Category: Cancer

Fusobacterium nucleatum Downregulates miR-4802 and miR-18a* to Promote Autophagy-Mediated Chemotherapeutic Resistance in Colorectal Cancer

July 27, 2021 Roger Garcia
Roger Garcia Introduction. Colorectal cancer (CRC) ranks third in incidence and second in mortality among all cancers globally1. Among patients diagnosed with CRC, 40% present with recurrence after treatment2. The gut microbiota can modulate CRC cellular mechanisms that promote resistance; specific host-pathogen interactions driving such resistance are under investigation3. Fusobacterium…
Cancer Featured Abstracts Microbiology

Bispecific CAR T-Cell Therapy As A Mechanism to Overcome Antigen Escape Relapse in Non-Hodgkin’s Lymphoma

July 26, 2021 Timothy Davis
Timothy Davis Introduction.  Non-Hodgkin Lymphoma (NHL) is a cancer of lymphocytes that has 60-70% survival rate and a poor prognosis in patients with relapsed or refractory disease.1,2 Therefore, new therapeutic approaches are urgently needed.1,2 The vast majority, 85-90%, of NHLs have B-cell origin1,2 and express the antigens CD19 or CD20.1,3 …
Cancer Featured Abstracts Immunology

R-loop Dependent Formation of Helicobacter pylori-Induced Gastric Cancer using the NF-κB Pathway and Possible Therapeutic Targets

July 23, 2021 Andrew Cassity
Andrew Cassity Introduction. Helicobacter pylori-induced gastric cancer accounts for 75% of gastric cancer cases worldwide and disproportionately affects developing countries.1 It is usually found in late stages when treatment options have low efficacy.2 This is a result of limited knowledge about how H. pylori causes gastric cancer. Studies show that…
Cancer Microbiology

Overexpressed H19 lncRNA represses miR29b-3p and is associated with poorer prognoses and overactive Wnt/Beta Catenin signaling in colorectal cancer

July 23, 2021 Sahar Baig
Sahar Baig Introduction. Colorectal cancer (CRC) is one of the most common causes of cancer mortality in the US, accounting for around 850,000 deaths annually¹. Many of these deaths–up to 90%–are associated with metastatic CRC¹. Cancer cell detachment and migration that leads to metastasis is preceded by several changes in…
Cancer

Therapeutic use of LncRNA NKILA in triple negative breast cancer metastasis through prevention of TGF-β and NF-κB signaling-induced EMT

July 23, 2021 Abigail Bagdasaryants
Abigail Bagdasaryants Introduction. Breast cancer is the leading cause of cancer mortality in women worldwide. Triple negative breast cancer (TNBC) is an aggressive subtype with higher rates of metastasis, higher probability of relapse, and poorer patient outcomes.1 TNBC presents more commonly in younger, Black, and Hispanic patients, and is characterized…
Cancer

Therapeutic and Imaging Implications of STEAP in Metastatic Castration-Resistant Prostate Cancer

July 23, 2021 Priscilla Anderton
Priscilla Anderton Introduction. Prostate cancer is the second most common cancer diagnosed in men world-wide.1 The pathology is driven by genetic mutations, resulting in unregulated growth of the prostatic epithelial cells.1 Initial treatment includes prostatectomy and androgen deprivation therapy.1 Metastatic castration resistant prostate cancer (mCRPC) is cancer that progresses despite androgen…
Cancer

MicroRNA-Containing Exosomes Promote AML Pathogenesis Via Stromal Remodeling and Suppression of Normal Hematopoiesis

July 23, 2021 Matthew Anaya
Matthew Anaya Introduction. Acute myeloid leukemia (AML) is the most common acute leukemia in adults.1 It results from an abnormal accumulation of myeloblasts and is associated with a wide variety of genetic mutations.2 Symptoms include recurrent infection, anemia, and bleeding.3 The median age of diagnosis is 68 years and the…
Cancer Featured Abstracts