Category: Cardiology

Leveraging Dysfunctional Mechanisms in Familial Hypertrophic Cardiomyopathy for Therapeutic Use in Patients with MyBPC Truncation Mutations

September 5, 2023 Kieran Paddock
Kieran Paddock Introduction: Familial hypertrophic cardiomyopathy (HCM) is a genetic disease characterized by hypertrophy of the ventricular wall, causing obstruction of the left ventricular outflow tract (LVOT).1–3 It is the most common cause of sudden cardiac death in athletes.2 It is predominantly due to mutations in MYBPC3 for myosin binding…
Cardiology

Targeting Mechanisms Implicated in Irregular Calcium Handling as a Root-Cause Intervention for Ventricular Arrhythmias

July 24, 2023 Deeksha Sarda
Deeksha Sarda Background: Ventricular arrhythmias include ventricular fibrillation (VF) and ventricular tachycardia (VT) and cause up to 80% of all cases of sudden cardiac death in the United States. VT describes a two-year mortality reported to be as high as 30%[3]. In studying molecular mechanisms for arrhythmogenic phenotypes, there is…
Cardiology Engineering Medicine

Novel Treatment Strategies for Heparin-Induced Thrombocytopenia (HIT): A Review of Recent Literature

June 29, 2023 Hakam, Sarah, B.S., Hughes, Rhome, M.D.
Hakam, Sarah, B.S., Hughes, Rhome, M.D. Background: Heparin-Induced Thrombocytopenia (HIT) is an immune-mediated adverse drug reaction caused by the emergence of antibodies directed against immune complexes of heparin/anti-platelet factor 4. These antibodies activate FcγRIIa (CD32a), a low-affinity receptor for IgG expressed on platelets.1,2 Activated platelets are then consumed within thrombi,…
Cardiology Engineering Medicine

High-Sensitivity C-Reactive Protein’s Inflammatory Response as a Serum Indicator for Atherosclerotic Carotid Artery Disease

June 29, 2023 Rishik Puppala
Rishik Puppala Background:  Carotid artery disease is an atherosclerotic condition where there is lipid (LDLs mainly) and molecular buildup in vasculature. Outcomes can typically be severe and in some cases cause stroke which is the primary cause of death, dementia, and disability. Risk factors include age, men, smokers, diet, diabetes,…
Cardiology Engineering Medicine

The Role of Wall Shear Stress (WSS) in Middle Cerebral Artery (MCA) Aneurysm Development

June 29, 2023 Keyvon Rashidi
Keyvon Rashidi Background: Cerebral aneurysms (CAs) affect 2-4% of the general population, have an annual rupture rate of ~0.36%, and are associated with up to 50% mortality1,2. Unfortunately, the process of aneurysm development and rupture risk determination remains poorly understood. Similarly, no consensus exists on the appropriate time for CA…
Cardiology Engineering Medicine

Moving Past the Transplant: How Various Stem Cell Therapy Strategies are Complementing, Challenging, and Enhancing the Field of Cardiomyocyte Remuscularization after Heart Failure

June 22, 2023 Jordan Newman
Jordan Newman Background: Heart failure (HF) is the world’s leading cause of death1 and the most common diagnosis for hospital admissions over the age of 65 in developed countries.2 The permanent nature of cardiomyocytes renders cell death from HF a permanent cellular outcome with no cure. As a result, efforts…
Cardiology Featured Abstracts Stem Cells