Differentiation of Induced Pluripotent Stem Cells for the Reversal of Type 1 Diabetes
Kacie Kerlee Introduction. Type 1 Diabetes Mellitus (T1DM) is an autoimmune disease resulting in the destruction of beta-cells within the islet of Langerhans of the pancreas via macrophages and self-reactive CD4+ & CD8+ T-cells.2, 6, 7 This damage to the beta-cells results in a lack of insulin and thus hyperglycemia…