Brittany Witt Introduction. Autism Spectrum Disorder (ASD) includes a broad range of social communication deficits characteristically accompanied by repetitive patterns of behavior, GI disturbances, and self-injury.1,2 Approximately 1 in 59 children have ASD in the US, making the disorder increasingly […]
Edward Parker Whitfield Introduction: Anaplastic thyroid carcinoma (ATC) arises in the follicular cells of the thyroid gland5. Unlike the 90% of follicular carcinomas that are well differentiated, ATC exhibits a high level of dedifferentiation, local aggression, metastasis, and fatality5,6. ATC […]
Stav Cullum Introduction. Epithelial-mesenchymal transition (EMT) is a process by which cells lose epithelial and gain mesenchymal characteristics, allowing migration for physiological (development) or pathological (metastatic) purposes.1 Once a tumor cell loses expression of cellular adhesion protein E-cadherin, it is […]
Rishi Suresh Introduction. Ischemic stroke is a condition in which the brain is abruptly deprived of oxygen, leading to functional deficits. Epidemiologic studies have shown that young women experience strokes less frequently than similarly aged men; however, this trend reverses […]
Alan Hodges Introduction. Systemic Lupus Erythematosus (SLE) is an autoimmune disorder involving multiple organ systems with a wide range of clinical manifestations commonly including arthritis, nephritis, neurologic disorders and hematologic disorders. SLE affects approximately 1 in 2500 people with a […]
Erin Sigler Introduction: Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables that is associated with the prevention of multiple cancers1. Skin cancer incidence is on the rise globally and can be resistant to treatments2,3. Studies investigating the role of […]
Kirtan Patel Introduction. Systemic Lupus Erythematosis (SLE) is a chronic autoimmune inflammatory disorder in which anti-nuclear antibodies are thought to cause multi-organ damage2,3,7. Studies have found that plasmacytoid dendritic cells (pDC) are at the center of SLE pathogenesis as they […]
Autumn Brewer Introduction. Parkinson’s Disease (PD) is a progressive, neurodegenerative disease of the basal ganglia that primarily affects movement initiation and motor control.1 A key pathological hallmark of PD is the death of dopaminergic neurons in the substantia nigra.1,2 This […]
Monica Sosa Introduction: Ovarian cancer (OC) is one of the most lethal gynecological malignancies.1,2 Currently there are no diagnostic approaches to screen for early stage OC, with most cases being detected in the advanced stages (Stage III-IV).2 Furthermore, once the […]
Ali Imran Alwani Introduction: Ovarian cancer is a leading cause of death caused by cancer in females1,2,3, and the stage of the disease determines the prognosis, with a 5-year survival rate for Stage IV cancer being around 20%4. As a […]