Daniyaal Qazi  Background: Traumatic spinal cord injury (SCI) is a major cause of permanent neurological disability, affecting approximately 20.6 million individuals globally as of 2019, with an annual incidence of 0.9 million new cases.1 The primary mechanical insult triggers a progressive secondary injury cascade leading to ischemia, glutamate excitotoxicity, oxidative…

Ethan A. Noyola Background: By broadly suppressing inflammatory gene programs through the intracellular glucocorticoid receptor (GR), glucocorticoids remain among the most clinically powerful anti-inflammatory drugs available.¹,² Glucocorticoids delay disease progression and prolong ambulation, but not without a cost as chronic exposure contributes to growth suppression, muscle wasting, osteoporosis, metabolic dysregulation,…

Zahi Hussain Background: Diabetic retinopathy (DR) and ischemic retinopathy are among the most common causes of irreversible vision loss worldwide. Current standard-of-care treatments, including anti-VEGF therapy and surgical intervention, target late-stage disease manifestations and fail to address the neuroinflammatory and neurodegenerative processes that begin much earlier in disease progression.1,5 Necroptosis…