Mechanical Load-Induced Articular Collagen Remodeling as a Potential Therapeutic Target for Rheumatoid Arthritis

Alexandra Ramos Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease affecting joints. Women are twice as likely to develop RA, and increasing age is another risk factor1. RA has a multifactorial etiology but is characterized by autoantibodies that target citrullinated proteins, leading to inflammatory cells infiltrating and secreting…
Engineering Medicine Immunology Inflammation Orthopedics

Targeting Serum Cytokines as Prognostic Biomarkers for COVID-19 Biosensors

Shourya Kumar and Limei Tian, PhD Introduction: Coronaviruses are enveloped RNA viruses in humans and animals that can cause acute and chronic diseases1. In patients with a weak immune system or other (unknown) pre-existing conditions, an uncontrolled inflammatory response linked to a cytokine storm has been associated with severe pulmonary…
Engineering Medicine Immunology Inflammation Microbiology

Cellular Senescence Is Associated with Phenotypic Changes that Promote Inflammation and Aging

Emily Lo Introduction: Cellular senescence is a cell stage associated with DNA damage in which a cell can no longer replicate and gains resistance to apoptosis1. Senescent cells secrete an array of inflammatory cytokines and chemokines, including TNF-alpha, IL-6, and IL-81. Accumulation of senescent cells and their associated inflammation is…
Aging Engineering Medicine Featured Abstracts Inflammation

Elevated Proinflammatory Cytokines in Patients with Depression

Elizabeth Bixler Introduction: Major Depressive Disorder (depression) is a mood disorder thought to be driven by neurotransmitter imbalance. It is the leading cause of disability worldwide1, and in any given year, 17.3 million Americans suffer from depression2. Many groups have studied the link between elevated proinflammatory cytokines and depression and…
Engineering Medicine Inflammation Psychiatry

The Role of Biogenetics for PRP Injections in Lateral Epicondylitis

Krishna Anand Introduction. Lateral epicondylitis (LE) is caused by the overuse of the wrist extensors, typically from repetitive movements with the forearm in the pronated position1. Treatment options for patients with aggravating and persistent LE are limited non-operatively1. Current modalities of treatment include non-steroidal anti-inflammatory drugs, corticosteroid injections, and physical…
Engineering Medicine Inflammation Orthopedics

The Role of COX-2 And PGE2 in the Promotion of Neuroinflammation and Deposition of beta-Amyloid Protein in Alzheimer’s Disease

Chloe Todd Introduction: Alzheimer’s disease (AD) is the leading cause of dementia, projected to affect 150 million people worldwide by 2050.1 Current treatment focuses on improving patients’ symptoms; pharmacological therapy does not yet address disease pathology.2 AD pathogenesis begins with aggregation of β-amyloid (Aβ) protein in the brain.1 Amyloid precursor…
Featured Abstracts Inflammation Neuroscience

The Regulation of Macrophage Polarization through Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Osteoarthritis

Aniruth Srinivasaraghavan Introduction: Osteoarthritis (OA) is the irreversible degeneration and dysfunction of articular cartilage and adjacent tissues that eventually leads to joint destructions1,2. Non-pharmacological treatment such as exercise, weight loss, as walking aids as indicated are recommended for first line of treatment. Exercise therapy is recommended for helping to decrease…
Immunology Inflammation Orthopedics