Induction of regulatory T-cells to treat Type 1 Diabetes Mellitus

Gina Do Introduction: Type 1 diabetes mellitus (T1D) is an autoimmune disease where the host’s immune system attacks pancreatic β-cells, causing insufficient insulin production and, therefore, hyperglycemia1. Symptomatic progression of T1D often occurs during childhood and adolescence, with new diagnoses estimated at almost 90,000 children annually worldwide1. There is no…
Endocrinology Immunology

The Role of Estrogen in the Renin-Angiotensin Pathway in the Pathogenesis of Cardiovascular Disease in Postmenopausal Women

Neha Ali  Introduction. Cardiovascular disease is the leading cause of mortality in men and women in the USA. However, the risk of developing CV disease increases among women following menopause5. With increasing life expectancy, women may spend more than three decades in this postmenopausal state, increasing the likelihood of metabolic…
Cardiology Endocrinology

The Impact of Intrauterine Nutrition and Epigenetic Modifications on the Development of Obesity and Type II Diabetes

Ammad Khan Introduction.  Nutrition, especially early dietary exposures, plays a critical role in a person’s health throughout their life1.It has been substantiated that external factors can cause cell type-dependent epigenetic changes including those that are commonly attributed to obesity and diabetes2,9,10. Obesity, defined as a BMI greater than 30, has…
Endocrinology

The Role of the Gut Microbiome in Mediating Obesity

Connie Hsiao  Introduction.  Obesity is a condition characterized by excessive adipose tissue and increases an individual’s risk for health, social and mental issues. Obesity is a major issue in the United States, where more than one-third of Americans are clinically obese (BMI ≥ 30 kg/m2).1 Environmental and genetic factors both…
Endocrinology Microbiology

Mobilizing Regulatory T Cells Against Type I Diabetes

Robert Leonard Introduction: Type I diabetes (T1D) is a chronic autoimmune disease where self-reactive T cells damage insulin-producing pancreatic beta cells resulting in hyperglycemia1. The etiology is unclear but evidence suggests it arises from an environmental trigger with genetic predisposition1. Treatment of T1D, although advancing, still consists of insulin replacement…
Endocrinology Featured Abstracts Immunology

High Intensity Interval Training as Treatment for Type 2 Diabetes Mellitus

Alex Gustafson Introduction: Type 2 Diabetes Mellitus (T2D) is a chronic disease characterized by insulin resistance, systemic inflammation, and impaired GLUT-4 translocation1. T2D has become epidemic in the U.S. as 1/3 of the population is diabetic or pre-diabetic2. These Americans are susceptible to major hyperglycemic related consequences such as strokes,…
Endocrinology Featured Abstracts