The Role of Immunity in Maintaining the Muscle Satellite Cell Niche Necessary for Satellite Cell Function in Health and in Duchenne Muscular Dystrophy

Carolina Orsi Introduction Duchenne Muscular Dystrophy (DMD) is a genetic condition resulting from a mutation in dystrophin, which is an essential protein needed to anchor striated myofibrils to the extracellular matrix (ECM)1,3. With decreased structural stability, extensive damage results during myofibril contraction and induces vast immune and inflammatory responses within…
Featured Abstracts Immunology Inflammation Neuroscience

Overexpression of transcription factors Mafa and Pdx1 induces in-vivo transdifferentiation of pancreatic α cells to β-like insulin-producing cells

Nathan Sabin Introduction: Type 1 diabetes, or T1D, is a disease resulting from autoantibody mediated destruction of insulin-producing pancreatic β cells1-3. Daily insulin injections have been the gold standard for treatment since 1922, however, inadequate levels of acute glucose control in diabetic patients leads to a higher risk of medical complications including ketoacidosis, kidney…
Endocrinology Featured Abstracts

Using Pro-Insulin Peptide Immunotherapy to Elicit a Foxp3 T-regulatory Response and Suppress Autoimmunity in Type 1 Diabetes Mellitus

Laure Cundiff Introduction.  Type 1 diabetes (T1D) is an autoimmune disease characterized by T-cell destruction of host pancreatic insulin-producing beta cells, resulting in chronic hyperglycemia and long-term vascular complications.1,2  HLA-DQ-restricted CD4 T-cells are found in the pancreatic islets of these patients, causing IFN-γ mediated destruction of insulin producing cells.4,5,6  Further,…
Endocrinology Featured Abstracts Immunology Inflammation

Role of STAT5 in pathogenesis of Philadelphia chromosome positive Chronic Myelogenous Leukemia (CML)

Gonzalo Careaga Barja Introduction.  Chronic Myeloid Leukemia (CML) is type of blood cancer that affect the myeloid lineage of leukopoiesis. Most of the cases of CML have the Philadelphia chromosome which is a translocation between chromosome 9 and 22. This abnormal chromosome encodes for BCR-ABL fusion protein which has constitutive…
Cancer Featured Abstracts

The Role of Gamma-Secretase Modulators in Reducing ß-amyloid Plaque Formation in Patients with Alzheimer’s Disease

Courtney Welch  Introduction.  Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, and the risk increases with age so that by age 85 some studies suggest that ∼50% of individuals will have the disease1,2. The pathological hallmarks of AD include the presence of senile plaques and neurofibrillary tangles (NFT).  Senile…
Featured Abstracts Neuroscience