Redox Preconditioning Promotes the Survival of Cardiac Stem Cells Under Oxidative Stress After Transplantation

Melanie Kwan Introduction: Survival of cardiac stem cells (CSCs) after transplantation is necessary to facilitate cardiac repair following damage to the heart due to their potential ability to regenerate cardiomyocytes. The current best estimate of post-transplantation survival of CSCs is only approximately 10%.1 The primary cause of transplanted CSC death…
Cardiology Stem Cells

Pancreatic Epigenetics and hESC: Curing Type 1 Diabetes

Haseeb Khatri Introduction: Insulin secreted by pancreatic β cells play a large role in maintaining glucose homeostasis.1 Type I diabetes mellitus (T1DM) is a chronic autoimmune disease that impacts this homeostasis by destroying β cells, leading to hyperglycemia.2 Uncontrolled blood glucose levels can lead to multi-organ dysfunction.1 Current treatments include…
Endocrinology

Tau as a Therapeutic Target for Alzheimer’s Disease

Yo Sup Keum Introduction: Alzheimer’s Disease (AD) is a major age-related, progressive, neurodegenerative disorder and is the fourth leading cause of death in developed nations. Currently available medications and therapeutic options only treat the symptoms or have focused on ameliorating the symptoms as well as reducing the rate of progression…
Neuroscience

microRNA-25 as a treatment in heart failure

Ann Marie Karam Introduction: Heart Failure (HF) contributes to 1 in 8 deaths in America, with a risk of 1 in 5 of developing HF in one’s lifetime. In addition, HF can be difficult to diagnose, especially since most patients who develop HF have multiple comorbidities and present with varying…
Cardiology

Exercise Induced Changes on miRNA Expression and Its Effect on Cardiovascular Disease

Brittney Jackson Introduction: Cardiovascular diseases (CVD) are the leading cause of death in the United States and consume a significant amount of healthcare expenditures8. It is well researched and known that gene expression patterns are substantially altered in cardiac hypertrophy, myocardial infarction (MI), and heart failure5. microRNAs (miRNAs) are short…
Cardiology

The Role of Acetylation of Tau in Alzheimer’s Disease

Jason Hutzler  Introduction.  Alzheimer’s Disease (AD) is a progressive, and ultimately fatal neurodegenerative disorder that is currently the sixth leading cause of death in the United States, and the fifth leading cause of death for individuals over the age of 651. AD is characterized by, and can only be definitively…
Neuroscience

The Role of the Gut Microbiome in Mediating Obesity

Connie Hsiao  Introduction.  Obesity is a condition characterized by excessive adipose tissue and increases an individual’s risk for health, social and mental issues. Obesity is a major issue in the United States, where more than one- third of Americans are clinically obese (BMI ≥ 30 kg/m2).[1] Environmental and genetic factors…
Microbiology

Orthobiologics and the Role of Osteoinductive Proteins in Bone Repair: With Emphasis on Human Bone Morphogenic Protein (BMPs)

Garret Hisle  Introduction: The process of bone repair and the healing of bone fractures caused by trauma or disease has a significant clinical relevance due to the limited effectiveness in current treatment options. Among the Osteoinductive growth factors used for bone tissue stimulation, bone morphogenetic proteins (BMPs) are the most…
Orthopedics