CD31 Analog Mediation of Pro-Reparative Macrophage Response in Aortic Dissection and Intramural Hematoma

Claire Collins Introduction: Aortic dissections and intramural hematomas (ADIM) result from tears and subsequent rupture of the walls of the aortic tunica intima and vasa vasorum, respectively.1,2 The absence of therapeutic options to rapidly induce pro-reparative effects exacerbates the size of the injury among other complications, contributing to the need…
Cardiology Engineering Medicine Immunology

Synergistic Modulation of Cerebral Edema Drainage By Central Glymphatic And Peripheral Lymphatic Systems in Post-Ischemic Stroke Patients

Urenna Orazulike Introduction: An ischemic stroke occurs when blood circulation to the brain is reduced or blocked, such that cerebral neurons are deprived of oxygen and nutrients.1 Brain edema forms soon after the onset of vascular blockage and the ensuing interruption in cerebral blood flow. Recent studies have discovered that…
Cardiology Lymphatics

IL-6 Signaling in Pulmonary Arterial Hypertension as a Potential Therapeutic Target

Michael D. Woods Introduction. Pulmonary arterial hypertension (PAH) is a rare chronic disease characterized by a mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg in the setting of pulmonary vascular disease.1 Chronic inflammation drives the endothelium and pulmonary artery smooth muscle cells (PASMC) to resist apoptosis, proliferate, and migrate, resulting…
Cardiology Featured Abstracts

Increased Understanding of MYBPC Mutations Leads to Potential Therapeutics for Patients with Familial Hypertrophic Cardiomyopathy

Jessica Saganowich Introduction: Familial hypertrophic cardiomyopathy (FHCM) is defined by having a left ventricular wall thickness greater than 15mm not due to secondary causes.1 FHCM is cuased by inherited mutations in sarcomere genes.2 The most commonly inherited mutations are in Myosin Binding Protein C (MYBPC).2 Patients with FHCM experince symptoms…
Cardiology Featured Abstracts