Obesity-associated deoxycholic acid promotes hepatocellular carcinoma by provoking senescence associated secretory phenotype in hepatic stellate cells via the mTOR signaling pathway
Lamees El Nihum Introduction. Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and third in cancer-related death1. Five-year survival rates of patients undergoing curative therapies including liver transplant and hepatic resection range between 40-75%1. Hepatic fibrosis, a response to chronic inflammation, is the strongest predisposing factor for HCC…