Alteration and Characterization of Exosomes in Preeclampsia

Marisa Pinson  Introduction.  Preeclampsia (PE) is defined by new onset hypertension and proteinuria by ≥20 weeks of gestation.1-4 PE occurs in 2-5% of pregnancies and is the leading cause of maternal and fetal morbidity and mortality globally.1 Currently, the only treatment for PE is delivery of the placenta. The mechanisms behind the development of PE are still […]

The Role of Extracellular Vesicles in the Pathogenesis of Preeclampsia

Jennifer Rogers Introduction. Preeclampsia (PE), a hypercoagulable pregnancy disorder that involves multiple organs, is a leading cause of maternal and fetal mortality.1,2 PE is characterized by hypertension presenting after 20 weeks gestation, along with other symptoms, including proteinuria, thrombocytopenia, edema, and cerebral or visual changes.1,2 If PE remains untreated, it may progress to eclampsia, which […]

Inflammation and stress in preeclampsia due to microparticles of the endothelium and the trophoblast

Laura Chahin Introduction – The maternal condition preeclampsia currently has an incidence of 3-5%1 and affects both neonates and mothers globally as the most common cause of mortality2. Preeclampsia can be identified beginning at 20 weeks gestation by hypertension, protein present in urine, and, most concerning, damage to additional organs1. Inhibition of spiral artery reformation […]