Category: Stem Cells

Stem-Cell Derived: Extracellular Vesicles as a Novel Therapeutic for Alzheimer’s Disease

July 13, 2026 Nidhi Shah
Nidhi Shah Background: Alzheimer’s disease (AD) is a complex, multifactorial neurodegenerative disorder driven by aging, genetic predispositions, and systemic molecular dysregulation.4 The traditional pathogenic model highlights the extracellular deposition of amyloid-beta (Aβ) plaques and intracellular hyperphosphorylated tau tangles.4,5 However, disease progression also involves chronic neuroinflammation mediated by microglia and severe…
Neuroscience Stem Cells

Evaluation of Maternal IL-6 Transport via Placenta-on-a-Chip: Mechanistic Implications for Fetal Neural Stem Cell Dysregulation and Neurodevelopmental Risk

July 3, 2026 Anthony Vitale
Anthony Vitale Background: Maternal immune activation (MIA), often triggered by infection or severe inflammatory stress during pregnancy, is an established environmental risk factor for neurodevelopmental disorders in offspring, including autism spectrum disorder (ASD) and schizophrenia.¹˒² Interleukin-6 (IL-6) has emerged as a central mediator of this process, capable of altering placental…
Stem Cells

Engineering Mesenchymal Stem Cell-Derived Exosomal miRNA Cargo to Restore Angiogenesis in Diabetic Foot Ulcers

July 3, 2026 Sri Tummala
Sri Tummala Background: Diabetic foot ulcers (DFU) are chronic, treatment-refractory wounds that develop in 15–25% of patients with diabetes during their lifetime and remain the leading cause of non-traumatic lower-extremity amputation.1 Healing fails because chronic hyperglycemia suppresses PI3K/AKT, eNOS, and VEGF angiogenic signaling, sustains pro-inflammatory cytokines such as TNF-α and…
Diabetes Featured Abstracts Stem Cells

Radiation-induced Mesenchymal Stem Cell Dysfunction Links Mechanistic Injury to Emerging Regenerative Therapies

July 2, 2026 Thomas Noonan
Thomas Noonan Background: Radiation therapy is an important part of cancer treatments; however, it often leaves bone with long term damage that is difficult to repair.  Patients develop associated bone loss, delays in the healing time of a fracture, and even osteoradionecrosis in regions previously irradiated. Current treatments focus on…
Featured Abstracts Stem Cells

A Novel Circular RNA-Mediated Regulatory Axis Driving the Malignant Transformation of Mesenchymal Stem Cells in Osteosarcoma

July 2, 2026 Yash Narsian
Yash Narsian Background: Osteosarcoma (OS) is the most common malignancy of the bone with the highest incidences in 18- & 60-year-olds. OS originates from aberrant mesenchymal stem cells.1 In the 1980s, multiagent chemotherapy as standard treatment improved 5-year survival rates from ~20% to ~60%. However, since then, there has been…
Cancer Featured Abstracts Stem Cells

Neural Stem Cell-Derived Extracellular Vesicles Protect Neurons from Amyloid-Beta Toxicity in Alzheimer’s Disease

July 1, 2026 Yahya Kharbat
Yahya Kharbat Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting ~7.2 million Americans aged 65 and older, with projections reaching 12.7 million by 2050 and annual care costs exceeding $360 billion.1 The disease is defined by two pathological hallmarks: amyloid-beta (Aβ) plaques and neurofibrillary tau tangles. Among toxic…
Neuroscience Stem Cells

Stem Cell Plasticity as a Driver of Colorectal Cancer Metastasis and Therapeutic Resistance

July 1, 2026 Thompson Hui
Thompson Hui Background: Colorectal cancer (CRC) remains a leading cause of cancer morbidity and mortality worldwide, with metastatic disease accounting for the majority of CRC-related deaths.1,2 Although surgery, chemotherapy, targeted therapy, and immunotherapy have improved survival, metastatic CRC frequently recurs or develops treatment resistance.3 Recent research suggests that these failures…
Cancer Stem Cells

Strategies to Enhance the Therapeutic Efficacy of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Autoimmune Uveitis

July 1, 2026 Grace Hamadeh
Grace Hamadeh Background: Autoimmune uveitis is a chronic immune-mediated inflammatory disease of the eye and a major cause of preventable vision loss in working-age populations. Recurrent intraocular inflammation leads to progressive retinal damage and irreversible visual impairment. Current therapies, including corticosteroids and systemic immunosuppressants, primarily suppress inflammation but fail to…
Inflammation Stem Cells

Mesenchymal Stem Cells (MSCs) and MSC-Derivatives for Improving Outcomes with Sepsis-Induced Acute Respiratory Distress Syndrome

August 4, 2025 Ivan Rodriguez-Oliveros
Ivan Rodriguez-Oliveros Background: Acute Respiratory Distress Syndrome (ARDS) is characterized by alveolar capillary damage that leads to inflammation and pulmonary edema.1 The tissue injury causes a decrease in lung compliance, requiring patients to be mechanically ventilated. Approximately 23% of all ventilated patients are those with ARDS.1 ARDS, classified through the…
Engineering Medicine Featured Abstracts Respiratory Stem Cells

Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorate Rheumatoid Arthritis by Modulating the Th17/Treg Balance

July 18, 2025 Jonathan Joseph
Jonathan Joseph Background:  Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by joint stiffness, swelling, and pain, affecting approximately 1% of the global population 1. While genetic factors like the HLA-DRB1 allele contribute to RA, environmental triggers such as smoking and obesity play a significant role, as evidenced by…
Featured Abstracts Immunology Stem Cells