Rapid Healing: Accelerating Chronic Diabetic Wound Repair Via Setdb2 and NF-κB Modulation of Macrophage Polarization During Inflammation

Ahad Azimuddin  Introduction. Chronic diabetic wounds (CDWs) present a significant physical and financial burden on our society. More than 6.5 million Americans suffer from non-healing wounds, costing $35.3 billion to Medicare.1 Pathologic wound repair disrupts any of the four stages of physiologic wound repair: hemostasis, inflammation, proliferation/repair, and remodeling.1,2 In the…
Immunology Inflammation

The Role of Gut Microbiota Metabolites in Modulating the Inflammatory Effects Leading to Atopic Dermatitis

Hope Allen Introduction. Atopic Dermatitis (AD) is a chronic inflammatory skin disease with causal links ranging from a dysregulated immune response, genetic factors, and the environment.1 AD is diagnosed by the presence of itching, epidermal barrier dysfunction, lesions with increased T-helper 2 (Th2) cells, mast cells, eosinophils, and increased IgE…
Immunology Inflammation

Mechanisms Regulating Th17 T Cells Implicated in the Pathogenesis of Autoimmune Conditions Like Arthritis

Jacob Moser Introduction. Many chronic inflammatory diseases like asthma, rheumatoid arthritis, and many others owe their pathogenicity to ‘typical’ inflammatory cytokines like TNFa, and can be targeted clinically by widely used drugs like Adalimumab (Humira). But recently discovered types of asthma, rheumatoid arthritis, and others that did not respond adequately…
Featured Abstracts Immunology Inflammation

Pathogenesis of how IL-17A produced by CD4+ T helper 17 cells result in renal and vascular dysfunction and augment angiotensin II induced hypertension

Adiba Hasnat Introduction.  Angiotensin II hypertension is strongly linked to the immune system since many of the detrimental effects are caused by the inflammatory response mediated by immune cells such as Th17 cells7. Th17 have been shown to augment and not just be a secondary response to hypertension by promoting…
Cardiology Immunology

MSC-Induced T-reg proliferation as a potential therapy for Multiple Sclerosis

Caleb Ellis Introduction. Multiple Sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system that leads to progressively worsening and permanent neurological defects.1 MS is characterized by the activation of aberrant T-cells which then recognize and destroy myelinated neurons and oligodendrocytes, causing a massive inflammatory event and permanent…
Featured Abstracts Immunology Neuroscience