The Role of Early Pregnancy’s Downregulation of Hormone Responsive Cells and Wnt Signaling Pathway in Breast Cancer Protection

Haley Griffin  Introduction: Breast cancer is the predominant cancer and second cause of death due to women. The mammary epithelium undergoes extensive changes throughout a women’s life, and these developmental alterations are associated with progesterone and estrogen. As a result, ER+/PR+ subtype breast cancers are especially linked to reproductive risk factors. The Wnt signaling cascade […]

Exploring the role of inflammation in colorectal carcinogenesis, and the use of Fc receptor-targeted therapies to target inflammation-mediated cancer development

Rihin Chavda Introduction: It is well established that inflammation is strongly associated with colorectal carcinogenesis. Pathology of acute and chronic inflammation contribute to genomic damage and promotion of cancer (7). Fc therapy has been exploited in many forms of cancers to deliver immunoconjugates that deliver the toxin or radioisotope readily. The delivery of anti-inflammation Fc […]

Blocking immunosuppressive molecules, PD-1 and CTLA-4, as an anti-cancer immunotherapeutic strategy

Cherry Chau Introduction. Cancer immunotherapy has sometimes been referred to as the “holy grail of oncology” because it activates the patient’s own immune system to kill cancer cells. PD-1 and CTLA-4 have long been identified as potential targets for immunotherapy.1 They are receptors that downregulate T-cell activity to “turn off” the immune system after an […]

Using CRISPR Cas9 Gene Editing to Generate CAR (Chimeric Antigen Receptor) T-Cells for Immunotherapeutic Treatment of Leukemia

Jeffrey Cao Background: Leukemia is a cancer in which blood-forming tissues like bone marrow generate high numbers of immature or abnormal leukocytes, suppressing the production of normal blood cells. Like most cancers, malignant cells in leukemia exhibit immune evasion and resist checkpoint inhibition, which pose challenges to therapy. To overcome this, CRISPR Cas9-gene editing is […]

MTHFD2, a mitochondrial gene involved in 1-carbon metabolism, plays a key role in breast cancer proliferation

Shrishiv Timbalia Introduction: Breast cancer is a leading cause of disease and mortality in women, with over 1,500,000 women diagnosed with and 500,000 dying of breast cancer worldwide annually1. Because of breast cancer’s genetic factor and mortality rate, it is critical to discover methods for detecting and treating this disease. The mitochondrial 1-carbon synthetic pathway […]

Combinatorial blocking of immunosuppressive molecules, PD1 and CTLA4 as an anti-melanoma immunotherapeutic strategy

Georgina Kolcun Immune checkpoint blockade has proved to be an auspicious therapeutic strategy in the field of cancer immunotherapy. Immune checkpoints are points at which the immune system may either stimulate or inhibit its immune response. The immune system may feel the need to heighten its response at the threat of foreign molecules and in […]

The role of the Keap1/Nrf2 signaling pathway in the pathogenesis of non-small cell lung cancer and induction of cancer treatment resistance

Allen Jacob  Introduction. Lung Cancer has been identified by the National Cancer Institute of the NIH as the leading cause of mortality among all cancers in the United States, with an estimated 155,870 deaths in 2017 alone. Non-small cell lung cancer (NSCLC) encompasses 85% of lung cancer diagnoses, and a normal pathway that is often […]