Sildenafil/Viagra™: Phosphodiestrase-5 Inhibitor and Potential Therapeutic for Neurodegeneration Due to Alzheimer’s Disease

Ayo Isola Introduction Alzheimer’s Disease (AD) is a neurodegenerative condition that represents nearly 70% of dementia cases worldwide1, totaling over 24 million estimated cases worldwide2. AD manifests clinically as gradual personality changes that progress into memory loss, cognitive decline, dementia, and eventual death by infection or a bed ridden-induced blood…
Neuroscience

Abnormal CHD8 Function Leads to Altered Brain Development and Associated ASD Social Behaviors

Nancy Yang Introduction. Autism spectrum disorders (ASD) include a group of neurodevelopmental disorders characterized by core symptoms of social interaction deficits and restrictive, repetitive patterns of behaviors.2 Many ASD risk genes have been identified, and a common ASD-related gene mutation affects the chromodomain helicase DNA-binding protein 8 (CHD8).1,3,4 CHD8 has…
Neuroscience

Understanding the Extent to Which The Gut-to-Brain Axis Contributes to the Pathogenesis of Parkinson’s Disease

Lindsay Wiseman Introduction. Parkinson’s disease (PD) is a central nervous system pathology caused by aggregations of ɑ-synuclein, called Lewy bodies, in dopaminergic neurons of the substantia nigra in the brain.1,2,3 This causes cognitive and motor deficits in PD patients.2 PD is a neurodegenerative disease that cannot be cured yet, but…
Featured Abstracts Neuroscience

Revisiting Alzheimer’s Disease Treatment Using Gamma-Secretase

Alexander Wallace Introduction: Alzheimer’s Disease (AD) is a fatal, progressive neurodegenerative disease that affects over 27 million people worldwide and is characterized by gradual, aggressive cognitive deterioration caused by deposition of amyloid-beta (Ab) after cleavage of amyloid precursor protein (APP) by beta(b)-secretase and gamma(g)-secretase1, 2. Treatment is limited to acetylcholinesterase-inhibitors…
Neuroscience

The Role of COX-2 And PGE2 in the Promotion of Neuroinflammation and Deposition of beta-Amyloid Protein in Alzheimer’s Disease

Chloe Todd Introduction: Alzheimer’s disease (AD) is the leading cause of dementia, projected to affect 150 million people worldwide by 2050.1 Current treatment focuses on improving patients’ symptoms; pharmacological therapy does not yet address disease pathology.2 AD pathogenesis begins with aggregation of β-amyloid (Aβ) protein in the brain.1 Amyloid precursor…
Featured Abstracts Inflammation Neuroscience

Circadian Rhythm Disruption Due to Degradation of Melanopsin Containing Intrinsically Photosensitive Retinal Ganglionic Cells (mRGCs) in Individuals with Parkinson Disease (PD)

Myla Sykes Introduction: PD is caused by alpha-synuclein aggregates in the sub-cortical basal ganglia. Cardinal symptoms of PD include a triad of pill-rolling/resting tremor, bradykinesia, and cogwheel rigidity1,2. In addition, sleep disorders often manifest early in the progression of the disease. mRGCs convey light signals from the retina to the…
Circadian Rhythms Neuroscience