Steven Maxwell – Page 53 – Proceedings of the Texas A&M Medical Student Grand Rounds

The Role of PI3k/Akt/mTOR Signaling Pathway in Mediating Poly(ADP-Ribose) Polymerase Inhibitor (PARP1) Resistance in BRCA-Deficient Ovarian Cancer Patients

July 28, 2021 Scott Mayo

Scott Mayo Introduction. Platinu-based chemotherapy resistance has been a major challenge in BRCA deficient ovarian cancer patients.4,5,6,7,8 BRCA deficient cancer cells have a decreased ability to repair double stranded DNA breaks. This single hit mutation is advantageous to the cancer cells, allowing for mutation to be sustained.5 Studies have shown…

Cancer

The Role of Brain Derived Neurotrophic Factor (BDNF) on Major Depressive Disorder

July 28, 2021 Jacqueline Le

Jacqueline Le Introduction: Major Depressive disorder (MDD) is a mood disorder characterized by sadness, isolation, and a loss of interest in parts of daily life. It occurs in women almost twice as often, and affects about 6% of the adult population worldwide. MDD is the 2nd leading cause of disabilities…

Featured Abstracts Psychiatry

The Role of WNT5a as a Regulator of Cystic Airspace Enlargement in Pulmonary Lymphangioleiomyomatosis

July 28, 2021 Ashley Kidwell

Ashley Kidwell Introduction. Pulmonary lymphangioleiomyomatosis (LAM) is a rare, lymphatic disease that affects 5-9 million women of child-bearing age.1,2 This is the second leading cause of mortality in women with tuberous sclerosis.3 Pulmonary LAM begins with a loss of function mutation in tuberous sclerosis complex 2 (Tsc2).1 This removes its…

Featured Abstracts Respiratory

Repeat Expansions in C9orf72 Leads to Mislocalization of TDP-43 Outside the Nucleus and the Mishandling of RNA by TDP-43 Leads to Sporadic ALS Formation

July 27, 2021 Mohamad Jabin

Mohamad Jabin Introduction. ALS is a progressive neurodegenerative disease whose hallmark is the gradual loss of upper and lower motor neurons and their pathways1. ALS has been reported to affect between 0.6 and 3.8 per 100,000 persons2. This disease is relentlessly progressive in most patients, with an average survival of…

Neuroscience

Mitigating Adverse Side Effects of Atypical Anti-Psychotic Drugs by Targeting the Histamine, H3, Receptor Subtype

July 27, 2021 Sabine Itani

Sabine Itani Introduction: Atypical antipsychotic drugs play a key role in the treatment of schizophrenia, bipolar disorder, and depression.1 In the US, over 50% of adults over the age of 70 use anti-psychotic drugs.2 Weight gain has been identified as one of the major side effects caused by atypical antipsychotic…

Uncategorized

The Role of Ryanodine Receptor 2 (RyR2) in Calcium Handling of Plakophilin-2 (PKP2) Deficient Arrhythmogenic Cardiomyopathy (ACM)

July 27, 2021 Rachel Inselmann

Rachel Inselmann Introduction. Arrhythmogenic Cardiomyopathy (ACM) is a leading cause of ventricular arrhythmias in previously healthy, young individuals which can result in Sudden Cardiac Death (SCD).1 Mutations in the desmosomal protein, Plakophilin-2 (PKP2), is the most common cause of ACM, resulting in dysfunction of cell-to-cell adhesions and intracellular gap junctions,…

Cardiology

Review of Modulation of Immune Signaling by Select Coxiella burnetii Effector Proteins

July 27, 2021 Samson Hennessy-Strahs

Samson Hennessy-Strahs Introduction. Coxiella burnetii, an intracellular bacterium and the causative agent of Q fever, can evade the immune system leading to acute or chronic infections. C. burnetii virulence is aided by its type IV secretion system (T4SS) to deliver effector proteins into the host cytoplasm. These proteins modulate host…

Immunology Microbiology

Gamma Entrainment: Activating Microglia to Reduce Aβ and Tau Pathology in Alzheimer’s Disease

July 27, 2021 Saman Hemani

Saman Hemani Introduction: Alzheimer’s Disease (AD) is a neurodegenerative disorder of aging that affects over 24 million people globally presenting primarily as a progressive loss of memory, language impairment, executive function, as well as hallucinations1-5. Sporadic AD typically presenting in older adults (70+)and occurs in 95% of AD cases, whereas…

Neuroscience

MDSCs Suppress the T Cell Immune Response in Multiple Myeloma

July 27, 2021 Jess Hatfield

Jess Hatfield Introduction. Multiple myeloma (MM) is a cancer of terminally differentiated plasma cells in the bone marrow and peripheral blood, and accounts for 10% of all hematological malignancies.1 MM symptoms occur when abnormal plasma cells secrete monoclonal proteins, or M proteins, in the bone and kidneys.1 In the MM…

Cancer Immunology

A673T Mutation in Amyloid Precursor Protein Decreases Amyloid Beta Production and Could Prevent Familial Alzheimer’s Disease

July 27, 2021 Rachael Hanson

Rachael Hanson Introduction. Alzheimer’s disease is a progressive neurodegenerative disease that affects nearly 50 million people worldwide and is the leading cause of dementia among elderly individuals.1 FAD makes up approximately 5% of AD cases, and is usually caused by a mutation in the APP gene.2 An A673T mutation in…

Neuroscience