Author: Shaili Tapiavala

The Role of a Western Diet in Regulating Expression of Farnesoid X Receptor and Colorectal Cancer Progression

July 31, 2019 Shaili Tapiavala
Shaili Tapiavala Introduction. Colorectal cancer is the third most common cancer in the Western world (1,4).  Today, colorectal cancer patients have an improving prognosis due to early detection, but colorectal cancer is still the third-leading cause of cancer-related deaths in America (1,4).  Colorectal cancer has been correlated with a high…
Cancer Nutrition

Tissue Transglutaminase 2 (TG2) Post-Translational Modification of the Angiotensin II Receptor (AT1R) Plays a Role in the Pathogenesis of Essential Hypertension

July 31, 2019 Eric Swanson
Eric Swanson Introduction. Hypertension (HTN) is the leading cause of stroke, disease burden and death worldwide (1) In the United States, it affects 46% of adults and it is estimated that 13-17% of adults with HTN have uncontrolled or resistant HTN (1).  Due to the underlying heterogeneity in the pathogenesis…
Cardiology Featured Abstracts

Where More is Less: Lysosomal Dysregulation in Response to PGRN Haploinsufficiency Leads to Upregulated C1qa and Synaptic Pruning in Frontotemporal Lobar Dementia

July 31, 2019 Jaqueline Stoutin
Jaqueline Stoutin Introduction. FTLD is a clinically heterogenous disease most often presenting with social disinhibition and apathy (1-5). FTLD is the second leading cause of early-onset dementia after Alzheimer’s Disease. There is currently no treatment for FTLD (1-4). In cases of PGRN haploinsufficiency, there is widespread lysosomal dysregulation: in microglia,…
Neuroscience

Targeting the Indoleamine 2,3-Dioxygenase Pathway to Suppress Pancreatic Ductal Adenocarcinoma Metastasis

July 31, 2019 Soumya Shekhar
Soumya Shekhar Introduction. Pancreatic ductal adenocarcinoma (PDAC) remains as one of the deadliest types of cancer, with 5-year survival rates remaining around 3% (1). PDAC tends to metastasize earlier than other types of cancer, so the efficacy of traditional first-line cancer treatments such as surgical resection and radiation therapy is…
Cancer Featured Abstracts

The Role of Placental IL-6 Signaling in MIA-induced Cerebellar Neuropathology: An Environmental Risk Factor for Autism Spectrum Disorders

July 31, 2019 Dina Sharhan
Dina Sharhan Introduction. Autism spectrum disorders (ASD) are multifactorial neurodevelopmental conditions characterized by varying deficits in social interaction (1). Incidence of ASD has increased dramatically over the past decade, and it is now estimated to affect 1 in 59 americans (2). Heterogeneity of ASD symptoms is thought to result from…
Neuroscience

The Role of Nrf2 in Alzheimer’s Disease

July 31, 2019 Jason Splawn
Jason Splawn Introduction. Nrf2 is a transcription factor that regulates numerous genes involved in cytoprotective processes (1). Nrf2 decreases as a function of age and is also reduced in Alzheimer’s Disease patients, although the exact mechanism for this is unknown (1). Evidence indicates that oxidative stress increases as a function…
Neuroscience