Cardiology – Page 5 – Proceedings of the Texas A&M Medical Student Grand Rounds

IL-6 Signaling in Pulmonary Arterial Hypertension as a Potential Therapeutic Target

June 23, 2022 Michael D. Woods

Michael D. Woods Introduction. Pulmonary arterial hypertension (PAH) is a rare chronic disease characterized by a mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg in the setting of pulmonary vascular disease.1 Chronic inflammation drives the endothelium and pulmonary artery smooth muscle cells (PASMC) to resist apoptosis, proliferate, and migrate, resulting…

Cardiology Featured Abstracts

Methods of Intervention in Cardiac Hypertrophy with a Focus on M6a Methylation

June 22, 2022 Jeswin Vennatt

Jeswin Vennatt Introduction. When the heart undergoes stress stimulation such as a myocardial infarction or pressure overload, it undergoes hypertrophic growth.1 This initial cardiac remodeling is so that the heart can match the increase in stress, however, it is also the primary reason for heart failure.1 Cardiac hypertrophy is heavily…

Cardiology

Using Allele-Specific RNA Silencing of MYH7 to Treat Hypertrophic Cardiomyopathy

June 21, 2022 Kade Scoresby

Kade Scoresby Introduction. Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiomyopathy, affecting about 1 in 500 people.1 HCM is genetically inherited, with mutations in the MYH7 (β-myosin heavy chain protein) and MYBPC3 (myosin-binding protein C) genes accounting for approximately 70% of HCM cases.2,3 The most common HCM treatments include…

Cardiology

CCR5 Inhibition After Stroke Improves Motor and Cognitive Function through Enhanced CREB/DLK Signaling

June 21, 2022 Kiran Sankarappan

Kiran Sankarappan Introduction. Stroke is the fifth leading cause of death and a leading cause of disability in the United States, affecting 800,000 individuals annually.2 The brain is a notable utilizer of oxygen and stroke occurs when an obstruction of an artery prevents blood and oxygen from reaching a certain…

Cardiology Featured Abstracts

Increased Understanding of MYBPC Mutations Leads to Potential Therapeutics for Patients with Familial Hypertrophic Cardiomyopathy

June 21, 2022 Jessica Saganowich

Jessica Saganowich Introduction: Familial hypertrophic cardiomyopathy (FHCM) is defined by having a left ventricular wall thickness greater than 15mm not due to secondary causes.1 FHCM is cuased by inherited mutations in sarcomere genes.2 The most commonly inherited mutations are in Myosin Binding Protein C (MYBPC).2 Patients with FHCM experince symptoms…

Cardiology Featured Abstracts

The Cardio-Protective Role of the Clock Gene Following Myocardial Infarction

June 21, 2022 Daniaal Saeed

Daniaal Saeed Introduction: Myocardial infarction (MI) results from prolonged ischemia to the myocardium of the heart caused by stenosis of the coronary arteries that perfuse the heart.1,2 Despite the fact that MI is an acute event, many long-term lifestyle factors such as environment, diet, genetics, exercise habits, and even gender…

Cardiology Circadian Rhythms

: The role of Isolevuglandins and Pro-Inflammatory Cytokines on Antigen Presenting Cell-Induced Hypertension

June 21, 2022 Shahbaz Saad

Shahbaz Saad Introduction: Hypertension is a condition that affects over 1 billion people.2 It is a leading cause of death worldwide. Hypertension is defined by systolic blood pressure being greater than 140 mm Hg and diastolic blood pressure being > 90 mm Hg9,10 Men are generally more affected than women,…

Cardiology Immunology Inflammation

The Role of CD4+ T-Cell Endogenous Cystathionine Gamma Lyase in the Proliferation and Differentiation of T Regulatory Cells in the Attenuation of Hypertension

June 20, 2022 Colten Rowan

Colten Rowan Introduction. Hypertension is defined as blood pressure greater than or equal to 140/90 mmHg and occurs in 25-43% of the global population older than 18 yr1. In the vast majority of patients, the explicit etiology is unknown and is defined as primary or essential hypertension1. Despite advances in…

Cardiology Immunology

17β-Estradiol as a Method to Stimulate Angiogenesis in Mesenchymal Stem Cell Treatment for Hypoplastic Left Heart Syndrome

June 20, 2022 Allan Pulliam

Allan Pulliam Introduction. Hypoplastic left heart syndrome (HLHS) is the most common and one of the most severe/difficult to treat forms of congenital heart disease (CHD).1 Success of a series of three complex surgeries and therefore patient life expectancy are dependent upon the right ventricle’s ability to function as the…

Cardiology Featured Abstracts

The Use of Prognostic Biomarkers as an Indicator for Pulmonary Metastasectomy in Colorectal Cancer

June 20, 2022 Kerrington Powell

Kerrington Powell Introduction: Surgical metastasectomy is the removal of metastases from a primary tumor. Despite a high volume of procedures performed annually,1 a dearth of randomized controlled trial (RCT) evidence is available this procedure. Lack of RCT data has sparked controversy in the literature regarding risk-benefit profiles, particularly for pulmonary…

Cancer Cardiology