Category: Reproduction

The Role of sFlt-1–Mediated VEGFA Suppression in Trophoblast Dysfunction and Placental Insufficiency

July 1, 2026 Adya Cherukuri
Adya Cherukuri Background:  Placental insufficiency is a pathological condition in which the placenta fails to provide adequate oxygen and nutrients to support fetal development and is associated with complications such as fetal growth restriction (FGR), preeclampsia, preterm birth, and stillbirth.¹ Proper placental development depends on trophoblast invasion and spiral artery…
Featured Abstracts Reproduction

Maternal Exercise-Induced Cytokine Modulation and Its Potential Role in Preventing Preeclampsia

July 1, 2026 Madison Arthur
Madison Arthur Background: Preeclampsia is a hypertensive disorder of pregnancy characterized by systemic inflammation, endothelial dysfunction, and abnormal placental development that contributes significantly to maternal and fetal morbidity and mortality worldwide.1 Defective placentation occurs when extravillous trophoblasts (EVTs) fail to adequately invade the maternal decidua and remodel spiral arteries into…
Reproduction

Several Genetic Factors and Aaternal Dietary Habits During Pregnancy Contribute to Ventricular Septal Defect (VSD)

July 17, 2025 Jiyeon Cha
Jiyeon Cha Background: Ventricular Septal Defect (VSD), an aberrant development of the ventricular septum that leaves an opening between the ventricles, is the most common congenital heart defect.1 Although most close spontaneously, large defects produce severe morbidity. The pathogenesis of VSD is also multifactorial, involving both genetic and predispositions and…
Cardiology Reproduction

Exploring the Impact of Reactive Oxygen Species in Human Papilloma Virus Infected Sperm: Implications for Sperm Parameters and Infertility

June 12, 2024 Madison K.W. Sobarzo
Madison K.W. Sobarzo Background: Human Papilloma Virus (HPV) is the most common sexually transmitted STI in the world, with an estimated 6.2 million new cases annually.3 HPV is spread through direct skin to skin contact, specifically sexual contact of any sort.2,3 There is currently no cure for HPV, but vaccines…
Featured Abstracts Microbiology Reproduction

The Impact of Selective Serotonin Reuptake Inhibitor Use During Pregnancy on Embryonic Neurodevelopment

May 31, 2024 Daniela Lopez
Daniela Lopez Background: Perinatal depression is a mood disorder that affects about 7-20% of women during pregnancy.1 To be diagnosed, a woman must experience a major depressive episode during pregnancy according to the DSM-5.2 Currently, first line treatment consists of Selective Serotonin Reuptake Inhibitors (SSRI), but other treatment options include…
Featured Abstracts Reproduction

The Mechanistic Role of Transcriptional and Post-Transcriptional Changes on Fetal NR3C1 Gene Programming and the Pathogenesis of Prenatal Anxiety and Stress

May 31, 2024 Jessica Joseph
Jessica Joseph Background: The time of fetal neurodevelopment in utero is highly sensitive, and fetal neuroplasticity-related changes that are mediated through epigenetic related mechanisms have been shown to have lasting effects on brain development.1-7  Elevated levels of maternal stress and anxiety lead to increased levels of glucocorticoids that are transmitted…
Featured Abstracts Reproduction

The Therapeutic Impact of Exercise-Induced Myokine Secretion in Reducing Oxidative Stress (OS) and Minimizing Diagnostic Symptoms of Polycystic Ovarian Syndrome (PCOS)

May 29, 2024 Courtney Coe
Courtney Coe Background: Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders in reproductive-aged women. An imbalance in hypothalamic-pituitary-ovarian axis signaling leads to symptoms such as excess androgens and ovarian dysfunction. Insulin resistance and compensatory hyperinsulinism are major factors affecting those with PCOS.1 Current guidelines for diagnosis…
Endocrinology Featured Abstracts Reproduction

The Role of Antiphospholipid Antibodies in Miscarriage

July 24, 2023 Varshni Nandakumar
Varshni Nandakumar Background: Miscarriages are defined as the spontaneous loss of a pregnancy before 20 weeks of gestation and affect around 10% of all clinically-recognized pregnancies in the USA1. Moreover, there is a clear link between autoimmune conditions and higher incidences of miscarriage. Patients with autoimmune conditions can develop antiphospholipid…
Engineering Medicine Featured Abstracts Gynecology Reproduction