevalent public health concern as reported cases have increased 333% from 1.5 per 1000 deliveries in 1999 to 6.5 per 1000 deliveries in 2014.2 One of many consequences of opioid abuse during pregnancy is Neonatal Abstinence Syndrome (NAS). NAS…
Development