Category: Featured Abstracts

The Role of Vacuolating Cytotoxin A (VacA) Allelic Variations in Helicobacter pylori Infection Related Peptic Ulcer Disease

June 20, 2023 Genichiro Fujioka
Genichiro Fujioka Background: Peptic ulcer disease (PUD) is a gastrointestinal disease that involves lesions of the stomach or duodenum that extend to at least the submucosal layer.1 Untreated PUD can lead to many serious and life-threatening complications such as acute upper GI bleeding, perforation, and gastric outlet obstruction.1 One of…
Featured Abstracts Immunology

Investigating the Role of IFN-γ in the Association Between Maternal Immune Activation and Autism Spectrum Disorder

June 20, 2023 Erin Mikeska
Erin Mikeska Background: Conservative reports estimate Autism Spectrum Disorder (ASD) to affect 1 in 132 individuals which translates to around 52 million people globally. 1 ASD is an umbrella term that by definition of the DSM-V includes symptoms of social impairment and repetitive behaviors.1,2,3 The wide range of possible symptoms,…
Featured Abstracts Immunology Neuroscience

Targeting Deubiquitination of Androgen Receptor Restores Sensitivity of Castration-Resistant Prostate Cancer to Enzalutamide

June 20, 2023 Emily Hong
Emily Hong Background: Castration-resistant prostate cancer (CRPC) is late-stage prostate cancer.8 Prostate cancer, the second-most common malignancy for men, needs androgens for progression and growth at early stages.7 Despite 80-90% therapeutic efficiency of androgen deprivation therapy (ADT), 10-20% of prostate cancer cases become resistant to ADT and progress to CRPC…
Cancer Featured Abstracts

Adoptive T cell Therapies Targeting Cancer/Testis Specific Antigens in Solid Tumors

June 20, 2023 Emily Ensley
Emily Ensley Background: Solid tumors are abnormal masses that do not contain fluid.1 Three major categories of solid tumors include melanoma, carcinoma, and sarcoma, and prognosis depends primarily on the tumor type, its location, and timing of diagnosis. Many solid tumors are resistant to current therapeutic options.2-6 Cancer immunotherapies such…
Cancer Featured Abstracts Immunology

The Use of the Immunotherapy Drugs, Pembrolizumab, a PD-1 Inhibitor, and Tisotumab vedotin, an Antibody Drug Conjugate Against Tissue Factor, in the Treatment of Recurrent or Metastatic Cervical Cancer

June 20, 2023 Emilie Sandfeld
Emilie Sandfeld Background: The human papillomavirus (HPV), a non-enveloped double stranded DNA virus is the causative agent of many illnesses from genital warts to cervical cancer.1 Cervical cancer, most commonly caused by HPV strains 16 and 18, is currently the 4th most common form of cancer in women throughout the…
Cancer Featured Abstracts Immunology

Selective Inhibition of C1r Serine Protease in the Classical Complement System by BBK32 Mediates Lyme Disease

June 20, 2023 Danielle Pischulla
Danielle Pischulla Background: Lyme Disease is a multisystem illness with the potential to affect the skin, joints, heart, and nervous system and accounts for roughly 90% of all vector-borne diseases in the United States.1,2 The spirochete bacteria, Borrelia burgdorferi, causes Lyme Disease and is transmitted by the bite of the…
Featured Abstracts Microbiology

Multiple Sclerosis and Epstein Barr Virus: Exploring Molecular Mimicry Between EBNA1 and GlialCAM and its Potential Contribution to Multiple Sclerosis

June 20, 2023 Christina Garcia
Christina Garcia Background: Multiple Sclerosis (MS) is the most common neurodegenerative disease to affect young adults, affecting females more commonly than males.1 MS is characterized by perivascular inflammatory lesions which lead to oligodendrocyte damage and demyelinating plaques.1 There is no cure for MS and the available treatments are limited and…
Featured Abstracts Microbiology Neuroscience

Ambroxol-Mediated Rescue of Dysfunctional Glucocerebrosidase as a Neuroprotective Treatment for Parkinson’s Disease

June 20, 2023 Dylan Noble
Dylan Noble Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects over 6 million individuals worldwide.1 A diagnosis of PD is made through a combination of history taking, neurological exam, and response to dopamine therapy.3 At the cellular level, PD is characterized by the loss of dopaminergic neurons…
Featured Abstracts Neuroscience