The Mechanism of Zika Virus Infection Including the Role of Nonstructural Proteins in the Pathogenesis of Microcephaly and Guillain-Barre Syndrome

Heather Villarreal Introduction. Zika virus (ZIKV) is a growing epidemic affecting several countries, whose effects include severe neurological damage such as Guillain-Barre syndrome and microcephaly. The virus infects peripheral dendritic tissue and transports axonally to neurons, especially neuroprogenitor cells, where it causes down-regulation of growth and development genes, apoptosis, and…
Microbiology Neuroscience