Category: Featured Abstracts

Utilization of Targeted CRISPER / CAS9 Next-Generation Sequencing to Predict Virulence of Legionnaires’ Disease

June 21, 2023 Joshua Carter
Joshua Carter Background: Legionnaires’ disease (LD) is characterized as a pneumonia secondary to an infection by the bacterium Legionella pneumophila (Lp).1 Identification of Legionella first occurred after an outbreak of an atypical pneumonia at the 1976 American Legion Convention in Philadelphia, PA – with the offending Gram-negative bacillus, Lp, being…
Featured Abstracts Microbiology

In Pancreatic Islets from Type 2 Diabetes Patients, the Dampened Circadian Oscillators Lead to Reduced Insulin and Glucagon Exocytosis

June 21, 2023 Brock Jones
Brock Jones Background: Type 2 Diabetes Mellitus (T2D) is a disease resulting from decreased insulin sensitivity within the body mainly due to lifestyle choices related to diet and exercise.1 T2D seems to mainly stem from lifestyle, with a high caloric and high glycemic diet with insufficient exercise increasing the rate…
Circadian Rhythms Endocrinology Featured Abstracts

Osteoarthritis Treatment: The Role of the WNT and BMP Pathways in Chondrogenic Differentiation of Mesenchymal Stem Cells

June 21, 2023 Jerry Liu
Jerry Liu Background: Osteoarthritis is the most prevalent chronic joint disease3, and is a leading cause of disability in older adults.1 OA involves the entire joint and works by causing articular cartilage loss.3 Pain, along with loss of range of motion, are both major symptoms of osteoarthritis.1,2 First-line treatment involves…
Featured Abstracts Orthopedics Stem Cells

Multi-Organ System Signaling Converges on Resident Cardiac Macrophage Kruppel-Like Factor 4 to Preserve Cardiac Function During Heart Failure

June 21, 2023 Jacob Kuempel
Jacob Kuempel Background: Heart failure affects over 23 million people globally and is the leading cause of mortality worldwide.1 Heart failure with reduced ejection fraction (HFrEF) has the worst prognosis of the 3 clinical subtypes of heart failure and accounts for ~50% of all heart failure cases.1 Increasing global incidence…
Cardiology Featured Abstracts

The Combination of Radiofrequency Ablation with Chemotherapy May Improve Hepatocellular Carcinoma Patient Outcomes

June 21, 2023 Jacob Abell
Jacob Abell Background: Hepatocellular carcinoma (HCC) is the 6th most common cause of cancer worldwide with 700,000 new cases each year and the average survival rate is 19.6% in the United States.¹ The most common primary malignancy of the liver, HCC significant risk factors include chronic alcohol consumption, viral infections,…
Cancer Featured Abstracts Hepatology

Beneficial and Detrimental Effects of the Adaptive Immune System Post-Traumatic Brain Injury

June 21, 2023 Iris Vallavanatt
Iris Vallavanatt Background: Traumatic brain injury (TBI) is mechanical damage to brain parenchyma that causes neuronal death, axonal damage, ischemia, and hemorrhage and can result in secondary injury. This secondary injury results from chronic activation of the inflammatory immune cascade necessary for debris clearance and regeneration and can persist for…
Featured Abstracts Neuroscience