Sara Yasrebi Introduction. Alzheimer’s Disease is the 6th leading cause of U.S. deaths. and of the top 10, it is the only one without a known cause or cure.1 This age-related neurodegenerative disease is caused by the action of b-secretase […]
Michael Woolley Introduction. Alzheimer disease (AD) is the leading cause of dementia in the United States1. As many as 5 million new cases are diagnosed each year, and that number is expected to increase as the Baby Boomer generation ages2. […]
Michelle Won Introduction. Primary open-angle glaucoma (POAG) affects 70 million patients worldwide and is the second leading cause of blindness. POAG is primarily characterized by disruption of aqueous outflow, leading to high interocular pressure (IOP), causing progressive degeneration of retinal […]
Alyssa Woltemath Introduction: Neonatal hypoxic-ischemic brain injury occurs in 1 to 6 births for every 1,000 live term births4. Researchers worked to understand the pathogenesis mechanism of HIE by upregulation and downregulation of IL-1b, IL-6 and IL-15. Interleukin-1b is produced […]
Brian Scot Welborn II Introduction. Neuronal synaptogenesis is the most sensitive neurodevelopment period. It begins around 20 weeks of gestation and continues throughout adolescence. Repeated or long-term exposure to general anesthetic agents may have a significant impact on synaptogenesis and […]
Devon Weidner Introduction. Treatment Resistant Depression (TRD) affects 1% of individuals in the US and 30% of depressed patients1. Patients with treatment resistant depression are those who have been unsuccessful with treatment from two different classes of antidepressants for a […]
Tam Thanh Nguyen Tran Introduction: Creutzfeldt-Jakob Disease is a rare (1-1.5 cases per million worldwide), rapidly progressive, and inevitably fatal neurodegenerative prion disease involving abnormal protein aggregates that cause brain tissue deterioration (1,2). The normal prion protein PrPC (cellular) is […]
Mario Tovar Introduction. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive corticospinal motor neuron degeneration resulting in death due to respiratory failure within 2-5 years from diagnosis (1,2). ALS has a mean onset age of 55 years […]
Jey Thiruma Introduction. Alcohol use during pregnancy causes Fetal Alcohol Syndrome (FAS), the most severe and visibly identifiable form of the fetal alcohol spectrum disorder. Alcohol is a teratogen, which means that it can easily cross the placenta, and affect […]
Jaqueline Stoutin Introduction. FTLD is a clinically heterogenous disease most often presenting with social disinhibition and apathy (1-5). FTLD is the second leading cause of early-onset dementia after Alzheimer’s Disease. There is currently no treatment for FTLD (1-4). In cases […]