Katie Litman Introduction. Food allergies in the US increased dramatically over the past decade, affecting 8% of Americans. Peanut allergies are a lifelong and life-threatening problem.1 They progress quickly (<2hrs) and have become the leading cause of anaphylaxis/death related to […]
Jacob Moser Introduction. Many chronic inflammatory diseases like asthma, rheumatoid arthritis, and many others owe their pathogenicity to ‘typical’ inflammatory cytokines like TNFa, and can be targeted clinically by widely used drugs like Adalimumab (Humira). But recently discovered types of […]
Alyssa Woltemath Introduction: Neonatal hypoxic-ischemic brain injury occurs in 1 to 6 births for every 1,000 live term births4. Researchers worked to understand the pathogenesis mechanism of HIE by upregulation and downregulation of IL-1b, IL-6 and IL-15. Interleukin-1b is produced […]
Kevin Windecker Bicuspid aortic valve (BAV) is one of the most common types of congenital heart malformations1,2 and occurs in 0.5–2% of the population worldwide3. In this condition, the aortic valve, which typically is comprised of three leaflets, consists of […]
Katie Litman Introduction. Food allergies in the US increased dramatically over the past decade, affecting 8% of Americans. Peanut allergies are a lifelong and life-threatening problem.1 They progress quickly (<2hrs) and have become the leading cause of anaphylaxis/death related to […]
Rayomand Katrak Introduction. Ulcerative colitis is a chronic inflammatory disease that presents with mucosal inflammation starting in the rectum and extending proximally in the colon9. Ulcerative colitis is believed to be caused by dysbiosis between intestinal microbiota and mucosal immunity, […]
Adiba Hasnat Introduction. Angiotensin II hypertension is strongly linked to the immune system since many of the detrimental effects are caused by the inflammatory response mediated by immune cells such as Th17 cells7. Th17 have been shown to augment and […]
Caleb Ellis Introduction. Multiple Sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system that leads to progressively worsening and permanent neurological defects.1 MS is characterized by the activation of aberrant T-cells which then recognize and destroy myelinated […]
Morgan Cattoor Introduction. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease driven by aberrant responses in both innate and adaptive immunity.1 Standard treatment consists of immunosuppressive agents such as corticosteroids, azathioprine, and methotrexate.2 When these therapies fail, mesenchymal stem […]
Napoleon Busbuso Introduction. Cardiovascular disease originating from atherosclerosis is the leading cause of death worldwide1. In the setting of dyslipidemia, LDL accumulates within the intima of arteries, and subsequent oxidation of LDL by free radicals incites a persistent inflammatory reaction […]