Structural Mechanisms of PD-1 – SHP2 Signaling

Eric Zhang Introduction: Colorectal cancer (CRC) is the 3rd most common cancer globally, and the 4th most common cause of cancer mortality1. Inflammatory bowel disease (IBD) ranks as a major predisposing factor for the development of CRC, termed colitis-associated colorectal cancer (CAC) when caused by inflammatory etiologies2. Src homology region…
Cancer

The Role of Selected MicroRNAs (miRNAs) in the Negative Regulation of Pediatric Retinoblastoma Progression

Ashtyn Zapletal Introduction. Retinoblastoma (Rb) is an autosomal dominant retinal cancer usually affecting children ages 15 months – 24 months, counting for roughly 9,000 new cases each year.1,2 Common treatments for Rb include intra-ophthalmic and intra-vitreal chemotherapy, as well as enucleation3. To mitigate the harsh side effects of these current…
Cancer

The Impact of Sex-Based Differences in Glioblastoma Multiforme (GBM): Tumor Suppressor Proteins TP53, TP16, and TP21

Caren Stuebe  Introduction. Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor.1 GBM is characterized as a grade IV glioma diagnosed with imaging and biopsy.2,3 With standard of care treatment of  maximal surgical resection, radiation, and temozolomide chemotherapy, median survival is 12-14.6 months.1,2,3,4 Of note is the…
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