The Significance of LINE-1 in Huntington Disease

Wahibah Hannan Huntington Disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor impairment, psychiatric disturbances, and cognitive decline1. HD is caused by an expansion of a CAG trinucleotide repeat in the huntingtin gene. The mutant huntingtin protein gains toxic function and results in neurodegeneration, specifically in the…
Engineering Medicine Featured Abstracts Neuroscience

CSF Aβ42/Aβ40 is a Potential Predictor of AD Pathology in Comparison to Other Available Biomarkers

Claire Sweeney and Ian Murray, PhD Introduction. Alzheimer’s disease (AD) is a neurodegenerative disease in which tau and amyloid proteins misfold to form pathological neurofibrillary tangles and amyloid plaques.6 There are an estimated 50 million AD patients worldwide and this number is expected to triple by 2050 as the increasing…
Engineering Medicine Neuroscience

Plasma Osteopontin As A Biomarker to Diagnose and Assess Pediatric Traumatic Brain Injury

Sindhura Sridhar Introduction. Pediatric traumatic brain injury (pTBI) is the leading cause of death and disability in children, impacting 475,000 children in the US between the ages 0-14 annually1. Children who experience at least one traumatic brain injury (TBI) are at risk for developing long-term physical, cognitive, and psychological consequences2.…
Engineering Medicine Neuroscience

Nerve Graft Conduits are Beginning to Achieve the Efficacy of Autografts in Radial Nerve Regeneration

James Landry Lilly Introduction. Radial nerve palsies are a broad nerve deficit involving pain, weakness, or loss of function in the extensor forearm and posterior hand. These injuries can commonly be associated with humerus shaft fractures, which are most often caused by motor vehicle accidents, gunshot wounds, and falls from…
Engineering Medicine Neuroscience

Reverse Transcription Pathways Offer Novel Targets for Pharmacological Modulation in the Pathogenesis of Alzheimer’s Disease

Scott Heston Introduction: Multiple processes are theorized to contribute to spontaneous Alzheimer’s Disease (AD). In vivo diagnosis of AD has only become possible in the last decade and requires several measurements including tau and beta-amyloid correlates1. The newfound ability to diagnose AD pre mortem has enabled informed selection of study…
Engineering Medicine Neuroscience

Applications of Functional Connectivity in Assessing Brain Network Damage in Multiple Sclerosis Patients

Khue Tran and Ian Murray, PhD Introduction: Multiple sclerosis (MS) is a chronic autoimmune, inflammatory disease of the central nervous system, characterized by acute demyelinating attacks and progressive neurodegeneration.1-4 MS can manifest into a wide range of symptoms, including physical disability, cognitive impairment, and decreased quality of life.3-5 Although the…
Engineering Medicine Featured Abstracts Neuroscience

The Role of Amyloid Β Plaque Accumulation in Retinal Thickness/Density Changes Observed in Patients With Alzheimer’s Disease and the Potential for Their Use as Disease Biomarkers

Andrew Chapman Introduction: Alzheimer’s disease (AD), is a neurodegenerative disease characterized pathologically by the progressive replacement of neurons with fibrillar amyloid β (Aβ) peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary tangles. Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous…
Neuroscience