Featured Abstracts – Page 8 – Proceedings of the Texas A&M Medical Student Grand Rounds

Protein C and its Interaction with YB-1 as a Potential Therapeutic in Diabetic Cardiomyopathy Caused by Hyperglycemia Induced Oxidative Stress

June 21, 2023 Julia Hwang

Julia Hwang Background: Diabetes mellitus is the fifth most common cause of death in the world.2 Type 1 Diabetes is an autoimmune condition where pancreatic beta cells are destroyed, leaving the body unable to produce insulin.1 Diabetics are 2-3 times more likely to develop cardiovascular diseases, and 80% of diabetic…

Endocrinology Featured Abstracts

Probiotic Effects on Immunity, Lymphatics in Atopic Dermatitis

June 21, 2023 Holly Novak

Holly Novak Background: Atopic Dermatitis (AD) is a complex skin condition caused by combination of genetics, immunity, and environmental factors that weaken the skin barrier.1 It affects 1 in 10 people.1 AD typically begins in early childhood for about 80% of those affected. Patients with AD commonly have a filaggrin…

Targeting the PI3K/AKT/mTOR Pathway to Overcome Resistance to Endocrine Therapy and CDK4/6 Inhibitors in Estrogen Receptor-Positive Metastatic Breast Cancer

June 21, 2023 Holly Hodge

Holly Hodge Background: Breast cancer has continued to increase in incidence and now accounts for 31% of all cancer diagnoses1. Breast cancer is classified into subtypes based on the presence of hormone receptors and the human epidermal growth factor receptor 2 protein1. Hormone receptor-positive breast cancer is the most common…

Cancer Endocrinology Featured Abstracts

Intranasal Administration of Stem Cell-Derived Extracellular Vesicles inhibits the Neuroinflammatory Cascade After Traumatic Brain Injury

June 21, 2023 Minh-Nguyet Hoang

Minh-Nguyet Hoang Background: Traumatic brain injury (TBI) is a multifactorial condition caused by an external mechanical force that can lead to various neurological impairments, including physical, psychological, and cognitive functions1,3,4. TBIs represent the third most common cause of mortality worldwide, with an increased risk in the elderly, athletes, and low…

Featured Abstracts Inflammation Neuroscience

The Use of the Nogo Receptor as a Target for Future Therapeutics in Spinal Cord Injury

June 21, 2023 Hoang Dao

Hoang Dao Background: Spinal cord injury is a devastating neurological condition that follows from significant trauma with symptoms such as paralysis, spasticity, and cardiovascular, bowel and sexual dysfunction.1 Spinal cord injury (SCI) affects between 250,000 and 500,000 individuals every year with these people being two to five times more likely…

Featured Abstracts Neuroscience

p53 and CHEK2 as Modulators for CDK4/6 Inhibitor Response in BRAF/MEK Inhibitor Resistant BRAFV600 Mutant Melanoma

June 21, 2023 Peyton Harris

Peyton Harris Background: Melanoma, which is the 19th most common cancer diagnosed throughout the world, is a malignant tumor arising from melanocytes.1, 4 While melanoma makes up only 3-5% of skin cancers, 65% of skin cancer related deaths are a result of melanoma.1, 4 Treatment options include surgical excision as…

Cancer Featured Abstracts

Nanobody Therapy Neutralizing Common Domains in the SARS – COVID-19 Virus and its Variants

June 21, 2023 Hannah Clayton

Hannah Clayton Background: The Severe Acute Respiratory Syndrome Coronavirus – 2 (SARS-CoV-2), also known as covid-19, caused the global pandemic that began in 2019. Covid-19 is transmitted via respiratory droplets and attacks ciliated cells and type II pneumocytes in lung tissue. It has had a case fatality rate of approximately…

Featured Abstracts Microbiology

Addressing the TLR4 Pathway for the Prevention of Ulcerative Colitis and Colitis Associated Cancers

June 21, 2023 Hamza Masood

Hamza Masood Background: Ulcerative Colitis (UC) is a form of inflammatory bowel diseases (IBD) that causes mucosal inflammation of the entire colon.1 This leads to decrease in quality of life due to the remitting and relapsing nature of the disease with increased risk of infection, anxiety, depression, and colon cancer.…

Cancer Featured Abstracts

Upregulated miRNA-34a Culminates in Decreased TREM2 Expression Influencing the Microglial Response in Alzheimer Disease

June 20, 2023 Tiffany Gunnels

Tiffany Gunnels Background: Alzheimer disease (AD) is a neurodegenerative disease impacting the lives of more than 50 million people worldwide, and this number is expected to increase significantly by 2050.1 Domains affected are typically memory, language, spatial cognition, and executive function.2 The pathogenesis of AD is thought to progress due…

Featured Abstracts Neuroscience

The Role of Dysfunctional Autophagy on Amyloid Plaque Formation in Alzheimer’s Disease

June 20, 2023 Sumeen Gill

Sumeen Gill Background: Alzheimer’s disease (AD) is a complex multifactorial neurodegenerative disorder characterized by progressive memory loss and multiple other cognitive changes. As per a 2016 report, over 46.8 million individuals suffer from AD worldwide, and cases are projected to reach more than 131 million by 2050 [1]. Despite its…

Featured Abstracts Neuroscience