The Significance of LINE-1 in Huntington Disease

Wahibah Hannan Huntington Disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor impairment, psychiatric disturbances, and cognitive decline1. HD is caused by an expansion of a CAG trinucleotide repeat in the huntingtin gene. The mutant huntingtin protein gains toxic function and results in neurodegeneration, specifically in the…
Engineering Medicine Featured Abstracts Neuroscience

The Role of Optical, Acoustic, and Human Dependent Technologies In Monitoring Vascular Perfusion After Free Flap Tissue Transfers in Reconstructive Surgery

Raghave Upadhyaya Introduction. Free tissue transfer flaps, or commonly referred to as free flaps, are portions of tissue that can be dissected away from its anatomical location, due to its own unique arterial and venous blood supply,and transplanted into its non anatomical position in the case of injury1. The free…
Cardiology Engineering Medicine

The Role of Sphingolipids in the Creation of Biosensors for SARS-COV-2

Theresa Thurston Introduction. Coronaviruses are enveloped RNA viruses in humans and animals that can cause acute and chronic diseases¹. SARS-CoV-2 is closely related to two bat-derived SARS-like coronaviruses¹, which all use the cellular receptor angiotensin-converting enzyme 2 (ACE2) for entry into cells¹. Nucleic acid detection is the gold standard for…
Engineering Medicine Microbiology

Inhibition of PDE4 and PI3Kδ in Addition to Stimulation of Nuclear Hormone Receptor PPAR in Emphysema Caused By Smoking

Haani Tai Introduction. Smoking-related emphysema induces a disruption to many cellular signaling pathways especially related to inflammation. With inhibition of Phosphoinositide 3-kinase δ (PI3Kδ) showing promising results for reducing inflammation as well as agonizing peroxisome proliferator-activated receptor γ (PPARγ) to induce an anti-inflammatory response and prevent a proinflammatory response.1 Methods. Two…
Engineering Medicine Respiratory

Elucidating the Effect of Nasopharyngeal, Middle Ear, and Salivary Microbiome Changes and use of Antibiotics on the Development of Acute Otitis Media

Kajol Shah Introduction: Acute Otitis Media (AOM) is a middle ear infection that leads to over 5 million pediatric cases and 30 million healthcare visits annually in the US.1 Pediatric populations are more likely to get infections because of eustachian tube anatomy, exposure to pathogens in the environment, and genetic differences…
Engineering Medicine Pediatrics

Relating the Efficacy of Rigid Braces in Treating Adolescent Idiopathic Scoliosis to Patient Quality of Life in Brace

Gabrielle Rogie Introduction. Adolescent idiopathic scoliosis (AIS) is defined as an abnormal lateral curvature of the spine, greater than 10* Cobb angle, without any underlying cause. Scoliosis presents as an abnormal shape of the back and waistline, uneven shoulders, and rib protrusion when instructed to bend forward. Further diagnosis is…
Engineering Medicine Orthopedics

CSF Aβ42/Aβ40 is a Potential Predictor of AD Pathology in Comparison to Other Available Biomarkers

Claire Sweeney and Ian Murray, PhD Introduction. Alzheimer’s disease (AD) is a neurodegenerative disease in which tau and amyloid proteins misfold to form pathological neurofibrillary tangles and amyloid plaques.6 There are an estimated 50 million AD patients worldwide and this number is expected to triple by 2050 as the increasing…
Engineering Medicine Neuroscience