Category: Immunology

The Role of Vacuolating Cytotoxin A (VacA) Allelic Variations in Helicobacter pylori Infection Related Peptic Ulcer Disease

June 20, 2023 Genichiro Fujioka
Genichiro Fujioka Background: Peptic ulcer disease (PUD) is a gastrointestinal disease that involves lesions of the stomach or duodenum that extend to at least the submucosal layer.1 Untreated PUD can lead to many serious and life-threatening complications such as acute upper GI bleeding, perforation, and gastric outlet obstruction.1 One of…
Featured Abstracts Immunology

Investigating the Role of IFN-γ in the Association Between Maternal Immune Activation and Autism Spectrum Disorder

June 20, 2023 Erin Mikeska
Erin Mikeska Background: Conservative reports estimate Autism Spectrum Disorder (ASD) to affect 1 in 132 individuals which translates to around 52 million people globally. 1 ASD is an umbrella term that by definition of the DSM-V includes symptoms of social impairment and repetitive behaviors.1,2,3 The wide range of possible symptoms,…
Featured Abstracts Immunology Neuroscience

Adoptive T cell Therapies Targeting Cancer/Testis Specific Antigens in Solid Tumors

June 20, 2023 Emily Ensley
Emily Ensley Background: Solid tumors are abnormal masses that do not contain fluid.1 Three major categories of solid tumors include melanoma, carcinoma, and sarcoma, and prognosis depends primarily on the tumor type, its location, and timing of diagnosis. Many solid tumors are resistant to current therapeutic options.2-6 Cancer immunotherapies such…
Cancer Featured Abstracts Immunology

The Use of the Immunotherapy Drugs, Pembrolizumab, a PD-1 Inhibitor, and Tisotumab vedotin, an Antibody Drug Conjugate Against Tissue Factor, in the Treatment of Recurrent or Metastatic Cervical Cancer

June 20, 2023 Emilie Sandfeld
Emilie Sandfeld Background: The human papillomavirus (HPV), a non-enveloped double stranded DNA virus is the causative agent of many illnesses from genital warts to cervical cancer.1 Cervical cancer, most commonly caused by HPV strains 16 and 18, is currently the 4th most common form of cancer in women throughout the…
Cancer Featured Abstracts Immunology

T-Cell Imbalance and Inflammatory Cytokines as Potential Drug Targets for the Treatment of Myasthenia Gravis

June 20, 2023 Alec J Monhollen
Alec J Monhollen Background: Myasthenia gravis is an autoimmune disorder against post-synaptic proteins in the neuromuscular junction, including the acetylcholine receptor and muscle-specific kinase.1,2  Symptoms can include general muscle weakness, ptosis, diplopia, and dysarthria.1,3 The current standard treatments are acetylcholinesterase inhibitors which function to increase the amount of acetylcholine in…
Featured Abstracts Immunology Inflammation Neuroscience

Mesenchymal Stem Cell Exosomes Provide Function-Saving Immunomodulatory Effects in Myocardial Infarction Through Macrophage Polarization

June 20, 2023 Christopher Story
Christopher Story Background: A Myocardial Infarction (MI) is a life-threatening cardiac event that afflicts over 800,000 individuals every year in the United States alone resulting in either fatality or a significant reduction in heart function.1 MI’s occur when one or more coronary arteries become occluded leading to a lack of…
Cardiology Immunology

The Emerging Role of Chimeric Antigen Receptor Therapies in the Treatment of Autoimmune Disorders

June 8, 2023 Scarlett Bloodworth
Scarlett Bloodworth   Background: Newly engineered chimeric antigen receptor T lymphocyte therapies have been successfully used in certain cancers, including leukemias and non-Hodgkin lymphoma.1 These CAR-T therapies are used to eradicate over-proliferating cells by programming cytotoxic T lymphocytes to induce apoptosis upon binding the B lymphocyte specific cell marker CD19.2…
Cancer Featured Abstracts Immunology

CD40 Agonists Reprogram Tumor Associated Macrophages to Reduce Immunosuppression in Pancreatic Ductal Adenocarcinoma

June 8, 2023 Baylee J. O’Brien
Baylee J. O’Brien  Background: Pancreatic ductal adenocarcinoma (PDAC) is cancer of the ductal cells of the pancreas and is projected to become the second leading cause of cancer related deaths by 20301. The low survival rate is largely due to the fibrotic stroma of the PDAC tumor microenvironment with infiltration…
Cancer Featured Abstracts Immunology

The Therapeutic Effects of Exosomes Derived From Human Adipose Tissue-Derived Mesenchymal Stem Cells in Alleviating Atopic Dermatitis By Reducing Type 2 Helper T Cell Induction

June 6, 2023 Anna (Seo Won) Cho
Anna (Seo Won) Cho Background: Atopic dermatitis (AD) is an inflammatory skin condition characterized by pruritus and cutaneous lesions with a 10% lifetime prevalence.1 Th1 and Th2 cells are upregulated in AD in which Th1 cells activate delayed hypersensitivity reactions while Th2 cells induce B cells to produce IgE antibody…
Featured Abstracts Immunology Inflammation