Category: Cancer

Inhibition of Wnt/beta-Catenin Signaling Promotes Susceptibility to Therapies in Castration Resistant Prostate Cancer

August 4, 2021 Alex Pham
Alex Pham Introduction: Castration resistant prostate cancer is a progression of prostate cancer that results when cancer cells develop mechanisms that enable them to stimulate their own androgen receptors.1 It is estimated about 10-20% of prostate cancers will progress to CRPC and the estimated mean survival of CRPC patients is…
Cancer Featured Abstracts

The Role of miRNA Influence on Tumor Associated Macrophages Polarization and Its Effects in Ovarian Cancer Chemoresistance

August 3, 2021 Heidi Pargas
Heidi Pargas Introduction: Ovarian cancer is a form of highly metastatic cancer that affects women aged 50-60 years old with Ashkenazi Jewish, Icelandic, or French decent1,2. Factors leading to the development of ovarian cancer are increased repeat of ovulation due to reactive oxygen species (ROS) causing DNA damage, and/or mutations…
Cancer Immunology

Targeting Exosomes for Pancreatic Cancer Therapy

August 3, 2021 Sharon Pan
Sharon Pan Introduction. Pancreatic adenocarcinoma (PDAC) is globally the 11th most common cancer, but is among the most lethal.1,2 Arising from pancreas exocrine tissue responsible for production and secretion of digestive enzymes, PDAC has a 6-month median survival and 8% 5-year survival.3,4 Barriers to early detection due to non-specific presenting…
Cancer

Chemoresistance in Neuroblastoma: Annexin A2 as a Key Regulator of Apoptosis and the Epithelial-to-Mesenchymal Transition and as a Potential Therapeutic Target

August 3, 2021 Kaci Orr
Kaci Orr Introduction. Neuroblastoma (NB) is a neoplasm of the peripheral nervous system.1,2 It is the most common and deadliest extracranial tumor of childhood, with approximately 650 cases diagnosed annually in the United States.1 More than 50% of patients present with a metastasized tumor and are classified as high risk.3…
Cancer

Estrogen Receptors in the Regulation of Castration-Resistant Prostate Cancer

August 3, 2021 Ella Nonni
Ella Nonni Introduction: Androgen deprivation therapy is the mainstay of prostate cancer (PCa) treatment1, however nearly all cases of PCa will eventually become androgen independent or “castration-resistant” (CRPC), at which point five-year survival rates drop from 95% to 28% 2. The mechanisms by which prostate tumors continue to proliferate in…
Cancer

Microbiota-Derived Acetate Upregulates Metabolic Genes in Hepatocellular Carcinoma

August 3, 2021 Chanyanuch Nakapakorn
Chanyanuch Nakapakorn  Introduction: Hepatocellular carcinoma (HCC) is ranked 3rd in cancer mortality in developed countries with poor prognosis.1 Higher risk of developing HCC is associated with hepatitis B or C, alcohol-related liver damage, metabolic diseases, and mutations.1,8 Commonly, patients are diagnosed by biopsy but are often asymptomatic resulting in late…
Cancer Microbiology

DNMT-Mediated Pathways in the Progression, Immune Regulation, and Drug Resistance of Multiple Myeloma Indicate the Potential of DNA Methylation Inhibitors

August 2, 2021 Lynnsey McLain
Lynnsey McLain  Introduction. Multiple myeloma is a malignancy of plasma cells in the bone marrow, resulting in the excessive production of non-functional immunoglobulins.1 The incidence of multiple myeloma in the US is approximately 4 per 100,000 people, which accounts for more than 10% of all hematological malignancies and 1% of…
Cancer Immunology