The Mechanisms and Effectiveness of Interferon Therapeutics for the Treatment of Hepatitis B Virus

Nailah Blair Background: Hepatitis B is a potentially chronic virus of the liver causing inflammation, fibrosis, cirrhosis, and even hepatocellular carcinoma if unsuccessfully treated. 1,2. There are currently two families of medications widely being used to treat chronic HBV: Nucleoside/tide analogs, which inhibit the production of daughter virions, and interferons…
Featured Abstracts Microbiology

Use of Specific Heparan Sulfate Targets as Therapeutic Treatment Against Human Papillomavirus Infection

Kadambari Suri Background: Though prophylactic vaccines exist, ~80% of people (both men and women) will be infected by human papillomavirus (HPV) during their lifetime. While outcomes of HPV infection vary significantly among individuals, HPV is responsible for about one-third of all cancers – including the majority of cases of cervical…
Featured Abstracts Microbiology

The Role of the Gut Microbiome in the Reduction of Behavioral Symptoms in Children with Autism Spectrum Disorder (ASD)

Taylor Newman Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication, repetitive behavioral patterns, highly restricted interests and/or sensory behaviors early in life. 1,3 Children with ASD are 3.5 times more likely to suffer from GI disorders, such as diarrhea and constipation, than…
Featured Abstracts Microbiology Neuroscience Psychiatry

Several Important Virulence Mechanisms Enable Yersinia pestis to Establish Deadly Infections Requiring Prompt Medical Intervention

Matthew Landry Background: Plague is one of the most historically and culturally important diseases ever to impact humankind. Yersinia pestis, the causative agent of plague, has led to no less than three pandemics within the last 1500 years, and continues to be medically relevant causing over 26,000 cases of illness…
Featured Abstracts Microbiology

Utilization of Targeted CRISPER / CAS9 Next-Generation Sequencing to Predict Virulence of Legionnaires’ Disease

Joshua Carter Background: Legionnaires’ disease (LD) is characterized as a pneumonia secondary to an infection by the bacterium Legionella pneumophila (Lp).1 Identification of Legionella first occurred after an outbreak of an atypical pneumonia at the 1976 American Legion Convention in Philadelphia, PA – with the offending Gram-negative bacillus, Lp, being…
Featured Abstracts Microbiology

Selective Inhibition of C1r Serine Protease in the Classical Complement System by BBK32 Mediates Lyme Disease

Danielle Pischulla Background: Lyme Disease is a multisystem illness with the potential to affect the skin, joints, heart, and nervous system and accounts for roughly 90% of all vector-borne diseases in the United States.1,2 The spirochete bacteria, Borrelia burgdorferi, causes Lyme Disease and is transmitted by the bite of the…
Featured Abstracts Microbiology

Multiple Sclerosis and Epstein Barr Virus: Exploring Molecular Mimicry Between EBNA1 and GlialCAM and its Potential Contribution to Multiple Sclerosis

Christina Garcia Background: Multiple Sclerosis (MS) is the most common neurodegenerative disease to affect young adults, affecting females more commonly than males.1 MS is characterized by perivascular inflammatory lesions which lead to oligodendrocyte damage and demyelinating plaques.1 There is no cure for MS and the available treatments are limited and…
Featured Abstracts Microbiology Neuroscience