Category: Cancer

Role of IDH1-R132H in tumor progression of gliomas

April 8, 2021 Khalid Alhreish
Khalid Alhreish Introduction: Gliomas represent the most common primary brain tumor in adults1. They remain incurable despite current therapies, which are plagued by high morbidity and mortality. The isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) genes are mutated in 50-80% of astrocytomas, oligodendrogliomas or oligoastrocytomas of grades II and III,…
Cancer

Early life exposure to soy affects breast cancer susceptibility through regulation of ER and cytokines

October 12, 2020 Bailey King
Bailey King  Introduction. Breast cancer is the most common non-cutaneous cancer in women in the US.  Studies have found significant differences in the microbial composition between breast cancer patients and non-breast cancer patients.1 The diet affects breast cancer risk through multiple mechanisms, including estrogen and cytokines. Estrogens influence mammary gland…
Cancer Nutrition

Structural Mechanisms of PD-1 – SHP2 Signaling

July 7, 2020 Eric Zhang
Eric Zhang Introduction: Colorectal cancer (CRC) is the 3rd most common cancer globally, and the 4th most common cause of cancer mortality1. Inflammatory bowel disease (IBD) ranks as a major predisposing factor for the development of CRC, termed colitis-associated colorectal cancer (CAC) when caused by inflammatory etiologies2. Src homology region…
Cancer

The Role of Selected MicroRNAs (miRNAs) in the Negative Regulation of Pediatric Retinoblastoma Progression

July 7, 2020 Ashtyn Zapletal
Ashtyn Zapletal Introduction. Retinoblastoma (Rb) is an autosomal dominant retinal cancer usually affecting children ages 15 months – 24 months, counting for roughly 9,000 new cases each year.1,2 Common treatments for Rb include intra-ophthalmic and intra-vitreal chemotherapy, as well as enucleation3. To mitigate the harsh side effects of these current…
Cancer