TRPV4 Calcium Ion Channels Act as Potential Target for Preventing Myocardial Fibrosis

Harshith Dasara Introduction. Myocardial fibrosis is the abnormal expansion of myocardium due to excessive deposition of extracellular matrix via activation of fibroblasts.1 Despite fibrosis having a critical role of preserving structural integrity following myocardial infarction (MI), increased future susceptibility for heart failure is the result.2,3 Every year, over 700,000 Americans…
Cardiology

Elucidating the Mechanism of Endothelium-Dependent Coronary Microvascular Dysfunction Linked to Diastolic Dysfunction with Heart Failure

Vy Dang Introduction. Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for 50% of all HF cases, affecting ~2.5 million patients in 2019. Individuals with HFpEF present typical signs and symptoms of HF such as shortness of breath, edema, fatigue, left ventricle (LV) hypertrophy, and diastolic dysfunction.2 LV hypertrophy…
Cardiology

The Role of Type I Interferons in Congenital Heart Block

Colin Chan Introduction. Congenital heart block (CHB) is an autoimmune disorder with high fetal morbidity and mortality.1 CHB is caused by placental transcytosis of maternal IgG antibodies that act against ribonucleic complex Ro and La leading to pathogenic inflammation in fetal hearts culminating in complete heart block.2,3 Most children require…
Cardiology Immunology

The Role and Consequences of Methadone, in the Face of the Ongoing Opioid Crisis, on the hERG Channel in Prolonged QT Interval

Austin Hughes Introduction. Prolonged QT interval results from genetic or acquired causes, characterized by prolongation of the QT interval, the period from onset of cardiac ventricular depolarization to the end of ventricular repolarization.1  Drug-induced QT prolongation is common among recovering opioid dependents, particularly in those who are prescribed racemic methadone, the…
Cardiology Psychiatry

Utilizing Vessel Visualization through Fluorescent Tracers, such as Indocyanine Green Fluorescence, to Evaluate Integrity of Vasculature Intraoperatively and Reduce Complication Rates

Robert Loving Introduction. During surgical operations, greater understanding of a patient’s specific blood flow to an area and additional information allowing for a more complete understanding of the areas vasculature allows surgeons so make the most informed decision and produce better outcomes for their patients1,2. Most methods of vessel visualization…
Cardiology Engineering Medicine

COVID-19 Cytokine Storm Causes Myocarditis Characterized by Reduced Cardiac Function, Fibrosis, and Increased Mortality

Brianna Cathey Introduction. Myocarditis is the most frequent manifestation of COVID-19 cardiac involvement, causing up to 7% of COVID related deaths.1,2 Cardiac injury occurs in approximately 12% of patients and has shown a 51% mortality rate in hospitalized COVID-19 patients.3 While it has been established that COVID-19 particles enter the…
Cardiology Microbiology

Utilization of Machine Learning/Artificial Intelligence-Assisted Neuroimaging to Direct Treatment and Predict Outcomes in Ischemic Stroke

Caleb Haeussler Introduction. Ischemic stroke is a leading cause of morbidity and mortality in the United States, with an incidence of 700,000 ischemic strokes per year and 4 million stroke survivors.1,2 Ischemic stroke is a result of decreased blood flow to the brain, usually as result of thrombosis, embolism, or…
Cardiology Engineering Medicine Neuroscience

Therapeutic Treatments of Ischemic Strokes

Alwin Mathew Introduction. A stroke is a neurological deficit caused by a lack of blood flow to an area of the brain. It is the second leading cause of death and the third leading cause of disability in adults.8 Neuroimaging is key to differentiate between ischemic and hemorrhagic strokes.4 Ischemic…
Cardiology

The Role of H19 and Other Long Non-Coding RNAs in Cardiac Hypertrophy: Novel Treatment and Prevention Strategies for Hypertrophic Cardiomyopathy

Matthew Wooten Purpose. Hypertrophic Cardiomyopathy (HCM) is characterized by abnormal hypertrophy of the heart, often with preference of the interventricular septum.1, 2 It’s prevalence is as high as 1 in 500 adults, and is the most common cause of sudden cardiac death in young athletes.1 It is typically caused by…
Cardiology

The Effect of Cyclooxygenase 2 and E-Prostanoid Receptor 3 Inhibition on the Prostaglandin E2/E-Prostanoid Receptor Pathway in Salt-Sensitive Hypertension

Jessica Watson Introduction. Hypertension is defined as blood pressure persistently elevated above 130/80 mmHg.1,2 It is the most important modifiable risk factor for cardiovascular disease and affects 874 million people worldwide.­­1 Thirty to fifty percent of hypertensive patients exhibit salt sensitive hypertension, which is best defined as a direct correlation…
Cardiology