The Role of Circadian Clock Proteins in the Pathogenesis of Breast Cancer

Faraz Damghani Introduction. The suprachiasmatic nucleus controls the circadian rhythm of the body and disruptions of this rhythm has been linked to breast cancers. Breast cancer accounts for 25% of cancers which affect women, making it the most common malignancy in females worldwide. Based on different phenotypes, breast cancer can be divided into two main […]

The Mechanism of Zika Virus Infection Including the Role of Nonstructural Proteins in the Pathogenesis of Microcephaly and Guillain-Barre Syndrome

Heather Villarreal Introduction. Zika virus (ZIKV) is a growing epidemic affecting several countries, whose effects include severe neurological damage such as Guillain-Barre syndrome and microcephaly. The virus infects peripheral dendritic tissue and transports axonally to neurons, especially neuroprogenitor cells, where it causes down-regulation of growth and development genes, apoptosis, and overall atrophy of developing neural […]

Restoring Cognition in Alzheimer’s Disease with hiPSC-derived Cholinergic Neuron Transplantation

Jonathon Cummock  Introduction: Alzheimer’s disease (AD) is a progressive, debilitating neuropsychiatric disorder characterized by multifaceted decline in cognitive and behavioral functions1, 11. Key neuronal pathology includes amyloid-beta plaques and/or neurofibrillary tangles1, 11. A well-known feature of AD is the marked reduction and death of cholinergic neurons in the basal forebrain with subsequent reduction in acetylcholine […]

The gut microbiome mediates obesity through complex interactions with short chain fatty acids (SCFAs)

Danfeng Lisa Wang  Introduction. Obesity is a major risk factor contributing to the worldwide burden of disease1. Recent studies show gut microbial composition differs between lean and obese phenotypes in mice and humans. Lean phenotypes tend to have a greater proportion of Bacteroidetes bacteria, while obese phenotypes tend to have a greater proportion of Firmicutes […]

Histone Modification in Alcoholism: Peripheral to Central Processes

Esra Gumuser Introduction. Alcohol Use Disorder affects the United States both economically, with excessive binge drinking costing the U.S. $249 billion in 2010 alone1, and in mortality, being responsible for over 30,000 deaths in the 20142.  Long-term alcohol use is known to affect nearly every organ system primarily through epigenetic remodeling entailing histone modifications that […]

Restoring Cognition in Alzheimer’s Disease with hiPSC-derived Cholinergic Neuron Transplantation

Jonathon Cummock  Introduction: Alzheimer’s disease (AD) is a progressive, debilitating neuropsychiatric disorder characterized by multifaceted decline in cognitive and behavioral functions1, 11. Key neuronal pathology includes amyloid-beta plaques and/or neurofibrillary tangles1, 11. A well-known feature of AD is the marked reduction and death of cholinergic neurons in the basal forebrain with subsequent reduction in acetylcholine […]

Bacteriophage as an Antimicrobial against Pseudomonas aeruginosa in Burn Patients

Kendall Turner Introduction Pseudomonas aeruginosa is a gram negative bacterium and opportunistic human pathogen with intrinsic antibiotic resistance capabilities and adaptive mechanisms.1 The organism has the third highest incident rate of nosocomial infections in burn patients, composing 9.00 to 18.30% of burn infections.2 Furthermore, P. aeruginosa is a major cause of skin graft loss in […]

Utilizing Regulatory T Cells in the Treatment and Prevention of Diabetes Mellitus Type I

Alexander Sanders  Introduction. Type I Diabetes Mellitus is a multifactorial autoimmune disease that targets and destroys pancreatic islet cells which produce insulin. It is most often diagnoses during childhood and affects millions of people around the world. While much is known about the disease and how to treat it, significant research is still needed on […]