Category: Featured Abstracts

EphA4 in Alzheimer’s Disease: A Pathogenic Driver and Promising Therapeutic Target

October 22, 2025 Hannah Whittaker
Hannah Whittaker Background: Alzheimer’s disease (AD) is the most common form of dementia characterized by the decline of memory and cognitive function, eventually leading to profound dementia and death.1­ The two classical pathological features of AD are extracellular amyloid plaques and intraneuronal neurofibrillary tangles (NFTs) comprising phosphorylated tau protein in…
Featured Abstracts Neuroscience

Development of Human Cytomegalovirus Glycoprotein B and Pentamer Complex Subunit Vaccines to Elicit Protective Immune Response Against Congenital Cytomegalovirus Infections

September 15, 2025 Ankita Rao
Ankita Rao Background: Congenital cytomegalovirus infection (cCMV) is the most common congenital infection in the United States, caused by vertical transmission of the human cytomegalovirus (HCMV). cCMV can result intrauterine fetal demise, miscarriage, neurodevelopmental disorders, intracranial abnormalities and sensorineural hearing loss1. Antiviral medications available for treatment of transplant patients cannot…
Featured Abstracts Immunology Microbiology

Therapeutic Advancements for the Treatment of Melanoma: Striving for an Individualized Approach by Targeting MAPK and Hippo Pathways

September 15, 2025 Allison Roecker
Allison Roecker Background: Melanoma is the fifth most common cancer in the United States, and while mortality has decreased due to the approval of new immunotherapy therapies, treatment resistance remains a major hurdle to overcome.¹ Melanoma development and progression is driven by several genetic mutations, and then exacerbated by UV…
Cancer Featured Abstracts

Yoga as a Supplemental Therapy for Pediatric Cystic Fibrosis Patients

September 12, 2025 Swarali Panse
Swarali Panse Background: Cystic fibrosis (CF) is a genetic disorder primarily affecting respiratory function. Conventional physiotherapy and pharmacologic treatments are used in standard CF management, however, interest in complementary therapies like yoga are on the rise. Yoga, known for enhancing respiratory capacity and reducing stress, can potentially be used to…
Engineering Medicine Featured Abstracts Respiratory

The Role of Vitamin K2-MK4 in Parkinson’s Disease

September 12, 2025 Ethan Chow
Ethan Chow Background: Parkinson’s Disease (PD) is the second most prevalent neurodegenerative disease currently affecting an estimated 11.9 million people worldwide, and is projected to exceed 25.2 million by 2050. 1 PD is classically described as neuronal degeneration and alpha-synuclein aggregation in the dopaminergic neurons of the substantia nigra pars…
Engineering Medicine Featured Abstracts Neuroscience

Engineering CAR-T Cells to Enhance Anti-tumorigenic Properties for Cancer Treatment

September 2, 2025 Janssen Fang
Janssen Fang Background: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, which is a cancer primarily affecting the lymphatic system.1 This disease involves “hijacking” cellular mechanisms of differentiation and maturation within the germinal center of lymphoid organs. Currently, the standard treatment for DLBCL is R-CHOP(rituximab,…
Cancer Featured Abstracts Immunology

Advancements in Alzheimer’s Disease Detection and Treatment

August 21, 2025 Adithya Shastri
Adithya Shastri Background: Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes. It currently affects over 6 million Americans and is a leading cause of disability in older adults13. Diagnosis often occurs late, after significant neuronal damage, which limits the effectiveness…
Engineering Medicine Featured Abstracts Neuroscience

The Role of Selective Dopamine D2 Agonists in Promoting Cardiomyocyte Recovery in Oxidative Stress-induced Peripartum Cardiomyopathy

August 12, 2025 Ayesha Sayyed
Ayesha Sayyed Background: Peripartum cardiomyopathy (PPCM), the most common dilated cardiomyopathy affecting previously heart-healthy women during late-term pregnancy, occurs due to left ventricular (LV) systolic dysfunction.1 Factors such as increased maternal age, multifetal pregnancies, pre-eclampsia, hypertension, tocolytic usage, and obesity, increase the risk of PPCM.2-5 PPCM is underdiagnosed due to…
Cardiology Featured Abstracts

Revolutionizing Parkinson’s Disease Treatment: Focused Ultrasound for Non-Invasive Gene Delivery Across the Blood-Brain Barrier

August 12, 2025 Nini Phan
Nini Phan Background: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the accumulation of misfolded α-synuclein protein in Lewy bodies.1 PD is a progressively debilitating condition, marked by the cardinal symptoms…
Featured Abstracts Neuroscience

What Can Be Done to Structurally or Biologically Support the Apophysis of the Tibia in Children Who Suffer from Osgood-Schlatter Disease So That They May Continue Activity During Their Childhood?

August 7, 2025 Boyang Zhang
Boyang Zhang Background: Osgood-Schlatter Disease (OSD) is an activity and growth-associated knee pathology affecting the tibial tuberosity apophysis in adolescents. Up to 10% of adolescents are affected by OSD during their lifetime, often bilaterally.1 While treatment is generally conservative, there is significant variation in patient presentation and symptoms. Usually, patients…
Engineering Medicine Featured Abstracts