Relating the Efficacy of Rigid Braces in Treating Adolescent Idiopathic Scoliosis to Patient Quality of Life in Brace

Gabrielle Rogie Introduction. Adolescent idiopathic scoliosis (AIS) is defined as an abnormal lateral curvature of the spine, greater than 10* Cobb angle, without any underlying cause. Scoliosis presents as an abnormal shape of the back and waistline, uneven shoulders, and rib protrusion when instructed to bend forward. Further diagnosis is…
Engineering Medicine Orthopedics

CSF Aβ42/Aβ40 is a Potential Predictor of AD Pathology in Comparison to Other Available Biomarkers

Claire Sweeney and Ian Murray, PhD Introduction. Alzheimer’s disease (AD) is a neurodegenerative disease in which tau and amyloid proteins misfold to form pathological neurofibrillary tangles and amyloid plaques.6 There are an estimated 50 million AD patients worldwide and this number is expected to triple by 2050 as the increasing…
Engineering Medicine Neuroscience

Plasma Osteopontin As A Biomarker to Diagnose and Assess Pediatric Traumatic Brain Injury

Sindhura Sridhar Introduction. Pediatric traumatic brain injury (pTBI) is the leading cause of death and disability in children, impacting 475,000 children in the US between the ages 0-14 annually1. Children who experience at least one traumatic brain injury (TBI) are at risk for developing long-term physical, cognitive, and psychological consequences2.…
Engineering Medicine Neuroscience

The Efficacy of Current Preventative Treatments Against the HPV Virus and Barriers to Adoption

Akshaya Santhanaraj Introduction: Two subtypes of the Human Papilloma Virus, HPV-16 and HPV-18, account for 50% and 10% of all cervical cancer cases respectively1. Preventative measures have been proven to be almost 100% effective against HPV-infiection2. However, two challenges still exist regarding the current HPV vaccine: a lack of therapeutic…
Engineering Medicine Microbiology

Enhancing the Precision and Safety of CAR Immune Cell Therapy through Tunable Biological Circuits

Neil Koby Reid Introduction. Chimeric Antigen Receptor (CAR) T-cell therapy is one branch of immunotherapy that is successful in treating refractory hematological malignancies1,2. Current CAR immune cells are host-specific cells that express transmembrane proteins that activate intrinsic immune cell pathways without the traditional MHC presentation. Newer generations of CAR therapies…
Engineering Medicine Immunology