Reproduction – Proceedings of the Texas A&M Medical Student Grand Rounds

Proinflammatory IL-1α Involvement in Premature Ovarian Failure: Impact On Fertility

August 6, 2019 Deanna Vuong

Deanna Vuong Introduction: Premature Ovarian Failure (POF) is a disorder that affects a woman’s ovaries to function correctly prematurely before the age of 40. This disorder affects ~1% of the female population with an unknown etiology due to a multitude of factors. The main clinical manifestation is amenorrhea, accompanied by…

Inflammation Reproduction

The use of SSRIs by pregnant women in a state of depression affect fetal brain circuitry and can result in behavioral changes later in life.

July 12, 2019 Lynette Espino

Lynette Espino Introduction: Serotonin (SERT) plays a role in fetal brain development and mood regulation later in life.1 The use of Selective Serotonin Reuptake Inhibitors (SSRIs) increases anxiety and depression in mice exposed to SSRIs during an early postnatal period.1-4 However, children of women who experienced depression during pregnancy also…

Neuroscience Reproduction

Preferential inhibition of the neonatal μ receptor and CREB-regulated nuclear transcription as a mechanism of treatment of opioid-dependence during pregnancy

July 11, 2019 Keirsyn Criss

Keirsyn Criss Introduction. Exogenous opioids target the μ receptor which is a G-protein coupled receptor, stimulating the production of cAMP. Overuse and opioid addiction has been on the rise in recent years, with the advent of the “opioid crisis”.5-8 Maternal use of opioids during pregnancy has become a recent concern, and…

Reproduction

Obesity in Pregnant Women Leads to Lipotoxicity and Dysfunction in Placentas

July 2, 2019 Kevin Chin

Kevin Chin Introduction: Worldwide, the prevalence of obesity has been steadily increasing over the past few decades. According to the World Health Organization (WHO), obesity worldwide has tripled since 1975. Defined as a Body Mass Index (BMI) of over 30, this condition is a risk factor for many diseases, such as…

Endocrinology Nutrition Reproduction

Alteration and Characterization of Exosomes in Preeclampsia

August 10, 2017 Marisa Pinson

Marisa Pinson Introduction. Preeclampsia (PE) is defined by new onset hypertension and proteinuria by ≥20 weeks of gestation.1-4 PE occurs in 2-5% of pregnancies and is the leading cause of maternal and fetal morbidity and mortality globally.1 Currently, the only treatment for PE is delivery of the placenta. The mechanisms behind the…

Featured Abstracts Reproduction

The Role of Extracellular Vesicles in the Pathogenesis of Preeclampsia

August 2, 2017 Jennifer Rogers

Jennifer Rogers Introduction. Preeclampsia (PE), a hypercoagulable pregnancy disorder that involves multiple organs, is a leading cause of maternal and fetal mortality.1,2 PE is characterized by hypertension presenting after 20 weeks gestation, along with other symptoms, including proteinuria, thrombocytopenia, edema, and cerebral or visual changes.1,2 If PE remains untreated, it…

Featured Abstracts Reproduction

Inflammation and stress in preeclampsia due to microparticles of the endothelium and the trophoblast

July 31, 2017 Laura Chahin

Laura Chahin Introduction – The maternal condition preeclampsia currently has an incidence of 3-5%1 and affects both neonates and mothers globally as the most common cause of mortality2. Preeclampsia can be identified beginning at 20 weeks gestation by hypertension, protein present in urine, and, most concerning, damage to additional organs1.…

Featured Abstracts Reproduction