Disrupted Photoreceptor Outer Segment Degradation Induces Retinal Pigment Epithelium Senescence and Complement Dysregulation in Age-Related Macular Degeneration

Zachary I. Richards  Introduction. Age-related macular degeneration (AMD) is the top cause of vision loss for those over 70.1 The disease presents with central photoreceptor loss and irreversible central blindness.1 Two types of AMD predominate, wet and dry. Wet AMD is a disease of neovascularization in the choroid, while dry…
Featured Abstracts Ophthalmology

Calorie Restriction Promotes Myelin Formation by Activating AMP-Activated Protein Kinase: Implications for Multiple Sclerosis Treatment

Pranav Gadangi Introduction. Multiple sclerosis (MS) is a chronic, autoimmune disease of the central nervous system that leads to demyelination and neurodegeneration in nearly 200 patients per week1. The condition starts in a relapsing-remitting form for the first 10-15 years followed by a severe, progressive form that decreases life expectancy…
Featured Abstracts Neuroscience

Elucidating Mechanisms Underlying MicroRNA as a Biomarker and Therapeutic Target in Strokes

Antara Dattagupta Introduction: Stroke is one of the leading causes of adult mortality and disability worldwide.1 During ischemic stroke, neurons are deprived of oxygen and energy and their normal metabolic substrates stop functioning in seconds displaying signs of structural injury after only two minutes.2 MiRNA are post- transcriptional regulators that…
Cardiology Featured Abstracts

Inhibition of C-C Chemokine Receptor 5 (CCR5) Can Increase Synaptic Plasticity, Enhancing Motor Recovery and Brain Function After Stroke

Darshil Choksi Introduction. A stroke is an interruption of the blood supply to the brain and kills about 140,000 Americans every year1; it is the leading cause of long-term disability in the United States.1 The identification of a specific process that governs the ability of the brain to recover from…
Cardiology Featured Abstracts

The Role of TREM2 in Microglial Activation, Phagocytic Function, and the Pathogenesis of Alzheimer’s Disease

Macy Zardeneta Introduction: Alzheimer’s disease, the sixth leading cause of death and most common, known cause of dementia, displays molecular hallmarks including neurotoxic amyloid plaques and neurofibrillary tau tangles, resulting in brain atrophy, cognitive decline, and memory loss.1,2  Microglia, resident immune cells of the brain, have been noted to potentially…
Featured Abstracts Neuroscience

The Impact of Sex-Based Differences in Glioblastoma Multiforme (GBM): Tumor Suppressor Proteins TP53, TP16, and TP21

Caren Stuebe  Introduction. Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor.1 GBM is characterized as a grade IV glioma diagnosed with imaging and biopsy.2,3 With standard of care treatment of  maximal surgical resection, radiation, and temozolomide chemotherapy, median survival is 12-14.6 months.1,2,3,4 Of note is the…
Cancer Featured Abstracts