Category: Neuroscience

Resting-State fMRI Changes in Motor Network Connectivity Before and After Resection of Low-Grade Gliomas Involving M1 or SMA

July 29, 2026 Chris Oake
Chris Oake Background: Low-grade gliomas (LGGs) frequently arise near eloquent motor regions such as the primary motor cortex (M1) and supplementary motor area (SMA), where even subtle postoperative weakness can significantly impair independence and quality of life1. Conventional structural imaging may underestimate the functional impact of these tumors because network-level…
Cancer Engineering Medicine Featured Abstracts Neuroscience

Stem-Cell Derived: Extracellular Vesicles as a Novel Therapeutic for Alzheimer’s Disease

July 13, 2026 Nidhi Shah
Nidhi Shah Background: Alzheimer’s disease (AD) is a complex, multifactorial neurodegenerative disorder driven by aging, genetic predispositions, and systemic molecular dysregulation.4 The traditional pathogenic model highlights the extracellular deposition of amyloid-beta (Aβ) plaques and intracellular hyperphosphorylated tau tangles.4,5 However, disease progression also involves chronic neuroinflammation mediated by microglia and severe…
Neuroscience Stem Cells

Targeting the NLRP3 Inflammasome for Neuroprotection in Traumatic Spinal Cord Injury

July 13, 2026 Daniyaal Qazi
Daniyaal Qazi  Background: Traumatic spinal cord injury (SCI) is a major cause of permanent neurological disability, affecting approximately 20.6 million individuals globally as of 2019, with an annual incidence of 0.9 million new cases.1 The primary mechanical insult triggers a progressive secondary injury cascade leading to ischemia, glutamate excitotoxicity, oxidative…
Featured Abstracts Inflammation Neuroscience

Neuromonitoring of Modifiable Risk Factors for Post-Operative Delirium

July 7, 2026 Neha Aluru
Neha Aluru Background: Postoperative delirium (POD) is an acute disturbance in attention, awareness, and cognition that affects up to 15-25% of elderly, and is associated with longer hospitalizations, higher complication rates, functional decline, and increased healthcare costs.1 Since POD is linked to substantial short and long-term patient harm, identifying preventable…
Engineering Medicine Featured Abstracts Neuroscience

Mechanistic Drivers of Pathogenic α-Synuclein Secretion: Using Extracellular Vesicles for Prodromal Detection and Glial-Based Therapies for Parkinson’s Disease

July 6, 2026 Heba Ajmal
Heba Ajmal   Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder defined by the intracellular aggregation of α-synuclein and the loss of dopaminergic neurons.2 The prodromal phase can last decades before motor symptoms manifest, offering a critical therapeutic window to intervene before irreversible neuronal loss occurs.2,3 Standard diagnostics for…
Neuroscience

Astrocyte Reactivity in Parkinson’s Disease and its Potential as a Target in Neuroprotective Therapy

July 3, 2026 Mihert Zenebe
Mihert Zenebe Background: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder globally. It is characterized by the degeneration of dopaminergic (DA) neurons in the substantia nigra and aggregates of misfolded α-synuclein (α-syn) within the brain.1,2 Individuals with PD may experience motor and non-motor symptoms that include shuffling gait…
Featured Abstracts Neuroscience

Spinal Cord Injury (SCI): Biological Interventions Shifting Cell Signaling to Prevent Osteoporosis and Promote Repair

July 3, 2026 Samuel Tran
Samuel Tran Background: Spinal cord injury (SCI) leads to rapid deterioration of cortical and cancellous bone below the lesion site, creating significant risk for fractures and limiting rehabilitative options such as weight-bearing exercises and exoskeleton use. ¹ Skeletal deterioration reflects an imbalance between osteoblast and osteoclast function, mainly at the…
Neuroscience Osteoporosis

Predicting the elusive connection between TREM2 and APOE in Alzheimer’s Disease: How Machine Learning can be a useful tool for uncovering hidden patterns in complex diseases

July 3, 2026 Francisco Torres
Francisco Torres Background: Alzheimer’s Disease (AD) is the most common form of dementia, a collection of syndromes characterized by cognitive, behavioral, and functional deficits. Pathological hallmarks of AD include amyloid -plaques (A) and tau protein neurofibrillary tangles (NFTs).[i],[ii],[iii] Although there are two main categories of AD, Familial Alzheimer’s Disease (FAD)…
Featured Abstracts Neuroscience