Category: Cardiology

A Comparison of Fluid-Structure Interaction (FSI) Modeling to Rigid-Wall Computational Fluid Dynamics (CFD) in Aortic Dissection

June 22, 2023 Ahmad Tabatabaeishoorijeh
Ahmad Tabatabaeishoorijeh Introduction: Aortic dissection is the number one disease affecting the human aorta. Computational modeling has recently been utilized to better understand the hemodynamics parameters associated with aortic dissection. However, more accurate risk prediction models are needed to better understand the prognosis of the disease in aortic dissection patients.…
Cardiology Engineering Medicine

Anti-VEGF Therapies as Potential Treatment Option for Arteriovenous Malformations

June 22, 2023 Christopher Chaftari
Christopher Chaftari Background:  Arteriovenous malformations (AVM) are characterized by an abnormal connection between an artery and a vein, bypassing a capillary bed; this leads to a high velocity, low resistance flow which may cause serious complications like stroke, brain abscess and hemorrhage.1,2,3 Current treatment options include surgical interventions aimed to…
Cardiology Engineering Medicine Featured Abstracts

The role of TnT-I79N in the Upregulation of Calcium Channels Leading to Hypertrophic Cardiomyopathy Associated Sudden Cardiac Death Risk

June 22, 2023 Shourya Kashyap
Shourya Kashyap Background: Hypertrophic Cardiomyopathy (HCM) is a monogenic inherited cardiac disease that has a prevalence of 1/500 and is present in over 60 countries in all continents.1,2The disease is caused by a genetic mutation (mostly missense) that disrupts the genetic coding of cardiac sarcomeres.1While advanced cases are clinically diagnosable…
Cardiology Featured Abstracts

The Use of Conductive Biomaterials For Cardiac Tissue Engineering To Treat Post Myocardial Infarction Cardiac Fibrosis

June 22, 2023 Steven Maxwell
Eshan Sayani Background: Myocardial infarction (MI) is a common condition that can lead to cardiac fibrosis and heart failure1,2,3,4,5,6. Current treatments have limitations in targeting fibrotic tissue and there are no reliable biomarkers to predict the development or severity of fibrosis1,2,3. The lack of effective treatments for established post-MI cardiac…
Cardiology

Mutations of the NOTCH1 Signaling Pathway Constitute Congenital Cardiac Anomalies in patients with Tetralogy of Fallot

June 22, 2023 My Lai
My Lai Background: Tetralogy of Fallot is the one of the most common cyanotic congenital heart diseases, affecting 3 out of 10,000 infants yearly.1 Tetralogy of Fallot (TOF) features 4 significant hallmarks, including ventricular septal defect (VSD), aorta overriding VSD, pulmonary stenosis, and right ventricular hypertrophy. 2,3 Current successful treatment…
Cardiology Development Featured Abstracts

Increased Gene Expression of Nuclear Factor PPARγ Through Exercise and Use of Modulator Drugs May Reduce Risk of Coronary Artery Disease

June 21, 2023 Emaan Hassan
Emaan Hassan Background:  The heart is made up of three layers: epicardium, myocardium, and endocardium. Epicardial adipose tissue (EAT) is the accumulation of adipose tissue between the epicardium and myocardium.[1] EAT surrounds major coronary vessels and is in close relation to the cardiomyocytes in the myocardial layer. EAT shares the…
Cardiology

Silk-Based Fibroin Vascular Grafts for The Repair and Regeneration of Small Caliber Blood Vessels In Cardiovascular Disease

June 21, 2023 Manusree Bhatter
Manusree Bhatter Background: Cardiovascular diseases (CVDs) are a leading cause of death globally, accounting for almost 19 million deaths globally1. Coronary Artery Disease (CAD) is a lethal CVD, and it accounts for approximately 610,000 death every year in the United States and is a major source of healthcare costs2. CAD…
Cardiology Featured Abstracts

Inflammatory Response and Regulation of T-lymphocytes Involved in Cardiac Remodeling Impacting the Severity of Ischemic Cardiomyopathy

June 21, 2023 Katelyn Rook
Katelyn Rook Background: Ischemic heart diseases cause an estimated 17.9 million deaths annually, with most of these cases involving myocardial infarction (MI) of left ventricular (LV) cardiac tissue1. Following an acute MI, the immune system coordinates an inflammatory response to clear damaged tissue and promote wound healing2. As a result…
Cardiology Immunology Inflammation