Category: Inflammation

Therapeutic Effects of Mdivi-1 in Sepsis Associated Encephalopathy Through Attenuation of Oxidative Stress

July 23, 2018 Charina Benavidez
Charina Benavidez Introduction. Sepsis associated encephalopathy (SAE) is an inflammatory-mediated complication that arises as a secondary effect of an infection that originated in another part of the body1. It causes a generalized cerebral dysfunction without any actual invasion or infection of the central nervous system1,2. SAE is the most common…
Inflammation Neuroscience

Targeting Pax4 for α- to β-cell Transdifferentiation: a Promising Therapy for Diabetes Mellitus Type 1

July 23, 2018 Victor H. Rodríguez
Victor H. Rodríguez Introduction. Type 1 diabetes mellitus (T1DM) is an autoimmune disease causing chronic inflammation of the pancreatic islets of Langerhans affecting β cells and insulin production and yields hyperglycemic states in individuals1. T1DM affects U.S. 3 million people2. Untreated individuals develop retinopathy, kidney disease, cardiovascular disease, and neuropathy3.…
Endocrinology Inflammation

The Protective Role of Interleukin 35 on Regulatory T Cells and Angiogenic Factors to Prevent Further Progression of Rheumatoid Arthritis

July 23, 2018 Ryan Surujdin
Ryan Surujdin Introduction. Rheumatoid Arthritis is an autoimmune disease that causes inflammation and progressive destruction of the joints. The disease affects about 1% of the population at any age, but occurs more often in women. It can be caused by numerous factors such as mutations in MHC class II loci,…
Immunology Inflammation

The Role of Mitochondria in Promoting Dysfunctional Neutrophil Extracellular Traps in Systemic Lupus Erythematosus Pathogenesis

July 23, 2018 Kirtan Patel
Kirtan Patel Introduction. Systemic Lupus Erythematosis (SLE) is a chronic autoimmune inflammatory disorder in which anti-nuclear antibodies are thought to cause multi-organ damage2,3,7. Studies have found that plasmacytoid dendritic cells (pDC) are at the center of SLE pathogenesis as they are the prime producers of Interferon-1 (IFN-1)1,5,6. It has long…
Featured Abstracts Immunology Inflammation

The Role of omega-3 polyunsaturated fatty acids (N-3 PUFAs) on IL-6 and TH17 cell differentiation in delaying the progression of multiple sclerosis (MS)

July 20, 2018 Kyle S. Johnson
Kyle S. Johnson Introduction: MS is a chronic inflammatory autoimmune disease involving myelin-specific autoreactive T cells that cause episodic progressive demyelination of CNS neuronal axons1,2. Release of IL-17 by TH17 cells is heavily implicated in the pathogenesis of MS via TGF-B and IL-6 stimulated production of the transcription factor RORyT,…
Inflammation Neuroscience

Immunomodulatory Effects of Mesenchymal Stem Cells on the Aberrant T-cell Response in Crohn’s Disease

July 20, 2018 Samuel Lyons
Samuel Lyons Introduction: Crohn’s disease (CD) is a chronic inflammatory disease of the bowel resulting from dysregulated immune responses toward microbial antigens like muramyl-dipeptide (MDP), a frequent member of healthy intestinal flora1. Studies have demonstrated a connection between this immune response and unbalanced populations of Treg, Th1, and Th17 cells…
Immunology Inflammation Stem Cells

IL-6 In Cytokine Release Syndrome during CAR-T Cell Therapy

July 19, 2018 Tan Luu
Tan Luu Introduction. A new promising immunotherapy treatment utilizing Chimeric Antigen Receptors (CAR) on genetically modified host T cells has a major auto immune side effect known as Cytokine Release Syndrome (CRS), a non-antigen specific toxicity that occurs as a result of high-level immune reaction that clinically manifests when large…
Immunology Inflammation

The Controversial Theories of the Unfolded Protein Response and Autophagy as Underlying Mechanisms for the Increase in the Proinflammatory Cytokine IL-23 in Ankylosing Spondylitis.

July 19, 2018 Brett Johnson
Brett Johnson Introduction: Ankylosing Spondylitis (AS), the most severe form of Spondyloarthritis (SpA), causes chronic inflammation most commonly found in the vertebral and sacroiliac joints. AS can be a debilitating disease causing severe back pain, stiffness and new bone growth1. Although AS can affect either sex, any race, and all…
Featured Abstracts Immunology Inflammation