GLP-1R Agonists in the Treatment of Diabetes Mellitus: Reducing Serious Comorbidities

W. Marshall Fettig Background: Type 2 Diabetes Mellitus (T2DM) is a major health problem worldwide, characterized by persistent hyperglycemia, and associated with both long and short-term complications. T2DM affects approximately 374 million adults aged 20-79 worldwide,1 and its impact on the US economy was estimated at $327 billion in 2017.2…
Endocrinology Engineering Medicine

Triple Combination Therapy of CDK4/6 Inhibitors, Endocrine Therapy, and mTOR/PI3K Inhibitors to Treat Hormone Receptor-Positive Human Epidermal Growth Factor Receptor-2 Negative Breast Cancer with Acquired Resistance

Rebecca Waugh Background: In America breast cancer is the most frequently diagnosed malignancy in women2,5. Hormone receptor-positive human epidermal growth factor receptor-2 negative (HR+/HER2-) tumors categorize 65-70% of all cases and has one of the lowest survival rates1,2. Recent meta-analysis incorporate modulation CDK 4/6 inhibitors (CDKi) with endocrine therapy as…
Cancer Endocrinology Featured Abstracts

The Potential Use of CDK7 Inhibitors to Treat Metastatic Castration-Resistant Prostate Cancer via Reduction in MED1 Phosphorylation and Androgen Receptor Signaling.

Michael Hembrough Background: Prostate cancer (PC) is the most common malignancy in men. 1,2 PC begins with mutations in prostatic ductal epithelial cells, which produce androgen receptor (AR), a transcriptional regulator for genes controlling cell homeostasis. 1 These mutations increase AR signaling, driving tumorigenesis and metastasis. 2 Eventual progression to…
Cancer Endocrinology Featured Abstracts

In Pancreatic Islets from Type 2 Diabetes Patients, the Dampened Circadian Oscillators Lead to Reduced Insulin and Glucagon Exocytosis

Brock Jones Background: Type 2 Diabetes Mellitus (T2D) is a disease resulting from decreased insulin sensitivity within the body mainly due to lifestyle choices related to diet and exercise.1 T2D seems to mainly stem from lifestyle, with a high caloric and high glycemic diet with insufficient exercise increasing the rate…
Circadian Rhythms Endocrinology Featured Abstracts

Protein C and its Interaction with YB-1 as a Potential Therapeutic in Diabetic Cardiomyopathy Caused by Hyperglycemia Induced Oxidative Stress

Julia Hwang Background: Diabetes mellitus is the fifth most common cause of death in the world.2¬† Type 1 Diabetes is an autoimmune condition where pancreatic beta cells are destroyed, leaving the body unable to produce insulin.1 Diabetics are 2-3 times more likely to develop cardiovascular diseases, and 80% of diabetic…
Endocrinology Featured Abstracts

Targeting the PI3K/AKT/mTOR Pathway to Overcome Resistance to Endocrine Therapy and CDK4/6 Inhibitors in Estrogen Receptor-Positive Metastatic Breast Cancer

Holly Hodge Background: Breast cancer has continued to increase in incidence and now accounts for 31% of all cancer diagnoses1. Breast cancer is classified into subtypes based on the presence of hormone receptors and the human epidermal growth factor receptor 2 protein1. Hormone receptor-positive breast cancer is the most common…
Cancer Endocrinology Featured Abstracts

The Impact of SGLT 2 Inhibitors on Calcium Cycling and Fibrosis in Cardiac Tissues of Patients with Type 2 Diabetes Mellitus and Heart Failure

Brittany Landavazo Background: Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia due to defective insulin secretion by pancreatic beta cells and insulin resistance.1 T2DM patients have a higher risk of mortality with cardiovascular diseases, such as heart failure, being the highest cause of morbidity and mortality.1,2…
Cardiology Endocrinology Featured Abstracts

An Application of Mesenchymal Stem Cell-derived Extracellular Vesicles in the Reduction of Proinflammatory Signaling via Delivery of miRNA-126 in the Progression of Diabetic Retinopathy

Abigail Hawkins ¬†Background: Diabetic retinopathy is the primary ocular complication of uncontrolled diabetes mellitus and a chief cause of visual loss in the elderly.1 Pathogenesis is characterized by pro-inflammatory signaling, via markers such as high mobility group box 1 (HMGB1), and oxidative stress, resulting in breakdown of the blood-retinal barrier…
Endocrinology Featured Abstracts Inflammation

Acetylation and Activation of AR K609 and ACK1 Promote Resistance to Androgen Receptor Antagonists in Castration-Resistant Prostate Cancer

Bryan Kim ¬†Background: Prostate cancer is the leading cancer diagnosis in men and one of the leading causes of cancer-related death in the United States.1 Castration-resistant prostate cancer (CRPC) is the radiographic progression and/or rising prostate-specific antigen (PSA) following androgen deprivation therapy (ADT).2 CRPC patients exhibit resistance to second-generation androgen…
Cancer Endocrinology

Effects of the FKBP5 Gene on Glucocorticoid Receptors in Relation to Major Depressive Disorder

Sandra Kumar Introduction: Major Depressive Disorder (MDD) is a mood disorder involving persistent feelings of anhedonia that affects approximately 350 million people around the world.1 While the etiology of depression can be traced back to the hypersecretion of cortisol and faulty hypothalamic-pituitary-adrenal (HPA) axis, studies look at the role of…
Endocrinology Psychiatry