Category: Featured Abstracts

The Significance of LINE-1 in Huntington Disease

June 30, 2022 Wahibah Hannan
Wahibah Hannan Huntington Disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor impairment, psychiatric disturbances, and cognitive decline1. HD is caused by an expansion of a CAG trinucleotide repeat in the huntingtin gene. The mutant huntingtin protein gains toxic function and results in neurodegeneration, specifically in the…
Engineering Medicine Featured Abstracts Neuroscience

Applications of Functional Connectivity in Assessing Brain Network Damage in Multiple Sclerosis Patients

June 27, 2022 Khue Tran
Khue Tran and Ian Murray, PhD Introduction: Multiple sclerosis (MS) is a chronic autoimmune, inflammatory disease of the central nervous system, characterized by acute demyelinating attacks and progressive neurodegeneration.1-4 MS can manifest into a wide range of symptoms, including physical disability, cognitive impairment, and decreased quality of life.3-5 Although the…
Engineering Medicine Featured Abstracts Neuroscience

The Role of Cardiomyocyte Mitochondrial AMPK and ATP Synthase in Hypertrophic Cardiomyopathy (HCM)

June 27, 2022 Divek Toprani
Divek Toprani Introduction. Hypertrophic Cardiomyopathy (HCM) is a cardiovascular disease affecting 1 in 500 people where heart muscle becomes abnormally thick.1 HCM can manifest as a left ventricular outflow tract obstruction, left ventricular hypertrophy, or a non-obstructive form with wall thinning and dilation of the cavity.1 HCM is characterized by…
Cardiology Engineering Medicine Featured Abstracts

Downregulation of IL-1B Pathway in Tumor Microenvironment Demonstrates Therapeutic Potential in Slowing Proliferation and Development of Breast Cancer Bone Metastases

June 27, 2022 Pujita Munnangi
Pujita Munnangi Introduction. Breast cancer (BC) is the most prevalent form of cancer impacting women across the globe; 75% of patients with stage IV BC develop bone metastases.1 Skeletal metastases lead to increased risk of fractures, weakened bones, severe pain and disability, and decreased mobility due to the development of…
Cancer Engineering Medicine Featured Abstracts

Cellular Senescence Is Associated with Phenotypic Changes that Promote Inflammation and Aging

June 27, 2022 Emily Lo
Emily Lo Introduction: Cellular senescence is a cell stage associated with DNA damage in which a cell can no longer replicate and gains resistance to apoptosis1. Senescent cells secrete an array of inflammatory cytokines and chemokines, including TNF-alpha, IL-6, and IL-81. Accumulation of senescent cells and their associated inflammation is…
Aging Engineering Medicine Featured Abstracts Inflammation

Impact of B-adrenergic Receptors in the Development, Diagnosis and Treatment of Takotsubo Cardiomyopathy

June 27, 2022 Paulamy Ganguly
Paulamy Ganguly Introduction: The etiology of takotsubo cardiomyopathy (TCM) is poorly understood, yet the increased concentration of catecholamines is most often implicated in disease pathophysiology(1). Under stressful conditions, influx of catecholamines stimulates B-adrenergic receptors which leads to cardiomyocyte necrosis and toxicity(1). Patients with TCM present with chest pain, dyspnea or…
Cardiology Engineering Medicine Featured Abstracts

Will Staphylococcus Be the Key to Our Next Skincare Craze? Harnessing the Power of Staphylococcus Epidermidis to Treat Plaque Psoriasis

June 24, 2022 Alexandra Farhangui
Alexandra Farhangui Introduction. Staphylococcus epidermidis is a common skin bacterium that has been shown to both promote wound healing and increase ceramide levels on the skin.1, 2 Ceramides are lipids derived from sphingomyelin and have been shown to be protective against skin water loss.3 Additionally, the absence of ceramide has…
Engineering Medicine Featured Abstracts Microbiology

IL-6 Signaling in Pulmonary Arterial Hypertension as a Potential Therapeutic Target

June 23, 2022 Michael D. Woods
Michael D. Woods Introduction. Pulmonary arterial hypertension (PAH) is a rare chronic disease characterized by a mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg in the setting of pulmonary vascular disease.1 Chronic inflammation drives the endothelium and pulmonary artery smooth muscle cells (PASMC) to resist apoptosis, proliferate, and migrate, resulting…
Cardiology Featured Abstracts