EphA4 in Alzheimer’s Disease: A Pathogenic Driver and Promising Therapeutic Target

Hannah Whittaker Background: Alzheimer’s disease (AD) is the most common form of dementia characterized by the decline of memory and cognitive function, eventually leading to profound dementia and death.1­ The two classical pathological features of AD are extracellular amyloid plaques and intraneuronal neurofibrillary tangles (NFTs) comprising phosphorylated tau protein in…
Featured Abstracts Neuroscience

The Role of Maternal Immune Activation in Autism Spectrum Disorder Pathogenesis

Vanessa Alkarra Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder, affecting approximately 2.2% of adults in the US, and has been increasing in prevalence.1 ASD is characterized by persistent social deficits and repetitive/stereotyped behaviors and its etiology consists of genetic and environmental components. However, mechanisms of ASD pathogenesis are…
Immunology Neuroscience

The Role of Vitamin K2-MK4 in Parkinson’s Disease

Ethan Chow Background: Parkinson’s Disease (PD) is the second most prevalent neurodegenerative disease currently affecting an estimated 11.9 million people worldwide, and is projected to exceed 25.2 million by 2050. 1 PD is classically described as neuronal degeneration and alpha-synuclein aggregation in the dopaminergic neurons of the substantia nigra pars…
Engineering Medicine Featured Abstracts Neuroscience

The Role of Tau Seeds in Tauopathies

Matthew Lin Background: Alzheimer’s disease (AD) is the most common neurodegenerative disease that currently has no effective treatment. Abnormalities with tau protein have been one of the key identifiers of Alzheimer’s disease since the discovery of the disease in 1907.2 These abnormalities in tau can aggregate and form tau seeds…
Neuroscience

Advancements in Alzheimer’s Disease Detection and Treatment

Adithya Shastri Background: Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes. It currently affects over 6 million Americans and is a leading cause of disability in older adults13. Diagnosis often occurs late, after significant neuronal damage, which limits the effectiveness…
Engineering Medicine Featured Abstracts Neuroscience

Revolutionizing Parkinson’s Disease Treatment: Focused Ultrasound for Non-Invasive Gene Delivery Across the Blood-Brain Barrier

Nini Phan Background: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the accumulation of misfolded α-synuclein protein in Lewy bodies.1 PD is a progressively debilitating condition, marked by the cardinal symptoms…
Featured Abstracts Neuroscience

Sex Differences in Traumatic Brain Injury Outcomes in Survivors of Intimate Partner Violence

Caitlin Sannes Background: Intimate partner violence (IPV) is defined as abuse or aggression that occurs in a romantic relationship and includes physical violence, sexual violence, stalking, and emotional abuse and manipulation1. It is currently estimated that one third of women will experience some degree of IPV in their lifetime and…
Engineering Medicine Featured Abstracts Neuroscience

The Lack of Comorbidity Between Early Cortical Blindness and Schizophrenia

Alayne Morrel Background:  It has been noted in several psychiatric studies that there is an absence of reported patients with schizophrenia who had comorbid blindness.¹⁻⁶  This spurred multiple studies ranging from surveying state hospitals to studies encompassing entire populations, such as Australia and Denmark.⁴ ⁷ ⁸ If a correlation exists,…
Engineering Medicine Featured Abstracts Neuroscience

Rewiring Pain: Brain-Computer Interface and Mixed Virtual Reality Approaches to Addressing Phantom Limb Pain

Andres G. Morales-Martinez Background:  Phantom limb pain (PLP) affects up to 64% of amputees and is characterized by painful sensations in the absent limb 1,2. Conventional treatments, including pharmacologic approaches and non-pharmacologic methods like transcutaneous electrical nerve stimulation (TENS) and mirror therapy, often provide inconsistent and short-lived relief without targeting…
Engineering Medicine Featured Abstracts Neuroscience