Category: Reproduction

The Role of Antiphospholipid Antibodies in Miscarriage

July 24, 2023 Varshni Nandakumar
Varshni Nandakumar Background: Miscarriages are defined as the spontaneous loss of a pregnancy before 20 weeks of gestation and affect around 10% of all clinically-recognized pregnancies in the USA1. Moreover, there is a clear link between autoimmune conditions and higher incidences of miscarriage. Patients with autoimmune conditions can develop antiphospholipid…
Engineering Medicine Featured Abstracts Gynecology Reproduction

Cord Blood Lymphatic Endothelial Progenitor Cells Exposed to Preeclampsia in Utero Prime Individuals to Form an Abnormal Lymphatic System After Birth

June 22, 2023 Samantha Pozo Navarro
Samantha Pozo Navarro Background: Preeclampsia is a complex, new-onset hypertensive disorder that affects 3-8% of all pregnancies worldwide.1 In this case, hypertension is defined when the mother’s systolic blood pressure is greater than or equal to 140 mmHg and/or her diastolic blood pressure is greater than or equal to 90…
Development Featured Abstracts Reproduction

HLA-G: Immune Regulation in Pregnancy and a Potential Role in Preeclampsia

June 22, 2023 Phuong-Lan Vo
Phuong-Lan Vo Background: Preeclampsia effects anywhere from 1-10% of pregnant women worldwide and ~4% of pregnancies in the United States.1 Severe preeclampsia is also linked with placental abruption, pre-mature labor, liver failure, intrauterine growth restriction, and maternal death.2 Preeclampsia pathophysiology can be characterized first by impaired invasion of the trophoblast…
Development Reproduction

Inhibition of AT1R-B2R Aggregates Decreases Endothelial Calcium Signaling and Alleviates Preeclampsia

June 12, 2022 Chantal Kinsey
Chantal Kinsey Introduction. Preeclampsia is the leading cause of death of pregnant women and the most common pregnancy complication with gestational hypertension leading to end-organ dysfunction.1,2 The mechanism by which preeclampsia induces organ damage is similar to other hypertensive conditions mediated by the upregulation of renin-angiotensin system (RAS) and downregulation…
Gynecology Inflammation Reproduction

Minimally Invasive Preimplantation Genetic Testing for Aneuploidy in In vitro Fertilization

August 12, 2021 Natalie Miroballi
Natalie Miroballi Introduction. Infertile individuals often seek assisted reproductive technology (ART) to aid in conception, the most common of which is In vitro fertilization (IVF) therapy. The success rate of IVF is highly variable and depend on several clinical factors including the underlying causes of infertility and the woman’s age.…
Featured Abstracts Gynecology Reproduction

Hypoxic Stress Causes an Increase in Microvesicles Leading to Placental Endothelial Dysfunction in Preeclampsia

August 3, 2021 Kelbi Padilla
Kelbi Padilla Introduction: Preeclampsia is a pregnancy-induced disorder defined as new-onset hypertension (>140/90 mmHg) and one of the following after 20 weeks of gestation: proteinuria, most commonly; thrombocytopenia; renal insufficiency; impaired liver function; persistent abdominal pain; or pulmonary edema.1 Preeclampsia affects 5-8% of pregnancies and is a leading cause of…
Reproduction