Using Deferoxamine to Improve Soft Tissue Regeneration following Achilles Tendon Repair

Will Singer Introduction. The Achilles tendon is the strongest tendon in the body and facilitates walking, running, and jumping movements.1 Despite its strength, the incidence of Achilles tear has reached approximately 8.3 ruptures per 100,000 people over the last several years due to increased participation in recreational activities.2 Surgical management…
Featured Abstracts Orthopedics Wound Healing

The Use of Bioprinted Skin Grafts for Burn Wound Healing

Kavya Yeruva¬† Introduction: Burns are one of the most common types of trauma, resulting in damage to the epidermis, dermis, and occasionally underlying tissue. The resulting pro-inflammatory response is initiated by vasodilation of nearby blood vessels and diapedesis of various cells into the injured area.1,2,3 Macrophages then release cytokines like…
Wound Healing

The Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles (MSC-EVs) in Promoting M2 Macrophage Polarization in Severe Cutaneous Burn Wounds Following MSC Treatment

Ian T. Bui Introduction. Severe cutaneous burn wound is classified as a third- or higher-degree full thickness burn that involves destruction of epidermis and dermis1. Macrophages influence all steps in wound healing through their phenotypic polarization: pro-inflammatory M1 phenotype and anti-inflammatory M2 phenotype2,3. Traditional treatments such as Early Excision and…
Stem Cells Wound Healing