Category: Orthopedics

Immunogenic Origin of Dupuytren’s Disease Suggests Need for Endogenous Treatment to Prevent Progression and Post-Operative Recurrence and Extension

July 26, 2021 Sophie D. Curie
Sophie D. Curie, MBA Introduction: Dupuytren’s disease (DD) is an irreversible progressive fibroproliferative disorder of the hand manifesting as function-limiting nodules and cords surrounding phalangeal tendons, primarily affecting older males of northern European descent.1 DD fibrosis is characterized histologically by mesenchymal cells, immune cells, and ECM proteins and is treated…
Immunology Orthopedics

Micro RNA-Induced Osteogenic Differentiation of Mesenchymal Stem Cells to Osteoblasts in Osteoporosis

July 23, 2021 John Burton
John Burton Introduction. Osteoporosis is a major concern worldwide and can be attributed to a metabolic imbalance between osteoblastic bone formation and osteoclastic bone resorption that increases bone fragility and fracture risk1. More than 75 million people are currently living with osteoporosis and many more have osteopenia2. There are many…
Orthopedics Stem Cells

The Role of TGF-β3 on Mesenchymal Stem Cell Chondrogenesis and the Potential for Therapeutic Use in Osteoarthritis

August 12, 2020 Peter Duong
Peter Duong Osteoarthritis (OA), currently the most common form of arthritis, is a progressive degenerative disease affecting the joint cartilage and surrounding joint infrastructure1,2. Treatments for OA are limited to pain relief and functional rehabilitation1,2. Regeneration of cartilage in the affected joint(s) provide potential solutions to reverse degeneration of joint…
Orthopedics Stem Cells

Mesenchymal Stem Cell-Derived Exosomes Suppress Cartilage Degradation via A WNT5A-Dependent Mechanism: Implications for Osteoarthritis Therapy

August 11, 2020 R. Kenneth Sims IV
Kenneth Sims IV Introduction.  Osteoarthritis (OA) is a “wear-and-tear” disease in which synovial joints, such as the knee or shoulder, degenerate over time. This disease can cause significant pain and immobility, and there is a need for therapy beyond symptomatic management.  Within the OA joint, chondrocytes lose the ability to…
Orthopedics Stem Cells

Repair of Bone Fracture Non-Union with BMP-2 Growth Factor on Hydroxyapatite Scaffolds

July 7, 2020 Amy Zhou
Amy Zhou  Introduction Fracture non-union (failure to heal) is a major clinical problem exhibiting a prevalence of 5-10% in bone fracture patients.(1) Currently, there are four options of bone fracture repair: autografts, allografts, xenografts, and synthetic bone scaffolds.(2) Synthetic bone scaffolds provide unique opportunities to simultaneously reduce graft rejection, prevent…
Orthopedics

The Role and Mechanisms of lncRNA H19 in Osteoblast Differentiation; Consequence for Regeneration After Bone Trauma

July 7, 2020 M. Abby Yovic
Abby Yovic Introduction. The first step with any fracture is stabilizing and aligning the bone so that repair can start. Overall, fracture non-union rate is 4.93%. Recent research indicates MSCs provide options for cellular based therapies for bone repair due to their strong multipotentiality and regenerative properties. Maternally imprinted, lncRNA…
Orthopedics

Use of Synovium-Derived Mesenchymal Stem Cells to Form Scaffold-Free Tissue Engineered Construct to Promote Repair of Knee Chondral Lesions to Prevent Development of Osteoarthritis

July 6, 2020 Victoria Hamilton
Victoria Hamilton  Introduction: Osteoarthritis (OA) is the most common joint disorder in the world (global prevalence 3.8%) and significantly contributes to disability globally.1–3 OA of the knee (KOA) has the highest incidence in the body, with a lifetime risk of approximately 45%.3 Mesenchymal stem cells (MSCs) are heterogenous stem cells…
Featured Abstracts Inflammation Orthopedics Stem Cells