Ayesha Sayyed Background: Peripartum cardiomyopathy (PPCM), the most common dilated cardiomyopathy affecting previously heart-healthy women during late-term pregnancy, occurs due to left ventricular (LV) systolic dysfunction.1 Factors such as increased maternal age, multifetal pregnancies, pre-eclampsia, hypertension, tocolytic usage, and obesity, increase the risk of PPCM.2-5 PPCM is underdiagnosed due to…

Keerthana Prayaga Background: Heart failure is a significant health problem in the United States affecting over 6.5 million US adults1. Many newly introduced therapeutics have not been successful past preclinical trials and survival rates have stagnated despite existing therapies1,2. Failing cardiomyocytes are characterized by decreased cardiac performance, arrhythmias, tissue necrosis,…

Andrew Hassall Background: Coronary microvascular dysfunction (CMD) is increasingly recognized as a key contributor to ischemia with non-obstructive coronary arteries, contributing to various forms of heart failure, particularly in women and individuals with diabetes or metabolic syndrome. Reduced nitric oxide (NO) bioavailability is a central feature of CMD, compromising endothelial…

Tran Vu Phuong Nguyen Background: Heart failure (HF) is a leading cause of mortality.1 Characterized by its heterogenous etiological and complex profile, HF affects millions worldwide.1 Despite its prevalence, no curative treatment for HF exists, and conventional genomics-targeted interventions have proved inadequate. Thus, there is a critical need for alternative…

Mohammad H Mustafa Background: Heart failure (HF) is a progressive clinical syndrome marked by the heart’s inability to maintain sufficient cardiac output, resulting in fatigue, dyspnea, venous congestion, and systemic hypoperfusion¹. Globally, HF affects over 26 million people and leads to an estimated $31 billion in healthcare expenditures annually¹, ².…