Month: September 2017

Exercise Induced Changes on miRNA Expression and Its Effect on Cardiovascular Disease

September 21, 2017 Brittney Jackson
Brittney Jackson Introduction: Cardiovascular diseases (CVD) are the leading cause of death in the United States and consume a significant amount of healthcare expenditures8. It is well researched and known that gene expression patterns are substantially altered in cardiac hypertrophy, myocardial infarction (MI), and heart failure5. microRNAs (miRNAs) are short…
Cardiology

The Role of Acetylation of Tau in Alzheimer’s Disease

September 21, 2017 Jason Hutzler
Jason Hutzler  Introduction.  Alzheimer’s Disease (AD) is a progressive, and ultimately fatal neurodegenerative disorder that is currently the sixth leading cause of death in the United States, and the fifth leading cause of death for individuals over the age of 651. AD is characterized by, and can only be definitively…
Neuroscience

The Role of the Gut Microbiome in Mediating Obesity

September 21, 2017 Connie Hsiao
Connie Hsiao  Introduction.  Obesity is a condition characterized by excessive adipose tissue and increases an individual’s risk for health, social and mental issues. Obesity is a major issue in the United States, where more than one- third of Americans are clinically obese (BMI ≥ 30 kg/m2).[1] Environmental and genetic factors…
Microbiology

Orthobiologics and the Role of Osteoinductive Proteins in Bone Repair: With Emphasis on Human Bone Morphogenic Protein (BMPs)

September 21, 2017 Garret Hisle
Garret Hisle  Introduction: The process of bone repair and the healing of bone fractures caused by trauma or disease has a significant clinical relevance due to the limited effectiveness in current treatment options. Among the Osteoinductive growth factors used for bone tissue stimulation, bone morphogenetic proteins (BMPs) are the most…
Orthopedics

The Role of Early Pregnancy’s Downregulation of Hormone Responsive Cells and Wnt Signaling Pathway in Breast Cancer Protection

September 21, 2017 Haley Griffin
Haley Griffin  Introduction: Breast cancer is the predominant cancer and second cause of death due to women. The mammary epithelium undergoes extensive changes throughout a women’s life, and these developmental alterations are associated with progesterone and estrogen. As a result, ER+/PR+ subtype breast cancers are especially linked to reproductive risk…
Cancer Endocrinology

PRIMA1-MET as a potential therapy for colorectal cancer

September 21, 2017 Benjamin Garcia
Benjamin Garcia  Introduction: Colorectal cancer (CRC) is the third most common cancer in men and the second most common cancer in women worldwide1. Colorectal cancer commonly arises from benign neoplasms, called tubular adenomas and serrated polyps, which slowly evolves into CRC over many years2. Over the last three decades, many…
Cancer