Cancer – Page 3 – Proceedings of the Texas A&M Medical Student Grand Rounds

The Epigenetic DNA Methylation Changes Associated with Human Papillomavirus Uterine Cervical Cancer

June 22, 2023 Roxana Farokhnia

Roxana Farokhnia Background: Uterine cervical cancer (UCC) is the 4th most common cancer in women, and nearly all cases are caused by a human papillomavirus (HPV) infection.1 Although prevention and early detection of UCC are available through vaccines and outpatient diagnostic tests, some cases of UCC are not detected until…

CircFNDC3B Suppresses Colorectal Cancer Progression Through Inhibition of Angiogenesis

June 22, 2023 Logan Rivera

Logan Rivera Background: Colorectal cancer is a prevalent neoplasm affecting the rectum and colon, accounting for approximately 10% of cancer diagnoses and being the third leading cause of cancer-related deaths globally. The disease presents with symptoms such as abdominal pain, weight loss, and blood in the stool. Diagnosis involves imaging…

Cancer

Triple Combination Therapy of CDK4/6 Inhibitors, Endocrine Therapy, and mTOR/PI3K Inhibitors to Treat Hormone Receptor-Positive Human Epidermal Growth Factor Receptor-2 Negative Breast Cancer with Acquired Resistance

June 22, 2023 Rebecca Waugh

Rebecca Waugh Background: In America breast cancer is the most frequently diagnosed malignancy in women2,5. Hormone receptor-positive human epidermal growth factor receptor-2 negative (HR+/HER2-) tumors categorize 65-70% of all cases and has one of the lowest survival rates1,2. Recent meta-analysis incorporate modulation CDK 4/6 inhibitors (CDKi) with endocrine therapy as…

Cancer Endocrinology Featured Abstracts

The Mechanism and Treatment of Pediatric Low-Grade Glioma and Optic Glioma in children with Neurofibromatosis Type 1

June 22, 2023 Talia Meidan

Talia Meidan Background: Neurofibromatosis Type 1 (NF1) is an autosomal dominant genodermatotic and tumor predisposition disorder characterized by a mutation in the NF1 gene, a regulator of the RAS/MAPK pathway.1,2 Patients with NF1 are predisposed to CNS tumors, with 15-20% developing gliomas. Moreover, approximately 15% of children with NF1 develop…

Cancer Featured Abstracts

The Potential Use of CDK7 Inhibitors to Treat Metastatic Castration-Resistant Prostate Cancer via Reduction in MED1 Phosphorylation and Androgen Receptor Signaling.

June 21, 2023 Michael Hembrough

Michael Hembrough Background: Prostate cancer (PC) is the most common malignancy in men. 1,2 PC begins with mutations in prostatic ductal epithelial cells, which produce androgen receptor (AR), a transcriptional regulator for genes controlling cell homeostasis. 1 These mutations increase AR signaling, driving tumorigenesis and metastasis. 2 Eventual progression to…

Cancer Endocrinology Featured Abstracts

Canonical Wnt Signaling as a Driver of Oncogenesis and Therapeutic Target in Osteosarcoma

June 21, 2023 Michael Fowler III

Michael Fowler III Background: Although it is a rare cancer, osteosarcoma (OS) is the most common primary malignancy of bone. These tumors are of mesenchymal origin and most often arise out of the metaphyseal growth plates of long bones and their highest incidence occurs during the pubertal growth spurt in…

Cancer Featured Abstracts

Hypoxia-Induced Resistance of Triple Negative Breast Cancer (TNBC) to Chemotherapy and Anti-PD-1 Therapy

June 21, 2023 Lexi Goehring

Lexi Goehring Background: Breast Cancer is the second most common cancer affecting women globally. While breast cancer generally has a high survival rate, Triple Negative Breast Cancer is a subtype that has a 50% recurrence rate in the first three to five years after diagnosis, and metastatic TNBC has a…

Cancer Featured Abstracts Immunology

Vitamin D Inhibits the Pro-Tumorigenic Functions of Cancer-Associated Fibroblasts in Colorectal Cancer

June 21, 2023 Lauren Wilkin

Lauren Wilkin Background: Colorectal cancer (CRC) is the third most common cancer and the second most deadly cancer in the United States, thus improvements in treatment are of increasing interest.1 The current treatment for stage I and II CRC is surgical resection, but once the cancer has metastasized, indicating stage…

Cancer Featured Abstracts

Fusobacterium nucleatum and Its Role in Modulating Autophagy in Colorectal Cancer

June 21, 2023 Laura Kim

Laura Kim Background: Colorectal cancer is the collective term for colon and rectal cancer. It is the second most lethal cancer and the third most common cancer worldwide.1,2,3 Right now, the most effective treatment for these patients is to use standard chemotherapy, typically 5-fluorouracil and oxaliplatin.2 These patients are initially…

Cancer Featured Abstracts Microbiology

The Role of Dysregulated Signaling Pathways In The Development of Hepatocellular Carcinoma

June 21, 2023 LaShawn Oyibo

LaShawn Oyibo Background: Hepatocellular carcinoma (HCC) is a primary liver cancer that develops from hepatocytes, which are the liver’s parenchymal cells.1 It is the most common primary liver cancer and is also the fifth most common type of cancer, accounting for almost 10% of all cancer cases.2 Current treatments for…

Cancer Featured Abstracts Hepatology