Category: Immunology

Mechanistic Determinants of CTLA-4 Blockade-Mediated Antitumor Immunity in Melanoma: Contributions of Complementary Checkpoint Signaling, Fc Effector Function, and Tumor Metabolic Context

July 3, 2026 Sindhoora Ponnam
Sindhoora Ponnam Background: Cancer is a leading cause of mortality globally, killing approximately 10 million people in 2020.6 Immunotherapy is an emerging cancer therapeutic defined as the treatment of disease by activating or suppressing components of the patient’s immune system rather than directly targeting tumor cells, especially in terms of…
Cancer Immunology

Engineering Dual-Affinity Molecules to Redirect Immune Effector Cells for the Elimination of Latent HIV-1 Reservoirs

July 2, 2026 Neha B Mullassery
Neha B Mullassery Background: The latent HIV-1 reservoir—a pool of resting memory CD4+ T cells harboring integrated, transcriptionally silent proviral DNA—remains the primary barrier to a functional cure.6,7 While these cells remain “invisible” to the host immune system under suppressive antiretroviral therapy (ART), they can be reactivated by latency-reversing agents.…
Immunology Microbiology

Engineered T Regulatory Cells as Antigen-Specific Immunotherapy for Multiple Sclerosis: From TCR Modification to CAR Treg Optimization

July 2, 2026 Rosemarie Faustina Le
Rosemarie Faustina Le Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by neuroinflammation, demyelination, and neurodegeneration which collectively lead to significant physical and cognitive disabilities.1-3 Currently, 2.9 million people worldwide live with MS with the highest prevalence found in Europe and the…
Immunology Neuroscience

Impact of Anti-Fentanyl Vaccination on the Pharmacokinetics and Analgesic Efficacy of Fentanyl

July 1, 2026 Fatimah Khan
Fatimah Khan Background:  The escalating opioid crisis has led to significant public health concerns, with fentanyl playing a central role due to its high potency and prevalence in illicit drug markets. 1,2 Fentanyl’s exceptional lipophilicity enables it to cross the blood-brain barrier and activate µ-opioid receptors, leading to powerful euphoria,…
Featured Abstracts Immunology Pain Management

The Role of Antigen Presenting Myeloid Cell in Mediating Radioimmunotherapy Efficacy in Triple Negative Breast Cancer

July 1, 2026 Faith Haugen
Faith Haugen Background: Triple negative breast cancer (TNBC) is an cancer subtype defined by the absence of estrogen, progesterone, and human epidermal growth factor 2 (HER2) receptors.6 The lack of these receptors leaves proliferative signaling pathways unchecked and significantly limits the availability of targeted therapies.6 Current treatment approaches rely predominantly…
Cancer Immunology

Gut IgA Dysregulation and B-Cell Dysfunction in Multiple Sclerosis

July 1, 2026 Ava Denton
Ava Denton  Background: Multiple sclerosis is a chronic immune-mediated demyelinating disease of the central nervous system affecting roughly 2.3 million people worldwide.2 Myelin loss disrupts nerve conduction and contributes to progressive neurologic dysfunction.2  Although MS symptoms arise in the CNS, immune dysregulation outside the CNS may also influence disease activity,…
Featured Abstracts Immunology

Anti-CD19 CAR T Cell Therapy in Systemic Lupus Erythematosus

July 1, 2026 Ayleen Chen
Ayleen Chen Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by dysregulated immune responses and the production of autoantibodies that target self-antigens, leading to inflammation that affects multiple organs. 1 Traditional treatment strategies for SLE include non-specific immunosuppressive and anti-inflammatory agents such as glucocorticoids, immunosuppressants like mycophenolate mofetil,…
Featured Abstracts Immunology Inflammation

M2 Macrophage Driven CXCL1/CXCR2–NF-κB Signaling in Endometrial Cancer: Mechanisms and Therapeutic Potential

July 1, 2026 Oluwatoyin Banjo
Oluwatoyin Banjo Background: Endometrial cancer (EC) is the most common gynecologic malignancy in the United States, and its incidence continues to rise due to increasing rates of obesity and metabolic dysfunction.1, 2 Type I EC, the predominant subtype, is associated with prolonged estrogen exposure and dysregulated signaling pathways, which promote…
Cancer Immunology