Author: Priya Ramamoorthy

Combination CDK 4/6 Inhibitors and PI3K/AKT/mTOR Inhibitors Show Promise for Treating Triple Negative Breast Cancer

June 20, 2022 Priya Ramamoorthy
Priya Ramamoorthy Introduction:  Triple Negative Breast Cancer (TNBC) is breast cancer subtype with negative expression of estrogen, progesterone, and Human Epidermal Growth Factor Receptor-2.1 TNBC accounts for 15-20% of all breast carcinomas.2  TNBC neoplasms are often aggressive1 and highly heterogenous.2 Unlike for other breast cancer subtypes, there is a lack…
Cancer

HPV Infection Induces Secondary Mutations Resulting in Host Immune Defense Evasion and Oropharyngeal Cancer Abstract

June 20, 2022 Masen Ragsdale
Masen Ragsdale Introduction. In recent years, there has been a rise in the incidences of human papilloma virus-positive oropharyngeal cancer, especially in men.1,2 A persistent HPV 16 infection is responsible for 70% or more of oropharyngeal squamous cell carcinomas (OPSCC).1,2 Risk factors for developing this type of cancer include risky…
Cancer Microbiology

17β-Estradiol as a Method to Stimulate Angiogenesis in Mesenchymal Stem Cell Treatment for Hypoplastic Left Heart Syndrome

June 20, 2022 Allan Pulliam
Allan Pulliam Introduction. Hypoplastic left heart syndrome (HLHS) is the most common and one of the most severe/difficult to treat forms of congenital heart disease (CHD).1 Success of a series of three complex surgeries and therefore patient life expectancy are dependent upon the right ventricle’s ability to function as the…
Cardiology Featured Abstracts

The Use of Prognostic Biomarkers as an Indicator for Pulmonary Metastasectomy in Colorectal Cancer

June 20, 2022 Kerrington Powell
Kerrington Powell Introduction: Surgical metastasectomy is the removal of metastases from a primary tumor. Despite a high volume of procedures performed annually,1 a dearth of randomized controlled trial (RCT) evidence is available this procedure. Lack of RCT data has sparked controversy in the literature regarding risk-benefit profiles, particularly for pulmonary…
Cancer Cardiology

Elucidating IL-17 Signaling Involvement in the Pathogenesis of Alcoholic Liver Disease and Hepatocellular Carcinoma

June 20, 2022 Kieu Pham
Kieu Pham Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer.1 High alcohol intake has been linked to alcoholic liver disease (ALD), cirrhosis, and HCC.2 Because HCC usually occurs in patients suffering from known liver diseases like ALD, diagnosing HCC typically occurs through surveillance.2 Mechanistically, alcohol induces the…
Hepatology Neuroscience

The NLRP3 Inflammasome: a Factor in Alzheimer’s Disease Pathogenesis and a Potential Therapeutic Target

June 20, 2022 Aleksandr Pereverzev
Aleksandr Pereverzev Introduction. Alzheimer’s disease (AD) is the most common type of dementia1 and is characterized by amyloid-β (Aβ ) plaques, tau tangles, brain atrophy, and neuroinflammation2. The most accepted model of disease progression is the “amyloid-β cascade hypothesis” which identifies Aβ  deposits as the main cause of neurologic dysfunction1.…
Featured Abstracts Neuroscience