Multi-Organ System Signaling Converges on Resident Cardiac Macrophage Kruppel-Like Factor 4 to Preserve Cardiac Function During Heart Failure
Jacob Kuempel Background: Heart failure affects over 23 million people globally and is the leading cause of mortality worldwide.1 Heart failure with reduced ejection fraction (HFrEF) has the worst prognosis of the 3 clinical subtypes of heart failure and accounts for ~50% of all heart failure cases.1 Increasing global incidence…