Herpes simplex virus type 1 contributes to Alzheimer’s disease by preventing regulation of formation and destruction of Aβ amyloid plaques.

Candice Hill Introduction. Over 25 million people in the world are affected by dementia, most suffering from Alzheimer’s Disease (AD), a progressive neurodegenerative disease caused by an accumulation of Aβ amyloid3. However, what triggers this Aβ accumulation has yet to be clearly defined. In this commentary, herpes simplex virus type…
Featured Abstracts Microbiology Neuroscience

The Effect of Dietary Products in Combination with Gut Microbes That Enable Localized Generation of SCFA on Histone Modifications and the Pathogenesis of Colon Cancer

Michael Buchholz Introduction. Colorectal cancer (CRC) is the 3rd most common cause of cancer worldwide, with a 10x higher incidence in Western countries1. CRC is, however, increasing in some Asian countries as they shift to a Western diet2. A high fiber diet (HFD) is associated with decreased incidence of CRC3.…
Cancer Microbiology

Propionic Acid Metabolite of Gut Microbiome Implicated in the Pathogenesis of Autism Spectrum Disorder

Chad Griesbach Introduction. Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by social deficits, repetitive behaviors, and restricted interests. The prevalence of ASD has dramatically increased recently, rising from 4.5 in 10,000 in 1966, to 1 in 68 children aged eight years in 20106. Gastrointestinal comorbidities are common…
Microbiology Neuroscience

The Role of Non Structural Protein 4A of Zika Virus in Suppressing the Akt-mTOR Pathway in Neural Stem Cells

Hannakate Hall Introduction: Zika Virus is a positive sense, single stranded RNA flavivirus that has attracted worldwide attention within the last 5 years for its transcontinental spread and ability to evoke devastating results within certain patient populations1. Zika is transmitted by the bite of infected Aedes aegypti mosquitoes6, and is…
Microbiology Neuroscience Stem Cells

The Role of Obesity-Induced Lipoteichoic Acid, Lipopolysaccharide, and Deoxycholic Acid Microbiota Components in Hepatocellular Carcinoma Development

Aishwarya Buvanendiran Introduction. Hepatocellular Carcinoma (HCC), a form of liver cancer where chronic liver disease leads to uncontrolled proliferation of adult hepatocytes1, mostly occurs in males over the age of 502 and develops poor prognosis characterized by portal hypertension, hepatic encephalopathy, and fatal cardiovascular complications1,3,4. Relative risks for developing liver…
Cancer Microbiology

Propionic Acid Metabolite of Gut Microbiome Implicated in the Pathogenesis of Autism Spectrum Disorder

Chad Griesbach Introduction. Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by social deficits, repetitive behaviors, and restricted interests. The prevalence of ASD has dramatically increased recently, rising from 4.5 in 10,000 in 1966, to 1 in 68 children aged eight years in 20106. Gastrointestinal comorbidities are common…
Microbiology Neuroscience

Potential role of fermentative microbial metabolites butyrate and propionate as targets in gut microbiome-based therapeutics for subtypes of autism spectrum disorder

Vincent Provasek Introduction Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder affecting millions in the US. Recent data have noted a steady increase in the prevalence of ASD, with up to 1-2.5% of US children and adolescents being affected1-3. While the exact etiology of ASD remains unclear, ASD is…
Microbiology Neuroscience

The Role of Probiotics in the Use of Treatment for Autism Spectrum Disorder to Correct Intestinal Permeability and Behavior Abnormalities

Truce Pham Introduction: Autism Spectrum Disorder (ASD) is a severe neurodevelopmental disorder that affects an individual’s communication and interaction skills with an incidence of 1 in 59 in 20141,2. Because many causative factors have been attributed to ASD and none being a leading cause, there is no agreed upon treatment3.…
Microbiology Neuroscience