The Role of Polycystin 1 and Polycystin 2 (PC1/PC2) in Calcium Intake and Pathogenesis of Autosomal Dominant Kidney Disease

Tarek Dawamne Introduction. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common potentially lethal single gene disorder. ADPKD is often associated with renal cysts that cause increased kidney malfunction such as hematuria, flank pain, kidney stones, carcinoma, in addition to other cardiovascular abnormalities1.  Methods. Many sources were reviewed to…
Featured Abstracts Renal Genitourinary

Psilocybin Promotes Neuroplasticity through 5-HT2A Receptor agonism: Implications for Treatment of Depression

Brianna Peacock Introduction. Depression is a state of low mood with a lifetime prevalence of about 20% globally.1 Potential etiologies include the monoamine hypothesis which describes a decrease in molecules like serotonin.1,2 Loss or alteration of neuroplasticity may also play a role in pathogenesis, as suggested by the decreased BDNF…
Featured Abstracts Neuroscience Psychiatry

Minimally Invasive Preimplantation Genetic Testing for Aneuploidy in In vitro Fertilization

Natalie Miroballi Introduction. Infertile individuals often seek assisted reproductive technology (ART) to aid in conception, the most common of which is In vitro fertilization (IVF) therapy. The success rate of IVF is highly variable and depend on several clinical factors including the underlying causes of infertility and the woman’s age.…
Featured Abstracts Gynecology Reproduction

Using Deferoxamine to Improve Soft Tissue Regeneration following Achilles Tendon Repair

Will Singer Introduction. The Achilles tendon is the strongest tendon in the body and facilitates walking, running, and jumping movements.1 Despite its strength, the incidence of Achilles tear has reached approximately 8.3 ruptures per 100,000 people over the last several years due to increased participation in recreational activities.2 Surgical management…
Featured Abstracts Orthopedics Wound Healing

Gut Dysbiosis in Type 1 Diabetes: Islet Cell Cytokine Response to Co-Culture with Bacteroides Dorei

Tanner Walker Introduction. Type 1 diabetes (T1D) is a chronic autoimmune disease, affecting 1.6 million Americans, that destroys β cells in the pancreas resulting in chronic hyperglycemia if left untreated with daily exogenous insulin 1 – 4. With 64,000 Americans being newly diagnosed each year, a juvenile onset, and a…
Endocrinology Featured Abstracts Microbiology

The Role of DNA Methylation as an Epigenetic Mechanism of the Neuroadaptations Associated with Cocaine Use Disorder

Rachael Wong Introduction. Cocaine use disorder is 79% heritable, and 2 million Americans use cocaine monthly with over 850,000 of them meeting the DSM-V criteria for cocaine dependence.5,9 While identification of specific genetic factors and pharmacological treatment has remained elusive, promising results are arising from the study of epigenetic modifications…
Featured Abstracts Neuroscience Psychiatry

Targeting the Sct/SR/TGF-β1 Axis to Delay Fibrosis in Primary Sclerosing Cholangitis

Kendal Updike Introduction. Primary Sclerosing Cholangitis (PSC) is a cholestatic liver disease affecting bile modification due to damage to cholangiocytes and intra- and extra-hepatic bile ducts1-3. Cholangiocytes are the only cell type in the liver that secrete secretin and express the G-protein coupled secretin receptor3. Through an autocrine mechanism, secretin…
Featured Abstracts Hepatology

The Mechanistic Basis of Monoclonal Antibodies in Reducing the Progression of COVID-19 & Effectiveness Against SARS-CoV-2 Variants

Rahul Tharoor Introduction. COVID-19 is a respiratory illness that as of June 4, 2021, has infected over 170 million people and led to the death of over 3.7 million individuals globally.1 The SARS-CoV-2 virus may cause injury by binding to and downregulating ACE-2 receptors, as well as activating mass inflammatory…
Featured Abstracts Microbiology

The Role of Arginase in the Development of Diabetes-Associated Vascular Dysfunction

Nicholas Tan Introduction: Type II diabetes mellitus (T2DM) is a metabolic disorder affecting approximately 415 million people worldwide.1,2  The disorder develops as the result of relative insulin deficiency due to insulin resistance or loss of function in pancreatic-ꞵ-cells.3 Cardiovascular disease (CVD) is commonly associated with diabetes, with diabetic patients having…
Cardiology Endocrinology Featured Abstracts