Category: Neuroscience

Inhibition of GSK-3-beta as a Therapeutic Option to Modulate Oxidative Stress via the WNT/beta-Catenin Pathway in Parkinson’s Disease

August 3, 2021 Jennifer Oruebor
Jennifer Oruebor  Introduction. Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by motor symptoms including tremor, bradykinesia, and postural imbalance. 1 PD pathology includes loss of dopaminergic neurons in the substantia nigra pars compacta and the deposition of alpha-synuclein protein aggregates (Lewy bodies).1 The loss of dopaminergic neurons in the…
Neuroscience

Allosteric Modulation of Metabotropic Glutamate Receptors as a Therapeutic Mechanism for Schizophrenia

August 3, 2021 Tran Nguyen
Tran Nguyen Introduction. Schizophrenia is a mental disorder with positive symptoms, such as delusions and hallucinations, and negative symptoms, such as flat affect and social isolation, compromising the core diagnostic criteria.1 Schizophrenia typically develops in early adulthood; it is rare before 16 years of age.1 The mental disorder currently affects…
Neuroscience Psychiatry

The Role of the NLRP3 Inflammasome in Alzheimer’s Disease Pathophysiology and as a Novel Therapeutic Target

August 2, 2021 Karthik Mouli
Karthik Mouli Introduction: Alzheimer’s Disease is a neurodegenerative disease that is the leading cause of dementia in the United States1. Alzheimer’s Disease is classically associated with the extracellular accumulation of amyloid-β plaques and hyperphosphorylated tau neurofibrillary tangles, yet a growing body of evidence points toward neuroinflammation – specifically chronic microgliosis…
Featured Abstracts Neuroscience

Chronic Traumatic Encephalopathy (CTE): The Football Disease. A Look into the Potential Diagnostics and Therapy for Focal Tau Hyperphosphorylation in Cortical Tissue.

August 2, 2021 Matthew G. Mitchell
Matthew G. Mitchell Introduction. Known for decades as “dementia pugilistica” or “punch-drunk syndrome” affecting boxers, Chronic Traumatic Encephalopathy (CTE) has been identified as a subset of traumatic brain injury resulting from exposure to repetitive force also prevalent in American football players and veterans.1 CTE clinically presents as progressively worsening mood…
Neuroscience

Alpha-Synuclein Propagates in a Prion-Like Fashion from the Gut to the Brain Inducing Parkinson’s Disease Pathology

August 2, 2021 Jessica Madry
Jessica Madry Introduction. On the global scale there is a prevalence of 100-300/100,000 people with Parkinson’s Disease (PD) and it is expected to double by 2030 due to the progressive aging of the world population1. Parkinson’s Disease is a multi-systemic neurodegenerative disease characterized by the degeneration of dopaminergic neurons in…
Neuroscience

Downregulation of the Melatonin Receptor MT1 on the Neuronal Outer Mitochondrial Membrane (OMM) Is A Key Determinant of the Initial Onset and Pathogenesis of Huntington’s Disease

August 2, 2021 Kendahl Lyle
Kendahl Lyle Introduction. Huntington’s disease is an autosomal dominant disease due to a CAG trinucleotide repeat on chromosome 4 and the greater number of repeats corresponds to an earlier onset of symptoms.1 Huntington’s disease has a prevalence of 10.6-13.7 per 100,000 in western populations, and females are shown to have…
Neuroscience

Promoting Brain Repair After Traumatic Brain Injury through IL-6 Trans-Signaling Dependent Microglial Repopulation

July 30, 2021 Marita John
Marita John  Introduction: Traumatic brain injury (TBI) is one of the major causes of morbidity and mortality worldwide.1 The hallmarks of TBI include cognitive dysfunction and activated microglia, but it is unclear whether activated microglia are harmful or beneficial. Recent studies have investigated whether manipulating the activation of microglia or…
Neuroscience