Category: Stem Cells

Mesenchymal Stem Cells (MSCs) and MSC-Derivatives for Improving Outcomes with Sepsis-Induced Acute Respiratory Distress Syndrome

August 4, 2025 Ivan Rodriguez-Oliveros
Ivan Rodriguez-Oliveros Background: Acute Respiratory Distress Syndrome (ARDS) is characterized by alveolar capillary damage that leads to inflammation and pulmonary edema.1 The tissue injury causes a decrease in lung compliance, requiring patients to be mechanically ventilated. Approximately 23% of all ventilated patients are those with ARDS.1 ARDS, classified through the…
Engineering Medicine Featured Abstracts Respiratory Stem Cells

Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorate Rheumatoid Arthritis by Modulating the Th17/Treg Balance

July 18, 2025 Jonathan Joseph
Jonathan Joseph Background:  Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by joint stiffness, swelling, and pain, affecting approximately 1% of the global population 1. While genetic factors like the HLA-DRB1 allele contribute to RA, environmental triggers such as smoking and obesity play a significant role, as evidenced by…
Featured Abstracts Immunology Stem Cells

Stem Cells and Skin Regeneration in Burn Wounds

July 17, 2025 Cason Dudney
Cason Dudney Background:  Burn wounds represent a significant clinical challenge due to their complexity, high morbidity, and long-term disability. Traditional therapies often fall short in addressing the extensive tissue loss and impaired healing in severe burns. Recent advances in regenerative medicine have highlighted the potential of stem cell-based therapies in…
Stem Cells Wound Healing

Mesenchymal Stem Cells Used for Their Anti-Inflammatory and Immunomodulatory Properties to Treat and Hinder Progression of Osteoarthritis

May 30, 2024 Ryan James
Ryan James Background:  Osteoarthritis (OA) is the most common degenerative disease seen in the world, with women being up to 40% more likely to develop the disease.1 The activation of cytokines and matrix metalloproteinases (MMPs) are directly responsible for the destruction of cartilage tissue in OA.1,2 In OA, proinflammatory cytokines…
Featured Abstracts Inflammation Orthopedics Stem Cells

Stem Cell Therapy for Pulmonary Fibrosis

May 30, 2024 Hailey Hunt
Hailey Hunt Background: Idiopathic pulmonary fibrosis (IPF) is an irreversible, progressive interstitial lung disease with minimal available treatments and poor prognosis yielding an average life expectancy of 3-5 years after diagnosis. 1,2 IPF is characterized by the persistence of profibrotic growth factors resulting in excessive deposition of collagen in the…
Featured Abstracts Inflammation Stem Cells

The Therapeutic Applications of Mesenchymal Stem Cell Therapy in Systemic Lupus Erythematosus

May 30, 2024 Ashley Cullum
Ashley Cullum Background: Systemic Lupus Erythematosus (SLE) occurs when the body’s immune system erroneously targets its own tissues, causing widespread inflammation and tissue damage systemically. Central to SLE pathogenesis are dysregulated protein kinase pathways, precipitating proliferation of T cells, particularly CD4+ T cells, which promote a cascade of pro-inflammatory cytokines,…
Inflammation Stem Cells

Moving Past the Transplant: How Various Stem Cell Therapy Strategies are Complementing, Challenging, and Enhancing the Field of Cardiomyocyte Remuscularization after Heart Failure

June 22, 2023 Jordan Newman
Jordan Newman Background: Heart failure (HF) is the world’s leading cause of death1 and the most common diagnosis for hospital admissions over the age of 65 in developed countries.2 The permanent nature of cardiomyocytes renders cell death from HF a permanent cellular outcome with no cure. As a result, efforts…
Cardiology Featured Abstracts Stem Cells