The Role of Allogeneic Stem Cell Therapy in Treatment of Refractory Rheumatoid Arthritis by Immunomodulating the Treg and Th17 Balance
Dariusz Mrugala Introduction. Rheumatoid Arthritis (RA) is a chronic progressive autoimmune disease which primarily affects the distal articular joints, and especially the hands.1 The interaction of heritable risk factors like HLA-DR04, and environmental risk factors such as smoking, promote a loss of immune tolerance for self-antigens which leads to immune…