Dysfunction of the Hypothalamic-Pituitary Axis in Prader-Willi Syndrome: An emerging understanding of pertinent genetic and molecular players

Brooke Evans Introduction. Prader-Willi Syndrome (PWS) is the leading syndromic cause of obesity.1  The syndrome is caused by non-expression of paternally imprinted genes on chromosome 15 (15q11.2-13) and was the first human disorder linked to genomic imprinting.2 The minimal critical deletion chromosomal domain for PWS contains a non-coding RNA SNORD116…
Development

Alteration and Characterization of Exosomes in Preeclampsia

Marisa Pinson  Introduction.  Preeclampsia (PE) is defined by new onset hypertension and proteinuria by ≥20 weeks of gestation.1-4 PE occurs in 2-5% of pregnancies and is the leading cause of maternal and fetal morbidity and mortality globally[1]. Currently, the only treatment for PE is delivery of the placenta. The mechanisms behind…
Development