Category: Cancer

The Implications of Differences in Spatial Distribution of LGR5 in Colorectal Cancer Adenomas as an Indication of Variations in Wnt Pathway Signaling Amount

July 16, 2019 Kelley Liao
Kelley Liao  Introduction: Colorectal cancer (CRC) is the second leading cause of cancer related deaths in the US. Cancer stem cells (CSC) are widely understood to be drivers of tumor progression and thus play an important role in the metastasis and development of CRC.1 LGR5, a seven-transmembrane domain G protein-coupled…
Cancer

The Role of Inflammatory Response Element CTBP1 in Metabolic Syndrome and Prostate Cancer Metastasis

July 16, 2019 Katherine Lawrence
Katherine Lawrence  Introduction: Prostate Cancer (PCa) has a higher prevalence of metastasis in obese patients, which is thought to be a result of increased inflammation causes by obesity and metabolic syndrome, particularly a higher prevalence of visceral fat.1 When immunodeficient mice were used as a model for prostate tumor progression,…
Cancer Inflammation

MiR-34a Suppresses p53-Mediated Tumorigenesis and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer

July 16, 2019 Ariane Kubena
Ariane Kubena Introduction. Lung cancer is the leading cause of cancer-related deaths worldwide, and 85% of cases are diagnosed as Non-Small Cell Lung Cancer (NSCLC). 70% of NSCLC diagnoses present at an advanced stage with a 15% 5-year survival rate and chemotherapeutic resistance9. Research has shown that miR-34a is downregulated…
Cancer Featured Abstracts

PARP Inhibitor as Adjuvant Therapy for Glioblastoma

July 16, 2019 Yongchang (Ryan) Jang
Yongchang (Ryan) Jang Introduction. Glioblastoma Multiforme (GBM) is the deadliest form of brain cancer in adults which is also the most common form of malignant CNS tumor.7,11 Though the therapeutic advances, prognosis for GBM is still poor with 15-month median overall survival.6,10 Temozolomide, a common anti-neoplastic agent for GBM, induces…
Cancer

Therapeutic Paradigms That Target Glioblastoma Multiform (GBM) Tumor Metabolism and Available Substrates for Glycolysis in the Tumor Microenvironments (TME)

July 16, 2019 Donya Iranpoor
Donya Iranpoor Introduction. Glioblastoma Multiforme (GBM), is a Type IV astrocytoma and has the highest incidence of all malignant brain tumors. The estimated median survival time for patients diagnosed with GBM is 12 to 15 months. Current treatment options consist of neurosurgery, radiation, and temozolomide chemotherapy.1 Within the cellular heterogeneity of…
Cancer