Using CRISPR Cas9 Gene Editing to Generate CAR (Chimeric Antigen Receptor) T-Cells for Immunotherapeutic Treatment of Leukemia

Jeffrey Cao Background: Leukemia is a cancer in which blood-forming tissues like bone marrow generate high numbers of immature or abnormal leukocytes, suppressing the production of normal blood cells. Like most cancers, malignant cells in leukemia exhibit immune evasion and resist checkpoint inhibition, which pose challenges to therapy. To overcome…
Cancer Immunology

The Role of Sulforaphane in the Chemoprevention of Prostate Cancer

Antony Mathew Prostate cancer is the second most common cancer in men worldwide and the second leading cause of cancer related mortality. The major identified risk factors for development of prostate cancer include age, family history and race. Current treatment regimens lead to mixed results due to many varying risk…
Cancer

Cancer Killer: The Role of Amiloride Derivatives in the Selective Targeting and Killing of Breast Cancer Cells

Tanner Lines Introduction: Breast cancer is the most common malignancy in women and the third most common cancer worldwide behind lung and colon cancer1,2. Triple-negative breast cancer (MDA-MB-231) represents 10-20% of all breast cancer cases and lacks the progesterone, estrogen, and HER2 receptors that serve as targets for breast cancer…
Cancer Featured Abstracts

LncRNA H19 functions as a decoy for multiple miRNA families to derepress epithelial-to-mesenchymal transition and promote cancer progression.

Lyndon Lee Introduction: Epithelial-to-mesenchymal transition (EMT) is implicated in the acquisition of an invasive and treatment resistant phenotype in cancer, and is characterized by the loss epithelial characteristics.1-3 Mesenchymal characteristics include the gain of a leading/trailing edge, upregulation of mesenchymal markers and the formation of migratory protrusions.1-3 Transforming growth factor…
Cancer Featured Abstracts

Ang-2 and VEGF Inhibition alters tumor associated macrophages and normalizes tumor vasculature in glioblastoma

Tejaswini Reddy  Introduction: Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults and the current standard of treatment of care is surgical resection of tumor(s) followed by external beam irradiation and taking cytotoxic agent temozolomide orally [1-6]. However, many tumors develop resistance to temozolomide, which is why…
Cancer Featured Abstracts