The Role of Bumetanide and Its Derivatives in Potentiating GABAergic Medications as a Treatment for Neonatal Seizures

Ramya Varadarajan Introduction. Neonatal seizures are commonly attributed to irregular accumulations of high levels of Cl- in neonatal neurons.1,4,6,7 This leads to difficulty in administering phenobarbital (a GABAergic medication) as a treatment for seizures, as opening of GABA channels leads to neuronal depolarization due to Cl- efflux rather than the expected…
Neuroscience

Restoring the Endometrial Microbiota to Overcome the Consequence of Infertility in Women with a History of Gynecologic Infection

Medha Narwankar Introduction. Pelvic inflammatory disease (PID) is a broad spectrum of reproductive tract infections that can cause inflammation and damage to fallopian tubes1,2. The endometrial microbiome creates a biofilm and dynamic interface that supports interaction between gametes, the embryo, and maternal tissue3. Statistics have shown that 2.5 million reproductive-aged…
Gynecology Microbiology

The Role and Consequences of Methadone, in the Face of the Ongoing Opioid Crisis, on the hERG Channel in Prolonged QT Interval

Austin Hughes Introduction. Prolonged QT interval results from genetic or acquired causes, characterized by prolongation of the QT interval, the period from onset of cardiac ventricular depolarization to the end of ventricular repolarization.1  Drug-induced QT prolongation is common among recovering opioid dependents, particularly in those who are prescribed racemic methadone, the…
Cardiology Psychiatry

The Role of Organ-on-a-Chip Devices in Alzheimer’s Disease Drug Discovery and Disease Modeling

Solyman Hatami Introduction: Alzheimer’s disease (AD), the leading cause of dementia worldwide, is an irreversible neurodegenerative disease characterized by memory loss and executive dysfunction.1  It is characterized by intracellular neurofibrillary tangles and extracellular amyloid beta (Aβ) plaques through improper cleavage of amyloid precursor protein by β-secretases. Aβ aggregation is known…
Engineering Neuroscience

The Role of Polycystin 1 and Polycystin 2 (PC1/PC2) in Calcium Intake and Pathogenesis of Autosomal Dominant Kidney Disease

Tarek Dawamne Introduction. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common potentially lethal single gene disorder. ADPKD is often associated with renal cysts that cause increased kidney malfunction such as hematuria, flank pain, kidney stones, carcinoma, in addition to other cardiovascular abnormalities1.  Methods. Many sources were reviewed to…
Featured Abstracts Renal Genitourinary