Jacob Moser Introduction. Many chronic inflammatory diseases like asthma, rheumatoid arthritis, and many others owe their pathogenicity to ‘typical’ inflammatory cytokines like TNFa, and can be targeted clinically by widely used drugs like Adalimumab (Humira). But recently discovered types of […]
Sara Yasrebi Introduction. Alzheimer’s Disease is the 6th leading cause of U.S. deaths. and of the top 10, it is the only one without a known cause or cure.1 This age-related neurodegenerative disease is caused by the action of b-secretase […]
Michael Woolley Introduction. Alzheimer disease (AD) is the leading cause of dementia in the United States1. As many as 5 million new cases are diagnosed each year, and that number is expected to increase as the Baby Boomer generation ages2. […]
Devon Weidner Introduction. Treatment Resistant Depression (TRD) affects 1% of individuals in the US and 30% of depressed patients1. Patients with treatment resistant depression are those who have been unsuccessful with treatment from two different classes of antidepressants for a […]
Eric Swanson Introduction. Hypertension (HTN) is the leading cause of stroke, disease burden and death worldwide (1) In the United States, it affects 46% of adults and it is estimated that 13-17% of adults with HTN have uncontrolled or resistant […]
Soumya Shekhar Introduction. Pancreatic ductal adenocarcinoma (PDAC) remains as one of the deadliest types of cancer, with 5-year survival rates remaining around 3% (1). PDAC tends to metastasize earlier than other types of cancer, so the efficacy of traditional first-line […]
Varada Salimath Introduction. Retinoblastoma is the most frequently occurring pediatric ocular cancer.1 It arises from mutation in both alleles of the tumor suppressor gene Rb1 on chromosome 13, which codes for the cell cycle regulating retinoblastoma protein (pRb).2 Symptoms include […]
Sonia Rao Introduction. Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer in the world with a 5-year survival rate of only 5%, demonstrating the need for improved treatments1,2. Risk factors for HCC include alcohol consumption and diabetes, and […]
Neha Pal Introduction. Triple-negative breast cancers (TNBCs) account for approximately fifteen percent of breast cancers, and they lack the presence of the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). Because targeted therapies rely on […]
Jonathan Lutgens Introduction. Asthma is a complex disease associated with airway inflammation, mucus hypersecretion, and bronchoconstriction1. In older literature, asthma was seen as simply an IgE-mast cell mediated response. However, recent studies have had a greater focus on the different […]