Mechanisms Regulating Th17 T Cells Implicated in the Pathogenesis of Autoimmune Conditions Like Arthritis

Jacob Moser Introduction. Many chronic inflammatory diseases like asthma, rheumatoid arthritis, and many others owe their pathogenicity to ‘typical’ inflammatory cytokines like TNFa, and can be targeted clinically by widely used drugs like Adalimumab (Humira). But recently discovered types of asthma, rheumatoid arthritis, and others that did not respond adequately…
Featured Abstracts Immunology Inflammation

Deleterious Effects of General Anesthetic Agents on the Developing Brain via Actions on the mTOR Signaling Pathway

Brian Scot Welborn II Introduction.  Neuronal synaptogenesis is the most sensitive neurodevelopment period.  It begins around 20 weeks of gestation and continues throughout adolescence.  Repeated or long-term exposure to general anesthetic agents may have a significant impact on synaptogenesis and neuroapoptosis in the developing brain1,2.  The neurotoxic effects of general…
Neuroscience

The Use of Anesthetic Agents for Non-Anesthetic Purposes: Ketamine as an Alternative for Treatment-Resistant Depression

Devon Weidner Introduction. Treatment Resistant Depression (TRD) affects 1% of individuals in the US and 30% of depressed patients1. Patients with treatment resistant depression are those who have been unsuccessful with treatment from two different classes of antidepressants for a sufficient duration of time and dosage2. Treatment for these patients…
Featured Abstracts Neuroscience

Nanomolecule, Titanium dioxide, Induces Breast Cancer Metastasis in Animal Models by Disrupting Vascular Endothelial Cadherens

Colten Watson Nanomedicine is a relatively new application of nanotechnology. Nanoparticle are used to carrier and deliver a therapeutic payload to cancerous cells in the tissue. A fundamental issue with nanomedicine is that although the benefits have been well documented and studied, several nanoparticles in therapeutic use have been shown…
Cancer