Circadian Rhythm Impact on Entry, Progression, Secondary & Long-term Effects of SARS-CoV-2

Revanth Vadlamudi Introduction. This study investigates the potential influence of circadian rhythms and clock genes on the infection and pathogenesis of SARS-CoV-2 to preface future targets for prophylaxis, chronotherapeutics during infection, and long-term secondary illness. SARS-CoV-2 is a pneumotropic RNA beta-coronavirus of zoonotic origin; human transmission occurs primarily via respiratory…
Circadian Rhythms Microbiology

Use of Rifabutin-Based Triple Therapy (RHB-105) to Combat Antibiotic Resistance in Helicobacter pylori Infection Treatment

Sayali Shelke Introduction. Helicobacter pylori is a gram-negative bacterial infection that affects 50% of the global human population and is a topic of interest in several fields of medicine due to its severe sequalae, such as peptic ulcer, gastritis, and gastric cancer.2 H. pylori possesses different virulence factors, such as…
Gastroenterology Microbiology

HPV Infection Induces Secondary Mutations Resulting in Host Immune Defense Evasion and Oropharyngeal Cancer Abstract

Masen Ragsdale Introduction. In recent years, there has been a rise in the incidences of human papilloma virus-positive oropharyngeal cancer, especially in men.1,2 A persistent HPV 16 infection is responsible for 70% or more of oropharyngeal squamous cell carcinomas (OPSCC).1,2 Risk factors for developing this type of cancer include risky…
Cancer Microbiology

SARS-CoV-2 Nsp1 Mediated Shutdown of Host mRNA Translation

Hunter Olsen Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for coronavirus disease 2019 (COVID-19)1. Disease presentation can range from asymptomatic to severe, with serious cases resulting in acute respiratory distress syndrome or multiorgan failure2. SARS-CoV-2 has a positive sense, single-stranded, RNA genome3. Upon infection, the…
Microbiology