Khalid Alhreish Introduction: Gliomas represent the most common primary brain tumor in adults1. They remain incurable despite current therapies, which are plagued by high morbidity and mortality. The isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) genes are mutated in 50-80% of astrocytomas, oligodendrogliomas or oligoastrocytomas of grades II and III,…