TRPV4 Calcium Ion Channels Act as Potential Target for Preventing Myocardial Fibrosis
Harshith Dasara Introduction. Myocardial fibrosis is the abnormal expansion of myocardium due to excessive deposition of extracellular matrix via activation of fibroblasts.1 Despite fibrosis having a critical role of preserving structural integrity following myocardial infarction (MI), increased future susceptibility for heart failure is the result.2,3 Every year, over 700,000 Americans…