Courtney Welch Introduction. Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, and the risk increases with age so that by age 85 some studies suggest that ∼50% of individuals will have the disease1,2. The pathological hallmarks of AD include […]
Hasan Sumdani Introduction. Autism Spectrum Disorder (ASD) is a neurological condition characterized by behavioral changes such as decreased sociality, limited range of interests, and repetitive behaviors. The etiology of ASD has a large genetic component, but environmental causes are being […]
Marisa Pinson Introduction. Preeclampsia (PE) is defined by new onset hypertension and proteinuria by ≥20 weeks of gestation.1-4 PE occurs in 2-5% of pregnancies and is the leading cause of maternal and fetal morbidity and mortality globally.1 Currently, the only treatment for […]
Virginia B. Neese Introduction: Myocardial infarction (MI) remains the leading cause of mortality and morbidity in developed countries1. MIs account for up to 700,000 deaths annually in the United States2. Current management focuses on revascularization to prevent further damage, but […]
Ryan Morris Introduction: CRISPR, Clustered Regularly Interspaced Palindromic Repeats, has stormed onto the scientific stage in a relatively short period of time and is at the forefront of gene-editing technology. Originally discovered as an adaptive immunity system against bacteriophages in […]
Kathleen F. Lundquist Introduction. Spondylolisthesis is defined as the forward slippage of a vertebra without rupture of the posterior arc, usually inducing lumbar canal stenosis with a prevalence estimated at 2.7% in males and 8.1% in females2. Spondylolisthesis is frequently […]
Tanner Lines Introduction: Breast cancer is the most common malignancy in women and the third most common cancer worldwide behind lung and colon cancer1,2. Triple-negative breast cancer (MDA-MB-231) represents 10-20% of all breast cancer cases and lacks the progesterone, estrogen, […]
Lyndon Lee Introduction: Epithelial-to-mesenchymal transition (EMT) is implicated in the acquisition of an invasive and treatment resistant phenotype in cancer, and is characterized by the loss epithelial characteristics.1-3 Mesenchymal characteristics include the gain of a leading/trailing edge, upregulation of mesenchymal […]
John Hiett Introduction. Autism spectrum disorder (ASD) is a developmental disability that includes social and communication impairments, restricted interests, and repetitive behaviors. Although the etiology of ASD in not completely known, a very strong genetic component has been identified.5 Compared […]
Kevin M. Claunch, M.S. Introduction. The Unfolded Protein Response (UPR) is a critical homeostatic pathway in mammalian cells that is triggered by ER dysfunction and subsequent accumulation of misfolded and damaged proteins1,7. Activation of the UPR is achieved through three […]