Green Tea Extract Dietary Therapy Protection Against Dysbiotic Microbiota Induced Metabolic Endotoxemia through Increased Intestinal Barrier Function, Decreased Endotoxin Translocation, and Decreased Chronic Inflammation

Sreeya Cherlo Introduction. Dysbiosis, an imbalance in the gut microbial community, and consequent lymphatic inflammation are associated with the development of a multitude of diseases.1 Metabolic Endotoxemia is caused by the presence of endotoxins in the blood which are derived from gram-negative bacteria included in dysbiotic gut microbiota.1 The translocation…
Inflammation Microbiology

Innate Immunity Inflammation: A Possible Cause of Postoperative Cognitive Dysfunction (POCD) and a Therapeutic Option

Cesar Carpio  Introduction: At the time of discharge it is reported that 41.4% of patients 60 years or older are subjected to Postoperative Cognitive Dysfunction (POCD) after noncardiac surgery.1 Clinical findings of POCD include disturbance of learning, memory, and processing of information even years post-surgery/anesthesia.2 Although rodent models seem to…
Inflammation Neuroscience

Rapid Healing: Accelerating Chronic Diabetic Wound Repair Via Setdb2 and NF-κB Modulation of Macrophage Polarization During Inflammation

Ahad Azimuddin  Introduction. Chronic diabetic wounds (CDWs) present a significant physical and financial burden on our society. More than 6.5 million Americans suffer from non-healing wounds, costing $35.3 billion to Medicare.1 Pathologic wound repair disrupts any of the four stages of physiologic wound repair: hemostasis, inflammation, proliferation/repair, and remodeling.1,2 In the…
Immunology Inflammation

The role of short chain fatty acids in alleviating anxiety by reducing gut corticotropin releasing factor receptor (CRFR) expression and systemic inflammation

Lena Ayari Introduction. Generalized anxiety disorder (GAD) is one of the top causes of mental illness in the U.S., affecting around 3.1% of the population.1 Current pharmaceutical therapies are associated with unpleasant and potentially harmful side effects, and only around 45-55% of those affected achieve remission following treatment.1,2 Studies have…
Endocrinology Featured Abstracts Inflammation Neuroscience

The Role of Gut Microbiota Metabolites in Modulating the Inflammatory Effects Leading to Atopic Dermatitis

Hope Allen Introduction. Atopic Dermatitis (AD) is a chronic inflammatory skin disease with causal links ranging from a dysregulated immune response, genetic factors, and the environment.1 AD is diagnosed by the presence of itching, epidermal barrier dysfunction, lesions with increased T-helper 2 (Th2) cells, mast cells, eosinophils, and increased IgE…
Immunology Inflammation

Mechanisms Regulating Th17 T Cells Implicated in the Pathogenesis of Autoimmune Conditions Like Arthritis

Jacob Moser Introduction. Many chronic inflammatory diseases like asthma, rheumatoid arthritis, and many others owe their pathogenicity to ‘typical’ inflammatory cytokines like TNFa, and can be targeted clinically by widely used drugs like Adalimumab (Humira). But recently discovered types of asthma, rheumatoid arthritis, and others that did not respond adequately…
Featured Abstracts Immunology Inflammation

The Impact of Ethanol Abuse on Cognitive Function in Adolescence due to Neuroinflammation from the Innate Immune System: The Role of Toll-Like Receptor 4

Peter Nguyen Introduction. Alcohol Use Disorders (AUDs) are one of the main risk factors for disease that account for 6-9% of mental, neurological, and substance abuse disorders.1 It has been discovered that ethanol abuse can lead to sustained neuroinflammation due to the response of the innate immune system via Toll-Like…
Inflammation Neuroscience

Assessing Endotypes of Asthma Including IL-33 and IRAK-1 (IL-R-Associated Kinase)

Jonathan Lutgens Introduction. Asthma is a complex disease associated with airway inflammation, mucus hypersecretion, and bronchoconstriction1. In older literature, asthma was seen as simply an IgE-mast cell mediated response. However, recent studies have had a greater focus on the different endotypes (subtypes) of asthma. This is significant because future treatment…
Featured Abstracts Inflammation Respiratory