Jonathan Lutgens Introduction. Asthma is a complex disease associated with airway inflammation, mucus hypersecretion, and bronchoconstriction1. In older literature, asthma was seen as simply an IgE-mast cell mediated response. However, recent studies have had a greater focus on the different […]
Steven Le Introduction. Breast cancer is the most diagnosed cancer in women and evidence in research shows that breast cancer is becoming more prevalent in developed countries. Treatments depends on the cancer state, genomic markers, patient’s age, and known mutations […]
Ariane Kubena Introduction. Lung cancer is the leading cause of cancer-related deaths worldwide, and 85% of cases are diagnosed as Non-Small Cell Lung Cancer (NSCLC). 70% of NSCLC diagnoses present at an advanced stage with a 15% 5-year survival rate […]
Pouriska Kivanany Introduction. Diabetes is characterized by elevated blood glucose levels, decreased blood circulation, and reduced immune response.1, 2 Diabetic foot ulcers are the primary complication with diabetes and are responsible for 84% of diabetic lower leg amputations.3 In normal wound healing, […]
Candice Hill Introduction. Over 25 million people in the world are affected by dementia, most suffering from Alzheimer’s Disease (AD), a progressive neurodegenerative disease caused by an accumulation of Aβ amyloid3. However, what triggers this Aβ accumulation has yet to […]
Samantha Fine Introduction: The gene Succinate Dehydrogenase Flavoprotein Subunit A (SDHAP3) has epigenetic alterations in fetuses exposed to maternal smoking and other neurodevelopmental disorders such as autism spectrum disorder (ASD), schizophrenia, and down syndrome (DS)1-4. Although maternal smoking during pregnancy […]
Caleb Ellis Introduction. Multiple Sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system that leads to progressively worsening and permanent neurological defects.1 MS is characterized by the activation of aberrant T-cells which then recognize and destroy myelinated […]
Morgan Cattoor Introduction. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease driven by aberrant responses in both innate and adaptive immunity.1 Standard treatment consists of immunosuppressive agents such as corticosteroids, azathioprine, and methotrexate.2 When these therapies fail, mesenchymal stem […]
Nitheesha Alapati Introduction. High rate of mortality associated with epithelial ovarian cancer is due to the tumor recurrence and resistance to multiple drugs after good initial response to the standard chemotherapy with drugs such as platinum/taxanes1. This occurs in a […]
Brittany Witt Introduction. Autism Spectrum Disorder (ASD) includes a broad range of social communication deficits characteristically accompanied by repetitive patterns of behavior, GI disturbances, and self-injury.1,2 Approximately 1 in 59 children have ASD in the US, making the disorder increasingly […]