Cardiology – Proceedings of the Texas A&M Medical Student Grand Rounds

CD31 Analog Mediation of Pro-Reparative Macrophage Response in Aortic Dissection and Intramural Hematoma

June 24, 2022 Claire Collins

Claire Collins Introduction: Aortic dissections and intramural hematomas (ADIM) result from tears and subsequent rupture of the walls of the aortic tunica intima and vasa vasorum, respectively.1,2 The absence of therapeutic options to rapidly induce pro-reparative effects exacerbates the size of the injury among other complications, contributing to the need…

Synergistic Modulation of Cerebral Edema Drainage By Central Glymphatic And Peripheral Lymphatic Systems in Post-Ischemic Stroke Patients

June 23, 2022 Urenna Orazulike

Urenna Orazulike Introduction: An ischemic stroke occurs when blood circulation to the brain is reduced or blocked, such that cerebral neurons are deprived of oxygen and nutrients.1 Brain edema forms soon after the onset of vascular blockage and the ensuing interruption in cerebral blood flow. Recent studies have discovered that…

Cardiology Lymphatics

TNF-alpha Effects on the WNK-SPAK-NCC Pathway in Salt-Sensitive Hypertension

June 23, 2022 Ethan Zinsmeister

Ethan Zinsmeister Introduction. Hypertension is a prominent disease in the United States and the world with over 45% of adults in the United States being hypertensive and hypertension being the leading cause of death and disability in the world.1,2 Salt-sensitive hypertension is a type of hypertension defined as “changes in…

Cardiology

IL-6 Signaling in Pulmonary Arterial Hypertension as a Potential Therapeutic Target

June 23, 2022 Michael D. Woods

Michael D. Woods Introduction. Pulmonary arterial hypertension (PAH) is a rare chronic disease characterized by a mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg in the setting of pulmonary vascular disease.1 Chronic inflammation drives the endothelium and pulmonary artery smooth muscle cells (PASMC) to resist apoptosis, proliferate, and migrate, resulting…

Cardiology Featured Abstracts

Methods of Intervention in Cardiac Hypertrophy with a Focus on M6a Methylation

June 22, 2022 Jeswin Vennatt

Jeswin Vennatt Introduction. When the heart undergoes stress stimulation such as a myocardial infarction or pressure overload, it undergoes hypertrophic growth.1 This initial cardiac remodeling is so that the heart can match the increase in stress, however, it is also the primary reason for heart failure.1 Cardiac hypertrophy is heavily…

Cardiology

Using Allele-Specific RNA Silencing of MYH7 to Treat Hypertrophic Cardiomyopathy

June 21, 2022 Kade Scoresby

Kade Scoresby Introduction. Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiomyopathy, affecting about 1 in 500 people.1 HCM is genetically inherited, with mutations in the MYH7 (β-myosin heavy chain protein) and MYBPC3 (myosin-binding protein C) genes accounting for approximately 70% of HCM cases.2,3 The most common HCM treatments include…

Cardiology

CCR5 Inhibition After Stroke Improves Motor and Cognitive Function through Enhanced CREB/DLK Signaling

June 21, 2022 Kiran Sankarappan

Kiran Sankarappan Introduction. Stroke is the fifth leading cause of death and a leading cause of disability in the United States, affecting 800,000 individuals annually.2 The brain is a notable utilizer of oxygen and stroke occurs when an obstruction of an artery prevents blood and oxygen from reaching a certain…

Cardiology Featured Abstracts

Increased Understanding of MYBPC Mutations Leads to Potential Therapeutics for Patients with Familial Hypertrophic Cardiomyopathy

June 21, 2022 Jessica Saganowich

Jessica Saganowich Introduction: Familial hypertrophic cardiomyopathy (FHCM) is defined by having a left ventricular wall thickness greater than 15mm not due to secondary causes.1 FHCM is cuased by inherited mutations in sarcomere genes.2 The most commonly inherited mutations are in Myosin Binding Protein C (MYBPC).2 Patients with FHCM experince symptoms…

Cardiology Featured Abstracts

The Cardio-Protective Role of the Clock Gene Following Myocardial Infarction

June 21, 2022 Daniaal Saeed

Daniaal Saeed Introduction: Myocardial infarction (MI) results from prolonged ischemia to the myocardium of the heart caused by stenosis of the coronary arteries that perfuse the heart.1,2 Despite the fact that MI is an acute event, many long-term lifestyle factors such as environment, diet, genetics, exercise habits, and even gender…

Cardiology Circadian Rhythms

: The role of Isolevuglandins and Pro-Inflammatory Cytokines on Antigen Presenting Cell-Induced Hypertension

June 21, 2022 Shahbaz Saad

Shahbaz Saad Introduction: Hypertension is a condition that affects over 1 billion people.2 It is a leading cause of death worldwide. Hypertension is defined by systolic blood pressure being greater than 140 mm Hg and diastolic blood pressure being > 90 mm Hg9,10 Men are generally more affected than women,…

Cardiology Immunology Inflammation