Neuroscience – Page 3 – Proceedings of the Texas A&M Medical Student Grand Rounds

Effects of Blocking PTEN in Central Nervous System Axons on Axon Regeneration and Functional Outcomes Following Spinal Cord Injury

June 22, 2023 Tarun Sontam

Tarun Sontam Background: Spinal cord injury (SCI) is a form of traumatic and/or degenerative damage to the spinal cord that dramatically impacts quality of life and can ultimately lead to severe functional effects such as loss of mobility and/or sensation. Around the world, there are about 930,000 new cases of…

Featured Abstracts Neuroscience

Biological Therapies for Spinal Muscular Atrophy Along the Agrin/MuSK/Lrp4/DOK7 Pathway at the Neuromuscular Junction

June 22, 2023 Sangeetha Narayan

Sangeetha Narayan Background: Spinal Muscular Atrophy is a genetic disorder that results from the mutation or deletion of the SMN1 gene on chromosome 5 1.2.3.4. This disease affects infants as young as six months 2,3. This deletion leads to the loss of the protein survival motor neuron (SMN) which ultimately…

Featured Abstracts Neuroscience

Investigating the Underlying Mechanisms between Aβ Plaque Accumulation and Neuronal Dysfunction in Alzheimer’s Disease Progression

June 22, 2023 Sahil Sinha

Sahil Sinha Background. Alzheimer’s disease (AD) is a neurodegenerative disorder that results in memory loss, cognitive decline and changes in behavior and personality, and is the most common form of dementia for individuals over the age of 65 years old.6 There is no cure for Alzheimer’s disease; however, there are…

Neuroscience

Traumatic Brain Injury-Induced Immunological Malfunction of the Gut-Brain Axis

June 22, 2023 Priyanka Basu

Priyanka Basu Background: Traumatic brain injury (TBI) is a global public health issue affecting millions of people each year with more than 64,000 deaths in the United States in 2020.1 It is commonly caused by a bump or blow to the head. Recent advances in research have confirmed that the…

Featured Abstracts Gastroenterology Neuroscience

Balance of Activity of D1Rs and D2Rs on Medium Spiny Neurons in the Striatum Can Explain Persistence of Alcohol Seeking Behavior in Alcohol Use Disorder

June 22, 2023 Madelyn Pegues

Madelyn Pegues Background: Alcohol use disorder is a significant contributor to preventable death and economic burden both in the United States and globally.1 There is a large treatment gap due to the stigma surrounding mental health disorders and even individuals that receive treatment continue to have high relapse rates.2 Understanding…

Featured Abstracts Neuroscience

Exon Skipping for Specific Duchenne Muscular Dystrophy Mutations

June 22, 2023 Deep Parikh

Deep Parikh Background: Duchenne Muscular Dystrophy (DMD) is a lethal neuromuscular disorder that affects almost 1 in 3500 males and is seen in boys around the ages 3-4. The disease symptoms progress very quickly following this.1 DMD is an X-linked disorder that occurs due to mutations of the dystrophin gene…

Featured Abstracts Neuroscience

Investigating the Roles of the Innate and Adaptive Immune Systems in Alzheimer’s Pathogenesis

June 22, 2023 Oliver Zhou

Oliver Zhou Background: Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by buildup of amyloid-β plaques, neurofibrillary tau tangles, and neuroinflammation that leads to progressive memory loss and cognitive decline.1 It is the most common neurodegenerative disorder and contributes to an estimated 60-80% of dementia cases worldwide.1 It is…

Featured Abstracts Immunology Neuroscience

The role of NR3C1 on Susceptibility and Manifestation of Post-Traumatic Stress Disorder

June 22, 2023 Faith Nguyen

Faith Nguyen Background: Post-traumatic stress disorder (PTSD) is a pathogenic response to a traumatic event that affects approximately 6% of the world1 with reports higher in the younger population, females, and first responders4. PTSD has varied manifestations and treatment; however, there is currently no pharmacological therapy used to solely treat…

Neuroscience

Protecting Dopaminergic Neurons: Sigma-1R Agonists as Potential Parkinson’s Treatment

June 22, 2023 Gor Kikanian

Gor Kikanian Background: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, leading to motor symptoms such as tremors, rigidity, and bradykinesia. The Sigma-1 receptor (Sig-1R) is a unique transmembrane protein located in the endoplasmic reticulum that is…

Featured Abstracts Neuroscience

Hippocampal Adaptations Contributing to Changes in Memory Performance Following Mild Traumatic Brain Injury

June 21, 2023 Zain Syed

Zain Syed Background: Traumatic brain injury (TBI), resulting from an impact to the head, leads to impairments in neurological function that can be temporary or permanent.1 A case of TBI is classified as severe, moderate, or mild, if assigned a Glasgow Coma Scale score of 3-9, 9-12, or 13-15, respectively.2…

Featured Abstracts Neuroscience