Category: Featured Abstracts

Triple Combination Therapy of CDK4/6 Inhibitors, Endocrine Therapy, and mTOR/PI3K Inhibitors to Treat Hormone Receptor-Positive Human Epidermal Growth Factor Receptor-2 Negative Breast Cancer with Acquired Resistance

June 22, 2023 Rebecca Waugh
Rebecca Waugh Background: In America breast cancer is the most frequently diagnosed malignancy in women2,5. Hormone receptor-positive human epidermal growth factor receptor-2 negative (HR+/HER2-) tumors categorize 65-70% of all cases and has one of the lowest survival rates1,2. Recent meta-analysis incorporate modulation CDK 4/6 inhibitors (CDKi) with endocrine therapy as…
Cancer Endocrinology Featured Abstracts

Cord Blood Lymphatic Endothelial Progenitor Cells Exposed to Preeclampsia in Utero Prime Individuals to Form an Abnormal Lymphatic System After Birth

June 22, 2023 Samantha Pozo Navarro
Samantha Pozo Navarro Background: Preeclampsia is a complex, new-onset hypertensive disorder that affects 3-8% of all pregnancies worldwide.1 In this case, hypertension is defined when the mother’s systolic blood pressure is greater than or equal to 140 mmHg and/or her diastolic blood pressure is greater than or equal to 90…
Development Featured Abstracts Reproduction

Balance of Activity of D1Rs and D2Rs on Medium Spiny Neurons in the Striatum Can Explain Persistence of Alcohol Seeking Behavior in Alcohol Use Disorder

June 22, 2023 Madelyn Pegues
Madelyn Pegues Background: Alcohol use disorder is a significant contributor to preventable death and economic burden both in the United States and globally.1 There is a large treatment gap due to the stigma surrounding mental health disorders and even individuals that receive treatment continue to have high relapse rates.2 Understanding…
Featured Abstracts Neuroscience

Investigating the Roles of the Innate and Adaptive Immune Systems in Alzheimer’s Pathogenesis

June 22, 2023 Oliver Zhou
Oliver Zhou Background:  Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by buildup of amyloid-β plaques, neurofibrillary tau tangles, and neuroinflammation that leads to progressive memory loss and cognitive decline.1 It is the most common neurodegenerative disorder and contributes to an estimated 60-80% of dementia cases worldwide.1 It is…
Featured Abstracts Immunology Neuroscience

The Mechanisms and Effectiveness of Interferon Therapeutics for the Treatment of Hepatitis B Virus

June 22, 2023 Nailah Blair
Nailah Blair Background: Hepatitis B is a potentially chronic virus of the liver causing inflammation, fibrosis, cirrhosis, and even hepatocellular carcinoma if unsuccessfully treated. 1,2. There are currently two families of medications widely being used to treat chronic HBV: Nucleoside/tide analogs, which inhibit the production of daughter virions, and interferons…
Featured Abstracts Microbiology

Mutations of the NOTCH1 Signaling Pathway Constitute Congenital Cardiac Anomalies in patients with Tetralogy of Fallot

June 22, 2023 My Lai
My Lai Background: Tetralogy of Fallot is the one of the most common cyanotic congenital heart diseases, affecting 3 out of 10,000 infants yearly.1 Tetralogy of Fallot (TOF) features 4 significant hallmarks, including ventricular septal defect (VSD), aorta overriding VSD, pulmonary stenosis, and right ventricular hypertrophy. 2,3 Current successful treatment…
Cardiology Development Featured Abstracts

The Mechanism and Treatment of Pediatric Low-Grade Glioma and Optic Glioma in children with Neurofibromatosis Type 1

June 22, 2023 Talia Meidan
Talia Meidan Background: Neurofibromatosis Type 1 (NF1) is an autosomal dominant genodermatotic and tumor predisposition disorder characterized by a mutation in the NF1 gene, a regulator of the RAS/MAPK pathway.1,2 Patients with NF1 are predisposed to CNS tumors, with 15-20% developing gliomas. Moreover, approximately 15% of children with NF1 develop…
Cancer Featured Abstracts