Role of Matrix Metalloproteases (MMP) Inhibitors in Decreasing Permeability of the Blood-Brain Barrier and Modulation of Inflammatory Response during Ischemic Stroke

Ashmi Patel Introduction. Stroke outco me is dependent on several factors including the permeability of the blood-brain barrier (BBB) by matrix metalloproteases (MMPs).2  In ischemia, MMP-2 and MMP-9 degrade claudin-5, which facilitates the increased permeability of the BBB and decrease in tight junction proteins (TJPs).2  MMP-9 cleaves ZO-1 and degrades…
Cardiology Inflammation

The Role of T-Regulatory Cells on the Development of Systemic Lupus Erythematosus

Peter Lin Introduction. Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease in which circulating autoantibodies and immune complexes deposit, activating the compliment system and causing local inflammation and tissue destruction throughout the body1-2. SLE usually starts in late childhood to young adulthood, predominantly affecting females in reproductive years3. Dysfunction…
Immunology Inflammation

The Role of NF-kB in Vascular Inflammation in Pre-eclampsia Through Down Regulation of eNOS at the Post-transcriptional Level via miRNA Expression

Nastassia Pham Introduction. Pre-eclampsia is a pregnancy induced hypertensive disorder characterized by systolic blood pressure greater than 140 mmHg and diastolic blood pressure greater than 90 mmHg that usually presents after 20 weeks of gestation1,2. The pathology begins with malfunction during trophoblast invasion, resulting in reduced uteroplacental perfusion1. This stresses…
Cardiology Inflammation

The Role of H. pylori in the Progression of Gastric Cancer Through Activation of the JAK/STAT Pathway and Sequential Inflammatory Response Elements

Sanjana Nayak Introduction. Gastric cancer is one of the leading causes of cancer-related death in the world, with the rate of incidence still high in East Asia1. H. pylori infection is the main risk factor, with the likelihood for infection increasing with greater age, higher BMI, and male sex2,3,4. H.…
Cancer Inflammation Microbiology

The Role of Mast Cell-Mediated Inflammation on IBS-Induced Abdominal Pain

Pavia Ann Muringathuparambil Introduction: IBS is a gastrointestinal disease triggered by many factors. Symptoms vary greatly between patients, but abdominal pain and bloating are most common. While a specific cause has yet to be identified, many factors including gene mutations1,2, gut microbiome imbalances3, and mast cell hyperplasia4 are being investigated…
Inflammation Microbiology

Use of Synovium-Derived Mesenchymal Stem Cells to Form Scaffold-Free Tissue Engineered Construct to Promote Repair of Knee Chondral Lesions to Prevent Development of Osteoarthritis

Victoria Hamilton  Introduction: Osteoarthritis (OA) is the most common joint disorder in the world (global prevalence 3.8%) and significantly contributes to disability globally.1–3 OA of the knee (KOA) has the highest incidence in the body, with a lifetime risk of approximately 45%.3 Mesenchymal stem cells (MSCs) are heterogenous stem cells…
Featured Abstracts Inflammation Orthopedics Stem Cells