Category: Stem Cells

Moving Past the Transplant: How Various Stem Cell Therapy Strategies are Complementing, Challenging, and Enhancing the Field of Cardiomyocyte Remuscularization after Heart Failure

June 22, 2023 Jordan Newman
Jordan Newman Background: Heart failure (HF) is the world’s leading cause of death1 and the most common diagnosis for hospital admissions over the age of 65 in developed countries.2 The permanent nature of cardiomyocytes renders cell death from HF a permanent cellular outcome with no cure. As a result, efforts…
Cardiology Featured Abstracts Stem Cells

Utilization of Mesenchymal Stem Cells for Treatment of Disc Degeneration by Modulation of the WNT Signaling Pathway

June 22, 2023 Val Lumani
Val Lumani Background:  Intervertebral disc degeneration is a leading cause of back pain worldwide2. Its underlying molecular mechanisms consists of a myriad of pathways, one of the main ones being degeneration of the nucleus pulposus and it’s extracellular matrix2. The nucleus pulposus (NP) consists of type II collagen and proteoglycans,…
Neuroscience Orthopedics Stem Cells

Osteoarthritis Treatment: The Role of the WNT and BMP Pathways in Chondrogenic Differentiation of Mesenchymal Stem Cells

June 21, 2023 Jerry Liu
Jerry Liu Background: Osteoarthritis is the most prevalent chronic joint disease3, and is a leading cause of disability in older adults.1 OA involves the entire joint and works by causing articular cartilage loss.3 Pain, along with loss of range of motion, are both major symptoms of osteoarthritis.1,2 First-line treatment involves…
Featured Abstracts Orthopedics Stem Cells

Mesenchymal Stem Cells as a Treatment for Acute Respiratory Distress Syndrome

June 24, 2022 Michael Biskup
Michael Biskup Introduction. Acute Respiratory Distress Syndrome (ARDS) is an inflammatory reaction of the lungs to cellular damage. ARDS commonly develops after trauma, infection, pleuritis, and aspiration. Hypoxemic respiratory failure is a defining characteristic. In the beginning stages of ARDS, the body releases inflammatory mediators such as IL-1. Neutrophils then…
Engineering Medicine Respiratory Stem Cells

Tumorigenic Remodeling of Intestinal Stem Cell Crypts and its Therapeutic Potential in Familial Adenomatous Polyposis

June 20, 2022 Joshua Nedelisky
Joshua Nedelisky Introduction. Familial adenomatous polyposis (FAP) is an autosomal dominant disease resulting from a germline mutation within the adenomatous polyposis coli (APC) gene.1,2 APC loss results in dysregulated cell proliferation via constitutive activation of the WNT/β-catenin signaling, causing prolific intestinal polyp expression and a definitive lifetime risk of colorectal…
Cancer Stem Cells

Mesenchymal Stem Cell Extracellular Vesicles Improve Achilles Tendon Healing Through Modulation of the M1/M2 Macrophage Ratio

June 16, 2022 Daniel Lindahl
Daniel Lindahl Introduction: Achilles tendon ruptures are extremely prevalent in both athletes and the general populace, accounting for 20% of all large tendon ruptures.1 Both surgical and non-surgical treatment are aimed at approximating tendon edges to promote healing, however re-rupture rates remain high due to unresolved inflammation.1,2 Macrophages play a…
Immunology Orthopedics Stem Cells

Novel 2D Beta Cell Differentiation Method Promotes Mature Beta Cell Differentiation from Induced Pluripotent Stem Cells by Controlling Cytoskeletal Polymerization States with Latrunculin A to Restore Normoglycemia to Diabetic Mice

June 12, 2022 Andrew Krueger
Andrew Krueger Introduction: Type 1 diabetes occurs when the body’s immune system attacks its own beta cells due to a variety of environmental and genetic causes that are yet to be fully understood1, 2. The result is complete destruction of the beta cells and eventually complete insulin insufficiency and dependance…
Endocrinology Stem Cells

Mechanical Vibration Induces Differentiation of Mesenchymal Stem Cells to Osteoblasts at the Expense of Adipocyte Differentiation through Activation of Wnt Pathway and Inhibition of PPARgamma Nuclear Hormone Receptor in Osteoporotic Bone

May 31, 2022 Dakota Doucet
Dakota Doucet Introduction. Osteoporosis (OP) in post-menopausal women causes abnormally low bone mineral density, bone fragility, and high bone marrow adipocyte content. With 54 million currently afflicted in the United States and another 120 million predicted to suffer from OP by 2050 in China1, substantial efforts have been directed towards…
Orthopedics Stem Cells