Category: Inflammation

The Role of NF-kB in Vascular Inflammation in Pre-eclampsia Through Down Regulation of eNOS at the Post-transcriptional Level via miRNA Expression

July 7, 2020 Nastassia Pham
Nastassia Pham Introduction. Pre-eclampsia is a pregnancy induced hypertensive disorder characterized by systolic blood pressure greater than 140 mmHg and diastolic blood pressure greater than 90 mmHg that usually presents after 20 weeks of gestation1,2. The pathology begins with malfunction during trophoblast invasion, resulting in reduced uteroplacental perfusion1. This stresses…
Cardiology Inflammation

The Role of H. pylori in the Progression of Gastric Cancer Through Activation of the JAK/STAT Pathway and Sequential Inflammatory Response Elements

July 7, 2020 Sanjana Nayak
Sanjana Nayak Introduction. Gastric cancer is one of the leading causes of cancer-related death in the world, with the rate of incidence still high in East Asia1. H. pylori infection is the main risk factor, with the likelihood for infection increasing with greater age, higher BMI, and male sex2,3,4. H.…
Cancer Inflammation Microbiology

The Role of Mast Cell-Mediated Inflammation on IBS-Induced Abdominal Pain

July 7, 2020 Pavia Ann Muringathuparambil
Pavia Ann Muringathuparambil Introduction: IBS is a gastrointestinal disease triggered by many factors. Symptoms vary greatly between patients, but abdominal pain and bloating are most common. While a specific cause has yet to be identified, many factors including gene mutations1,2, gut microbiome imbalances3, and mast cell hyperplasia4 are being investigated…
Inflammation Microbiology

Use of Synovium-Derived Mesenchymal Stem Cells to Form Scaffold-Free Tissue Engineered Construct to Promote Repair of Knee Chondral Lesions to Prevent Development of Osteoarthritis

July 6, 2020 Victoria Hamilton
Victoria Hamilton  Introduction: Osteoarthritis (OA) is the most common joint disorder in the world (global prevalence 3.8%) and significantly contributes to disability globally.1–3 OA of the knee (KOA) has the highest incidence in the body, with a lifetime risk of approximately 45%.3 Mesenchymal stem cells (MSCs) are heterogenous stem cells…
Featured Abstracts Inflammation Orthopedics Stem Cells

The Role of Vitamin D in Reducing Campylobacter jejuni-Induced Colonic Epithelial Apoptosis and Inflammation

July 6, 2020 Christian Encarnacion
Christian Encarnacion  Introduction. Human Campylobacter jejuni infections comprises most bacterial gastrointestinal illnesses worldwide1,2. C. jejuni transmissions are primarily foodborne and sequelae of C. jejuni campylobacteriosis also result in autoimmune diseases such as Guillain-Barre Syndrome1,2. Studies have shown that C. jejuni promotes proinflammatory cytokines that result in debilitating changes to the…
Inflammation Microbiology

Green Tea Extract Dietary Therapy Protection Against Dysbiotic Microbiota Induced Metabolic Endotoxemia through Increased Intestinal Barrier Function, Decreased Endotoxin Translocation, and Decreased Chronic Inflammation

July 3, 2020 Sreeya Cherlo
Sreeya Cherlo Introduction. Dysbiosis, an imbalance in the gut microbial community, and consequent lymphatic inflammation are associated with the development of a multitude of diseases.1 Metabolic Endotoxemia is caused by the presence of endotoxins in the blood which are derived from gram-negative bacteria included in dysbiotic gut microbiota.1 The translocation…
Inflammation Microbiology