METTL3 Methyltransferase on m6A mRNA in Cardiomyocytes

Otitodilichukwu Ojukwu Introduction. Heart disease is the leading cause of death in the United States. Heart disease presents itself in many forms clinically and is apparent in many patient populations. Heart failure is a progressive disease that occurs after multiple ischemic and traumatic events to the cardiac tissue. Several studies…
Cardiology

The Role of Optical, Acoustic, and Human Dependent Technologies In Monitoring Vascular Perfusion After Free Flap Tissue Transfers in Reconstructive Surgery

Raghave Upadhyaya Introduction. Free tissue transfer flaps, or commonly referred to as free flaps, are portions of tissue that can be dissected away from its anatomical location, due to its own unique arterial and venous blood supply,and transplanted into its non anatomical position in the case of injury1. The free…
Cardiology Engineering Medicine

miR-21 Inhibition Reduces Cardiac Fibrosis and Improves Cardiac Function After Acute Myocardial Infarction in Pig

Carmen Fitzpatrick Introduction. Cardiac fibrosis primarily occurs after an acute myocardial infarction due to an aberrant innate inflammatory and repair response. Often, the fibrotic repair response contributes to early onset heart failure which leads to a rapidly declining quality of life. Current therapeutic methods lack appropriate prevention of the overzealous…
Cardiology

The Role of Cardiomyocyte Mitochondrial AMPK and ATP Synthase in Hypertrophic Cardiomyopathy (HCM)

Divek Toprani Introduction. Hypertrophic Cardiomyopathy (HCM) is a cardiovascular disease affecting 1 in 500 people where heart muscle becomes abnormally thick.1 HCM can manifest as a left ventricular outflow tract obstruction, left ventricular hypertrophy, or a non-obstructive form with wall thinning and dilation of the cavity.1 HCM is characterized by…
Cardiology Engineering Medicine Featured Abstracts

Impact of B-adrenergic Receptors in the Development, Diagnosis and Treatment of Takotsubo Cardiomyopathy

Paulamy Ganguly Introduction: The etiology of takotsubo cardiomyopathy (TCM) is poorly understood, yet the increased concentration of catecholamines is most often implicated in disease pathophysiology(1). Under stressful conditions, influx of catecholamines stimulates B-adrenergic receptors which leads to cardiomyocyte necrosis and toxicity(1). Patients with TCM present with chest pain, dyspnea or…
Cardiology Engineering Medicine Featured Abstracts

Ferritin H’s Role in Iron-related Molecular Pathways Leading to Congestive Heart Failure Predisposition

Charles Foster Introduction. Congestive heart failure (CHF) is a common cardiopulmonary condition that is characterized by decreased cardiac output, particularly with reduced ejection fraction. CHF is one of the most prevalent causes of respiratory failure in the adult U.S. population.1 Diagnosis of CHF often cannot be made by physical exam…
Cardiology Engineering Medicine