Category: Inflammation

Inflammatory Response and Regulation of T-lymphocytes Involved in Cardiac Remodeling Impacting the Severity of Ischemic Cardiomyopathy

June 21, 2023 Katelyn Rook
Katelyn Rook Background: Ischemic heart diseases cause an estimated 17.9 million deaths annually, with most of these cases involving myocardial infarction (MI) of left ventricular (LV) cardiac tissue1. Following an acute MI, the immune system coordinates an inflammatory response to clear damaged tissue and promote wound healing2. As a result…
Cardiology Immunology Inflammation

Intranasal Administration of Stem Cell-Derived Extracellular Vesicles inhibits the Neuroinflammatory Cascade After Traumatic Brain Injury

June 21, 2023 Minh-Nguyet Hoang
Minh-Nguyet Hoang Background: Traumatic brain injury (TBI) is a multifactorial condition caused by an external mechanical force that can lead to various neurological impairments, including physical, psychological, and cognitive functions1,3,4. TBIs represent the third most common cause of mortality worldwide, with an increased risk in the elderly, athletes, and low…
Featured Abstracts Inflammation Neuroscience

T-Cell Imbalance and Inflammatory Cytokines as Potential Drug Targets for the Treatment of Myasthenia Gravis

June 20, 2023 Alec J Monhollen
Alec J Monhollen Background: Myasthenia gravis is an autoimmune disorder against post-synaptic proteins in the neuromuscular junction, including the acetylcholine receptor and muscle-specific kinase.1,2  Symptoms can include general muscle weakness, ptosis, diplopia, and dysarthria.1,3 The current standard treatments are acetylcholinesterase inhibitors which function to increase the amount of acetylcholine in…
Featured Abstracts Immunology Inflammation Neuroscience

An Application of Mesenchymal Stem Cell-derived Extracellular Vesicles in the Reduction of Proinflammatory Signaling via Delivery of miRNA-126 in the Progression of Diabetic Retinopathy

June 20, 2023 Abigail Hawkins
Abigail Hawkins  Background: Diabetic retinopathy is the primary ocular complication of uncontrolled diabetes mellitus and a chief cause of visual loss in the elderly.1 Pathogenesis is characterized by pro-inflammatory signaling, via markers such as high mobility group box 1 (HMGB1), and oxidative stress, resulting in breakdown of the blood-retinal barrier…
Endocrinology Featured Abstracts Inflammation

The Therapeutic Effects of Exosomes Derived From Human Adipose Tissue-Derived Mesenchymal Stem Cells in Alleviating Atopic Dermatitis By Reducing Type 2 Helper T Cell Induction

June 6, 2023 Anna (Seo Won) Cho
Anna (Seo Won) Cho Background: Atopic dermatitis (AD) is an inflammatory skin condition characterized by pruritus and cutaneous lesions with a 10% lifetime prevalence.1 Th1 and Th2 cells are upregulated in AD in which Th1 cells activate delayed hypersensitivity reactions while Th2 cells induce B cells to produce IgE antibody…
Featured Abstracts Immunology Inflammation

Natural approach to reestablish Th17/Treg balance to treat inflammatory bowel disease by activating the SCFA-PPARγ Axis in Colitis

June 5, 2023 Abigail Munteanu
Abigail Munteanu Background: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract. The cause of IBD remains unknown, however, because of the disease’s higher prevalence in more developed countries, it is believed that food intake plays an important role. This is based on the interaction of the…
Featured Abstracts Immunology Inflammation

Epstein-Barr Virus And Its Association With Multiple Sclerosis Via Autoreactive B-Cell And Defective Cytotoxic T-Cells

June 5, 2023 Zachary Payne
Zachary Payne Background: Multiple Sclerosis (MS) is a neurological disease affecting myelinated nerves of the central nervous system (CNS).1 The destruction of myelin of nerve axons in the disease leads to a variety of CNS symptoms.1-5 Important factors which increase risk for MS include being female, smoking, obesity, and Vitamin…
Featured Abstracts Immunology Inflammation Microbiology

Mechanical Load-Induced Articular Collagen Remodeling as a Potential Therapeutic Target for Rheumatoid Arthritis

June 28, 2022 Alexandra Ramos
Alexandra Ramos Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease affecting joints. Women are twice as likely to develop RA, and increasing age is another risk factor1. RA has a multifactorial etiology but is characterized by autoantibodies that target citrullinated proteins, leading to inflammatory cells infiltrating and secreting…
Engineering Medicine Immunology Inflammation Orthopedics