Cancer – Page 15 – Proceedings of the Texas A&M Medical Student Grand Rounds

Role of PD-L1 in Temozolomide (TMZ) Resistant Glioblastoma (GBM) Acting Mechanistically Through A TRAF6/STAT Pathway

July 21, 2021 Preston Adhikari

Preston Adhikari Introduction. Glioblastoma (GBM), accounting for almost 80% of all malignant brain tumors, is one of the most aggressive and lethal tumors with a median survival time of only 12-15 months, and a five-year survival rate close to zero1,4. Due to the physiological and pathological properties of GBM, the…

Cancer

The Role of Brd4 in the pathogenesis of Gastric Cancer by Cag+ H.pylori

July 21, 2021 Daisy Abraham

Daisy Abraham Introduction: H.pylori is a bacteria that colonizes the gut of 50% of humans.7 Infection with Cag+ H.pylori is a primary cause of gastric cancer, which is the fourth leading cause of cancer-related death globally.8 Chemotherapy is a common treatment, but chemoresistance by cancers through the inhibition of apoptosis is…

Cancer Microbiology

Role of IDH1-R132H in tumor progression of gliomas

April 8, 2021 Khalid Alhreish

Khalid Alhreish Introduction: Gliomas represent the most common primary brain tumor in adults1. They remain incurable despite current therapies, which are plagued by high morbidity and mortality. The isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) genes are mutated in 50-80% of astrocytomas, oligodendrogliomas or oligoastrocytomas of grades II and III,…

Cancer

Role of Androgen Receptor Variant 7 in progression to Castration Resistant Prostate Cancer

October 28, 2020 Jay Hofweber

Jay Hofweber Introduction. Prostate cancer (PC) is the second-leading cause of cancer-related death among males in the United States.1 10-20% of prostate cancer patients develop castration-resistant prostate cancer (CRPC) within approximately 5 years with a median survival from 9 to 30 months.2 Progression to CRPC results from failure of androgen…

Cancer

Early life exposure to soy affects breast cancer susceptibility through regulation of ER and cytokines

October 12, 2020 Bailey King

Bailey King Introduction. Breast cancer is the most common non-cutaneous cancer in women in the US. Studies have found significant differences in the microbial composition between breast cancer patients and non-breast cancer patients.1 The diet affects breast cancer risk through multiple mechanisms, including estrogen and cytokines. Estrogens influence mammary gland…

Cancer Nutrition

Tumor Induced Platelet Aggregation Promote Tumor Growth Through the Podoplanin/CLEC-2 Pathway

August 11, 2020 Timothy Yadegar

Timothy Yadegar Introductions. Cancer is a major public health problem worldwide and is the second leading cause of death in the United States1. Different types of cancers have different symptoms, either specific to the cancer or general to a variety of illnesses2. This make it more difficult to catch a…

Cancer

Structural Mechanisms of PD-1 – SHP2 Signaling

July 7, 2020 Eric Zhang

Eric Zhang Introduction: Colorectal cancer (CRC) is the 3rd most common cancer globally, and the 4th most common cause of cancer mortality1. Inflammatory bowel disease (IBD) ranks as a major predisposing factor for the development of CRC, termed colitis-associated colorectal cancer (CAC) when caused by inflammatory etiologies2. Src homology region…

Cancer

The Role of Selected MicroRNAs (miRNAs) in the Negative Regulation of Pediatric Retinoblastoma Progression

July 7, 2020 Ashtyn Zapletal

Ashtyn Zapletal Introduction. Retinoblastoma (Rb) is an autosomal dominant retinal cancer usually affecting children ages 15 months – 24 months, counting for roughly 9,000 new cases each year.1,2 Common treatments for Rb include intra-ophthalmic and intra-vitreal chemotherapy, as well as enucleation3. To mitigate the harsh side effects of these current…

Cancer

Efficacy of Calreticulin of the Unfolded Protein Response as a Drug Target in HNSCC

July 7, 2020 Jay Young

Jay Young Introduction: HNSCC has emerged as one of the major chemo-resistant and aggressive cancer subtypes4. Among prevalent cancers, it has one of the lower 5-year survival probabilities at less than 50%5. While the molecular mechanism behind treatment-resistant HNSCC has been revealed, the clinical applications of the research remains in…

Cancer

The Therapeutic Use of HIF Pathway Inhibitors to Reduce Castrate Resistant Prostate Cancer

July 7, 2020 Gabrielle Young

Gabrielle Young INTRODUCTION: Prostate cancer (PC) is the leading cause of cancer related death of men in American, and castration resistant prostate cancer (CRPC) is the major mortality determinant; therefore, it has a lot of importance.1,2 Previous studies conducted have verified the importance of the hypoxia inducible factor (HIF) pathway…

Cancer