Sara Zoghi Background: Breast cancer is a heterogeneous disease concerning the transformation of mammary ductal and luminal epithelial cells.1 It was the most diagnosed cancer of 2020, with ER+ cancers accounting for over 70% of the diagnoses.1  Worldwide, it accounts for 15.5% of all female deaths, making it the most…
Cancer

Possible Non-Anesthetic Use of Propofol in Post-traumatic Stress Disorder

Kent Yamamoto Background: Post-traumatic stress disorder (PTSD) is a severe psychiatric disorder that develops in the months and years following exposure to severe trauma.1 Current treatment for PTSD includes pharmacotherapies with serotonin reuptake inhibitors and psychotherapies in the form of exposure-based treatment.1 Serotonergic, dopaminergic, and noradrenergic antidepressants and/or anxiolytic medications…
Featured Abstracts Neuroscience

Genetic Mechanisms of Colorectal Cancer and Metastasis, Characterization of SMOC gene and Implications of its Role in BMP Signaling and the Progression of Colorectal Traditional Serrated Adenomas

Joy Wang Background: Colorectal cancer is currently the third most common cancer type, while also representing the second most lethal. Sequential accumulation of genetic and epigenetic abnormalities are involved in the transformation of healthy colorectal epithelium toward neoplasms and metastasis1. Sporadic onset of CRC comprises the majority of cases (70%),…
Cancer

DC3 Cells Infiltration in the Tumor Microenvironment is Associated with Immune Response of Leptomeningeal and Brain Metastatic Melanoma

William Wakeland Background: Metastatic melanoma presents a formidable challenge due to its aggressive nature and dissemination. 325,000 new melanoma cases were diagnosed in 2020. An estimation of 510,000 new cases per year is predicted by 20401. Despite advancements in treatment modalities and the  high incidence of the disease, metastatic melanoma…
Cancer Featured Abstracts Immunology

Role of Rac1 in Mitochondrial Damage Exacerbating Diabetic Retinopathy

Danny Varghese Background:  Diabetic retinopathy (DR) is a leading cause of vision impairment among adults globally, with prevalence rates expected to rise alongside increasing diabetes incidence.1 This condition results from prolonged hyperglycemia and dyslipidemia, leading to oxidative stress and mitochondrial damage within the retinal microvascular endothelium.1,2,3 Vision loss caused by…
Diabetes Featured Abstracts